A template-matching algorithm for laminar identification of cortical recording sites from evoked response potentials

In recent years, the advent of the so-called silicon probes has made it possible to homogeneously sample spikes and local field potentials (LFPs) from a regular grid of cortical recording sites. In principle, this allows inferring the laminar location of the sites based on the spatiotemporal pattern of LFPs recorded along the probe, as in the well-known current source-density (CSD) analysis. This approach, however, has several limitations, since it relies on visual identification of landmark features (i.e., current sinks and sources) by human operators, features that can be absent from the CSD pattern if the probe does not span the whole cortical thickness, thus making manual labeling harder. Furthermore, as with any manual annotation procedure, the typical CSD-based workflow for laminar identification of recording sites is affected by subjective judgment undermining the consistency and reproducibility of results. To overcome these limitations, we developed an alternative approach, based on finding the optimal match between the LFPs recorded along a probe in a given experiment and a template LFP profile that was computed using 18 recording sessions, in which the depth of the recording sites had been recovered through histology. We show that this method can achieve an accuracy of 79 \u3bcm in recovering the cortical depth of recording sites and a 76% accuracy in inferring their laminar location. As such, our approach provides an alternative to CSD that, being fully automated, is less prone to the idiosyncrasies of subjective judgment and works reliably also for recordings spanning a limited cortical stretch. NEW & NOTEWORTHY Knowing the depth and laminar location of the microelectrodes used to record neuronal activity from the cerebral cortex is crucial to properly interpret the recorded patterns of neuronal responses. Here, we present an innovative approach that allows inferring such properties with high accuracy and in an automated way (i.e., without the need of visual inspection and manual annotation) from the evoked response potentials elicited by sensory (e.g., visual) stimuli

Automated detection of extended sources in radio maps: progress from the SCORPIO survey

Automated source extraction and parameterization represents a crucial challenge for the next-generation radio interferometer surveys, such as those performed with the Square Kilometre Array (SKA) and its precursors. In this paper we present a new algorithm, dubbed CAESAR (Compact And Extended Source Automated Recognition), to detect and parametrize extended sources in radio interferometric maps. It is based on a pre-filtering stage, allowing image denoising, compact source suppression and enhancement of diffuse emission, followed by an adaptive superpixel clustering stage for final source segmentation. A parameterization stage provides source flux information and a wide range of morphology estimators for post-processing analysis. We developed CAESAR in a modular software library, including also different methods for local background estimation and image filtering, along with alternative algorithms for both compact and diffuse source extraction. The method was applied to real radio continuum data collected at the Australian Telescope Compact Array (ATCA) within the SCORPIO project, a pathfinder of the ASKAP-EMU survey. The source reconstruction capabilities were studied over different test fields in the presence of compact sources, imaging artefacts and diffuse emission from the Galactic plane and compared with existing algorithms. When compared to a human-driven analysis, the designed algorithm was found capable of detecting known target sources and regions of diffuse emission, outperforming alternative approaches over the considered fields.Comment: 15 pages, 9 figure

The MEV project: design and testing of a new high-resolution telescope for Muography of Etna Volcano

The MEV project aims at developing a muon telescope expressly designed for the muography of Etna Volcano. In particular, one of the active craters in the summit area of the volcano would be a suitable target for this experiment. A muon tracking telescope with high imaging resolution was built and tested during 2017. The telescope is a tracker based on extruded scintillating bars with WLS fibres and featuring an innovative read-out architecture. It is composed of three XY planes with a sensitive area of \SI{1}{m^2}; the angular resolution does not exceeds \SI{0.4}{\milli\steradian} and the total angular aperture is about $\pm$\SI{45}{\degree}. A special effort concerned the design of mechanics and electronics in order to meet the requirements of a detector capable to work in a hostile environment such as the top of a tall volcano, at a far distance from any facility. The test phase started in January 2017 and ended successfully at the end of July 2017. An extinct volcanic crater (the Monti Rossi, in the village of Nicolosi, about 15km from Catania) is the target of the measurement. The detector acquired data for about 120 days and the preliminary results are reported in this work

Piezoelectric Rainfall Energy Harvester Performance by Advanced Arduino based Measuring System

This paper presents the performances of rainfall energy harvesting through the use of a piezoelectric transducer and an Arduino-based measuring system. Different studies agree on the possibility of generating electricity from rainfall, but to date, a study on measuring the quantity of energy produced during rainfall is still missing. The present study begins with results obtained from laboratory researchers using piezoelectric transducers and oscilloscopes, finalized to measure the energy produced from a single raindrop, and concludes with an ad hoc Arduino-based measuring system, aimed to measure the actual amount of electrical energy produced by a piezoelectric transducer that is exposed to rainfall of variable durations

