Psychological Distress and Well-Being among Students of Health Disciplines: The Importance of Academic Satisfaction

Background: Research on the mental health of students in health disciplines mainly focuses on psychological distress and nursing and medical students. This study aimed to investigate the psychological well-being and distress and related factors among undergraduate students training in eight different health-related tracks in Geneva, Switzerland. Methods: This cross-sectional study used established self-filled scales for anxiety, depression, stress, psychological well-being, and study satisfaction. Descriptive statistics and hierarchical regression analyses were applied. Results: In October 2019, out of 2835 invited students, 915 (32%) completed the survey. Lower academic satisfaction scores were strongly associated with depression (β = −0.26, p < 0.001), anxiety (β = −0.27, p < 0.001), and stress (β = −0.70, p < 0.001), while higher scores were associated with psychological well-being (β = 0.70, p < 0.001). Being female was strongly associated with anxiety and stress but not with depression or psychological well-being. Increased age was associated with enhanced psychological well-being. The nature of the academic training had a lesser impact on mental health and the academic year had none. Conclusion: Academic satisfaction strongly predicts depression, anxiety, stress, and psychological well-being. Training institutions should address the underlying factors that can improve students’ satisfaction with their studies while ensuring that they have access to psychosocial services that help them cope with mental distress and enhance their psychological well-bein

Amount of Antiprotons in Cosmic Rays due to Halo Neutralino Annihilation

We evaluate the antiproton--to--proton flux ratio which can be generated by neutralino--neutralino annihilation in the galactic halo, considering the most general compositions for the relic neutralinos and modelling the neutralino local density according to its relic abundance. We find that in the case of mixed neutralino compositions this $\bar p/p$ ratio is higher than for pure higgsinos or gauginos. It is shown how the expected improvements in sensitivity for the new measurements of the $\bar p/p$ may provide very useful information, complementary to the one obtainable with other experimental means.Comment: 13 pages in Plain TeX, 7 figures included in a separate uuencoded tarred-compressed Postscript file; To appear in Astroparticle Physics; Report number: DFTT 35/9

Kinetic decoupling of neutralino dark matter

After neutralinos cease annihilating in the early Universe, they may still scatter elastically from other particles in the primordial plasma. At some point in time, however, they will eventually stop scattering. We calculate the cross sections for neutralino elastic scattering from standard-model particles to determine the time at which this kinetic decoupling occurs. We show that kinetic decoupling occurs above a temperature $T\sim$ MeV. Thereafter, neutralinos act as collisionless cold dark matter.Comment: Replaced with revised version, new references adde

Straightforward quantification of endogenous steroids with liquid chromatography-tandem mass spectrometry: Comparing calibration approaches.

Different calibration strategies are used in liquid chromatography hyphenated to mass spectrometry (LC-MS) bioanalysis. Currently, the surrogate matrix and surrogate analyte represent the most widely used approaches to compensate for the lack of analyte-free matrices in endogenous compounds quantification. In this context, there is a growing interest in rationalizing and simplifying quantitative analysis using a one-point concentration level of stable isotope-labeled (SIL) standards as surrogate calibrants. Accordingly, an internal calibration (IC) can be applied when the instrument response is translated into analyte concentration via the analyte-to-SIL ratio performed directly in the study sample. Since SILs are generally used as internal standards to normalize variability between authentic study sample matrix and surrogate matrix used for the calibration, IC can be calculated even if the calibration protocol was achieved for an external calibration (EC). In this study, a complete dataset of a published and fully validated method to quantify an extended steroid profile in serum was recomputed by adapting the role of SIL internal standards as surrogate calibrants. Using the validation samples, the quantitative performances for IC were comparable with the original method, showing acceptable trueness (79%-115%) and precision (0.8%-11.8%) for the 21 detected steroids. The IC methodology was then applied to human serum samples (n = 51) from healthy women and women diagnosed with mild hyperandrogenism, showing high agreement (R &lt;sup&gt;2&lt;/sup&gt; &gt; 0.98) with the concentrations obtained using the conventional quantification based on EC. For IC, Passing-Bablok regression showed proportional biases between -15.0% and 11.3% for all quantified steroids, with an average difference of -5.8% compared to EC. These results highlight the reliability and the advantages of implementing IC in clinical laboratories routine to simplify quantification in LC-MS bioanalysis, especially when a large panel of analytes is monitored

