Complex permittivity measurements of lunar samples at microwave and millimeter wavelengths

The relative dielectric constant and loss tangent of lunar sample 14163,164 (fine dust) were determined as a function of density at 9.375, 24, 35, and 60 GHz. In addition, such measurements have also been performed on lunar sample 14310,74 (solid rock) at 9.375 GHz. The loss tangent was found to be frequency independent at these test frequencies and had a value of 0.015 for the lunar dust sample

Conceptual design of an on-board optical processor with components

The specification of components for a spacecraft on-board optical processor was investigated. A space oriented application of optical data processing and the investigation of certain aspects of optical correlators were examined. The investigation confirmed that real-time optical processing has made significant advances over the past few years, but that there are still critical components which will require further development for use in an on-board optical processor. The devices evaluated were the coherent light valve, the readout optical modulator, the liquid crystal modulator, and the image forming light modulator

A study to analyze six band multispectral images and fabricate a Fourier transform detector

An automatic Fourier transform diffraction pattern sampling system, used to investigate techniques for forestry classification of six band multispectral aerial photography is presented. Photographs and diagrams of the design, development and fabrication of a hybrid optical-digital Fourier transform detector are shown. The detector was designed around a concentric ring fiber optic array. This array was formed from many optical fibers which were sorted into concentric rings about a single fiber. All the fibers in each ring were collected into a bundle and terminated into a single photodetector. An optical/digital interface unit consisting of a high level multiplexer, and an analog-to-digital amplifier was also constructed and is described

Sense of Community in Graduate Online Education: Contribution of Learner to Learner Interaction

Distance learning technologies offer a multitude of ways to build interaction into online courses to support learning. Based on social constructivism theory, this study explored which types of interaction are most predictive of students’ sense of community in online graduate courses at a regional comprehensive university. Surveys were used to measure sense of community and the frequency and importance of nine learner–learner interactions. Interactions that were most predictive of sense of community were introductions, collaborative group projects, sharing personal experiences, entire class discussions, and exchanging resources. The interaction that offered the highest payoff to instructors was exchanging resources. The article discusses implications for online course design

Conductivity of dielectric and thermal atom-wall interaction

We compare the experimental data of the first measurement of a temperature dependence of the Casimir-Polder force by Obrecht et al. [Phys. Rev. Lett. {\bf 98}, 063201 (2007)] with the theory taking into account small, but physically real, static conductivity of the dielectric substrate. The theory is found to be inconsistent with the data. The conclusion is drawn that the conductivity of dielectric materials should not be included in the model of the dielectric response in the Lifshitz theory. This conclusion obtained from the long separation measurement is consistent with related but different results obtained for semiconductors and metals at short separations.Comment: 4 pages, 2 figures; page size is correcte

Skeletal Recovery Following Long-Duration Spaceflight Missions as Determined by Preflight and Postflight DXA Scans of 45 Crew Members

Introduction: The loss of bone mineral in astronauts during spaceflight has been investigated throughout the more than 40 years of bone research in space. Consequently, it is a medical requirement at NASA that changes in bone mass be monitored in crew members by measurements of bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA). This report is the first to evaluate medical data to address the recovery of bone mineral that is lost during spaceflight. Methods: DXA scans are performed before and after flight in astronauts who serve on long-duration missions (4-6 months) to ensure that medical standards for flight certification are met, to evaluate the effects of spaceflight and to monitor the restoration to preflight BMD status after return to Earth. Through cooperative agreements with the Russian Space Agency, the Bone and Mineral Lab at NASA Johnson Space Center (Houston, TX), also had access to BMD data from cosmonauts who had flown on long-duration missions yielding data from a total of 45 individual crew members. Changes in BMD (between 56 different sets of pre- and postflight measurements) were plotted as a function of time (days after landing); plotted data were fitted to an exponential mathematical model that determined i) BMD change at day 0 after landing and ii) the number of days after which 50% of the lost bone was recovered ("Recovery Half-Life"). These fits were performed for BMD of the lumbar spine, trochanter, pelvis, femoral neck and calcaneus. Results: In sum, averaged losses of bone mineral after spaceflight ranged between 2-9% for sites in the axial and appendicular skeleton. The fitted postflight BMD values predicted a 50% recovery of bone loss for all sites within 9 months