Exploring the multifaceted circumstellar environment of the luminous blue variable HR Carinae

Indexación: Web of Science; Scopus.We present a multiwavelength study of the Galactic luminous blue variable HR Carinae, based on new high-resolution mid-infrared (IR) and radio images obtained with the Very Large Telescope (VLT) and the Australia Telescope Compact Array (ATCA), which have been complemented by far-infrared Herschel-Photodetector Array Camera and Spectrometer (PACS) observations and ATCA archive data. The Herschel images reveal the large-scale distribution of the dusty emitting nebula, which extends mainly to the north-east direction, up to 70 arcsec from the central star, and is oriented along the direction of the space motion of the star. In the mid-infrared images, the brightness distribution is characterized by two arcshaped structures, tracing an inner envelope surrounding the central star more closely. At radio wavelengths, the ionized gas emission lies on the opposite side of the cold dust with respect to the position of the star, as if the ionized front were confined by the surrounding medium in the north-south direction. Comparison with previous data indicates significant changes in the radio nebula morphology and in the mass-loss rate from the central star, which has increased from 6.1 × 10-6M⊙ yr-1 in 1994-1995 to 1.17 × 10-5M⊙ yr-1 in 2014. We investigate possible scenarios that could have generated the complex circumstellar environment revealed by our multiwavelength data.https://academic.oup.com/mnras/article-lookup/doi/10.1093/mnras/stw307

5-Hydroxymethylcytosine Loss in Conjunctival Melanoma.

Conjunctival and cutaneous melanoma partially share similar clinical and molecular backgrounds. As 5-hydroxymethylcytosine (5-hmC) loss has been demonstrated in cutaneous melanoma, we decided to assess if similar changes were occurring in conjunctival melanoma. 5-methylcytosine (5-mC), 5-hmC and TET2 were respectively identified by immunohistochemistry and RNA ISH in 40 conjunctival nevi and 37 conjunctival melanomas. Clinicopathological correlations were established. 5-mC, TET2 and 5-hmC were respectively identified in 67.5%, 95% and 100% of conjunctival nevi and in 81.1%, 35.1% and 54% of conjunctival melanomas. A significant 5-hmC and TET2 loss was identified in conjunctival melanoma comparing to nevus, as well as a significant correlation between TET2 and 5-hmC expression. In the melanomas, 5-hmC expression was only significantly associated with local lymphatic invasion, but not with other clinicopathological parameters. There was a correlation between TET2 expression and the localization of the tumors. 5-mC expression was not associated with any clinicopathological parameters. We identified a significant 5-hmC loss in conjunctival melanoma similar to cutaneous melanoma. This loss may possibly be attributed to TET2 loss or IDH1 mutations. 5-hmC loss in conjunctival melanoma may help in the differential diagnosis between atypical conjunctival nevus and conjunctival melanoma

Vertex finding in ALICE by the use of silicon pixel layers in the Inner Tracking System

The performance of the Inner Tracking System of the ALICE detector for primary vertex estimation is discussed. A simulation study of the vertex reconstruction in ALICE through the information given by the two pixel layers is reported. Vertex resolution was studied as a function of the nominal vertex location and of the particle multiplicity

SCORPIO-II: Spectral indices of weak Galactic radio sources

In the next few years the classification of radio sources observed by the large surveys will be a challenging problem, and spectral index is a powerful tool for addressing it. Here we present an algorithm to estimate the spectral index of sources from multiwavelength radio images. We have applied our algorithm to SCORPIO (Umana et al. 2015), a Galactic Plane survey centred around 2.1 GHz carried out with ATCA, and found we can measure reliable spectral indices only for sources stronger than 40 times the rms noise. Above a threshold of 1 mJy, the source density in SCORPIO is 20 percent greater than in a typical extra-galactic field, like ATLAS (Norris et al. 2006), because of the presence of Galactic sources. Among this excess population, 16 sources per square degree have a spectral index of about zero, suggesting optically thin thermal emission such as Hii regions and planetary nebulae, while 12 per square degree present a rising spectrum, suggesting optically thick thermal emission such as stars and UCHii regions.Comment: 12 pages, 11 figures, accepted by MNRA

Tracking inside the ALICE Inner Tracking System

One of the main purposes of the ALICE Inner Tracking System (ITS) is to improve the resolution of the track parameters found in the main ALICE tracker detector, the Time Projector Chamber (TPC). Some results about tracking efficiency and resolution of track parameters obtained with a tracking code, based on the Kalman filter algorithm are presented