Enhanced roughness of lipid membranes caused by external electric fields

The behavior of lipid membranes in the presence of an external electric field is studied and used to examine the influence of such fields on membrane parameters such as roughness and show that for a micro sized membrane, roughness grows as the field increases. The dependence of bending rigidity on the electric field is also studied and an estimation of thickness of the accumulated charges around lipid membranes in a free-salt solution is presented.Comment: 9 pages, 6 figures, to appear in Computational Materials Scienc

Positrons from particle dark-matter annihilation in the Galactic halo: propagation Green's functions

We have made a calculation of the propagation of positrons from dark-matter particle annihilation in the Galactic halo in different models of the dark matter halo distribution using our 3D code, and present fits to our numerical propagation Green's functions. We show that the Green's functions are not very sensitive to the dark matter distribution for the same local dark matter energy density. We compare our predictions with computed cosmic ray positron spectra (``background'') for the ``conventional'' CR nucleon spectrum which matches the local measurements, and a modified spectrum which respects the limits imposed by measurements of diffuse Galactic gamma-rays, antiprotons, and positrons. We conclude that significant detection of a dark matter signal requires favourable conditions and precise measurements unless the dark matter is clumpy which would produce a stronger signal. Although our conclusion qualitatively agrees with that of previous authors, it is based on a more realistic model of particle propagation and thus reduces the scope for future speculations. Reliable background evaluation requires new accurate positron measurements and further developments in modelling production and propagation of cosmic ray species in the Galaxy.Comment: 8 pages, 6 ps-figures, 3 tables, uses revtex. Accepted for publication in Physical Review D. More details can be found at http://www.gamma.mpe-garching.mpg.de/~aws/aws.htm

Possible large phase in psi(2S) -> 1-0- Decays

The strong and the electromagnetic amplitudes are analyzed on the basis of the measurements of J/psi, psi(2S) -> 1-0- in e+e- experiments. The currently available experimental information is revised with inclusion of the contribution from e+e- -> gamma * -> 1-0- . The study shows that a large phase around minus 90 degree between the strong and the electromagnetic amplitudes could not be ruled out by the experimental data for psi(2S).Comment: 4 page

Prevalence and correlates of DSM-5 major depressive and related disorders in the community.

Although the DSM-5 has suggested the two new categories of Persistent Depressive Disorders (PDD) and Other Specified Depressive Disorders (OSDD), no study so far has applied the DSM-5 criteria throughout the range of depressive disorders. The aims of the present study were to 1) establish the lifetime prevalence of specific depressive disorders according to the new DSM-5 definitions in a community sample, and 2) determine their clinical relevance in terms of socio-demographic characteristics, comorbidity, course and treatment patterns. The semi-structured Diagnostic Interview for Genetic Studies was administered by masters-level psychologists to a random sample of an urban area (n=3720). The lifetime prevalence was 15.2% for PDD with persistent major depressive episode (MDE), 3.3% for PDD with pure dysthymia, 28.2% for Major Depressive Disorder (MDD) and 9.1% for OSDD. Subjects with PDD with persistent MDE were the most severely affected, followed by those with recurrent MDD, single episode MDD, PDD with pure dysthymia and OSDD and finally those without depressive disorders. Our data provide further evidence for the clinical significance of mild depressive disorders (OSDD), but cast doubt on the pertinence of lumping together PDD with persistent MDE and the former DSM-IV dysthymic disorder within the new PDD category

Study of γπ→ππ\gamma\pi \to \pi\pi below 1 GeV using Integral Equation Approach

The scattering of $\gamma \pi \to \pi \pi$ is studied using the axial anomaly, elastic unitarity, analyticity and crossing symmetry. Using the technique to derive the Roy's equation, an integral equation for the P-wave amplitude is obtained in terms of the strong P-wave pion pion phase shifts. Its solution is obtained numerically by an iteration procedure using the starting point as the solution of the integral equation of the Muskelshsvilli-Omnes type. It is, however, ambiguous and depends sensitively on the second derivative of the P-wave amplitude at $s=m_\pi^2$ which cannot directly be measured.Comment: 26 pages, 10 figure