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ signalling is therefore strictly regulated to ensure appropriate context-dependent physiological responses. In an attempt to identify novel regulatory components of the TGFβ signalling pathway, we performed a pharmacological screen by using a cell line engineered to report the endogenous transcription of the TGFβ-responsive target gene PAI-1. The screen revealed that small molecule inhibitors of salt-inducible kinases (SIKs) attenuate TGFβ-mediated transcription of PAI-1 without affecting receptor-mediated SMAD phosphorylation, SMAD complex formation or nuclear translocation. We provide evidence that genetic inactivation of SIK isoforms also attenuates TGFβ-dependent transcriptional responses. Pharmacological inhibition of SIKs by using multiple small-molecule inhibitors potentiated apoptotic cell death induced by TGFβ stimulation. Our data therefore provide evidence for a novel function of SIKs in modulating TGFβ-mediated transcriptional and cellular responses.</p

Recovery of Spaceflight-induced Bone Loss: Bone Mineral Density after Long-Duration Missions as Fitted with an Exponential Function

The loss of bone mineral in NASA astronauts during spaceflight has been investigated throughout the more than 40 years of space travel. Consequently, it is a medical requirement at NASA Johnson Space Center (JSC) that changes in bone mass be monitored in crew members by measuring bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA) before and after flight on astronauts who serve on long-duration missions (4-6 months). We evaluated this repository of medical data to track whether there is recovery of bone mineral that was lost during spaceflight. Our analysis was supplemented by BMD data from cosmonauts ( by convention, a space traveler formally employed by the Russia Aviation and Space Agency or by the previous Soviet Union) who had also flown on long-duration missions. Data from a total of 45 individual crew members -- a small number of whom flew on more than one mission -- were used in this analysis. Changes in BMD (between 56 different sets of pre- and postflight measurements) were plotted as a function of time (days after landing). Plotted BMD changes were fitted to an exponential mathematical function that estimated: i) BMD change on landing day (day 0) and ii) the number of days after landing when 50% of the lost bone would be recovered ("50% recovery time") in the lumbar spine, trochanter, pelvis, femoral neck and calcaneus. In sum, averaged losses of bone mineral after long-duration spaceflight ranged between 2-9% across all sites with our recovery model predicting a 50% restoration of bone loss for all sites to be within 9 months

Space Deterrence: The Delicate Balance of Risk

The United States has created a military structure that is heavily satellite-dependent, without making corresponding improvements in the survivability of its space systems. The result is a classic opportunity for asymmetric, preemptive attack. The central question of this study is how to structure a strategy of deterrence to persuade potentially hostile actors that the costs of attack will nevertheless outweigh the benefits

Meta-analysis of genome-wide association from genomic prediction models

Genome-wide association (GWA) studies based on GBLUP models are a common practice in animal breeding. However, effect sizes of GWA tests are small, requiring larger sample sizes to enhance power of detection of rare variants. Because of difficulties in increasing sample size in animal populations, one alternative is to implement a meta-analysis (MA), combining information and results from independent GWA studies. Although this methodology has been used widely in human genetics, implementation in animal breeding has been limited. Thus, we present methods to implement a MA of GWA, describing the proper approach to compute weights derived from multiple genomic evaluations based on animal-centric GBLUP models. Application to real datasets shows that MA increases power of detection of associations in comparison with population-level GWA, allowing for population structure and heterogeneity of variance components across populations to be accounted for. Another advantage of MA is that it does not require access to genotype data that is required for a joint analysis. Scripts related to the implementation of this approach, which consider the strength of association as well as the sign, are distributed and thus account for heterogeneity in association phase between QTL and SNPs. Thus, MA of GWA is an attractive alternative to summarizing results from multiple genomic studies, avoiding restrictions with genotype data sharing, definition of fixed effects and different scales of measurement of evaluated traits.Fil: Bernal Rubio, Yeni Liliana. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; Argentina. Michigan State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gualdron Duarte, Jose Luis. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bates, R. O.. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; ArgentinaFil: Ernst, C. W.. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; ArgentinaFil: Nonneman, D.. United States Department of Agriculture. Agricultural Research Service; Estados UnidosFil: Rohrer, G. A.. United States Department of Agriculture. Agricultural Research Service; Estados UnidosFil: King, A.. United States Department of Agriculture. Agricultural Research Service; Estados UnidosFil: Shackelford, S. D.. United States Department of Agriculture. Agricultural Research Service; Estados UnidosFil: Wheeler, T. L.. United States Department of Agriculture. Agricultural Research Service; Estados UnidosFil: Cantet, Rodolfo Juan Carlos. Michigan State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Steibel, J. P.. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; Argentina. Michigan State University; Estados Unido