Robot-aided neurorehabilitation of the upper extremities

Task-oriented repetitive movements can improve muscle strength and movement co-ordination in patients with impairments due to neurological lesions. The application of robotics and automation technology can serve to assist, enhance, evaluate and document the rehabilitation of movements. The paper provides an overview of existing devices that can support movement therapy of the upper extremities in subjects with neurological pathologies. The devices are critically compared with respect to technical function, clinical applicability, and, if they exist, clinical outcome

Commitments to Give-if-you-Win Exceed Donations After a Win

Should fundraisers ask a banker to donate “if he earns a bonus” or wait and ask after the bonus is known? Standard EU theory predicts these are equivalent; loss-aversion and signaling models predict a larger commitment before the bonus is known; theories of affect predict the reverse. In five experiments incorporating lab and field elements (N=1363), we solicited donations from small lottery winnings , varying the conditionality of donations between participants. Overall, we find conditional donations (“if you win”) exceeded ex-post donations. This represents the first evidence on how pro-social behavior extends to conditional commitments over uncertain income, with implications for charitable fundraising, giving pledges, and experimental methodologyWe would like to thank the Universities of Essex, Düsseldorf, Mannheim and Bonn for providing financial support for our research

Phase-field modelling of ternary eutetic solidification in hot dip galvanization

Continuous hot dip galvanizing is one of the commercially most important process techniques used for protecting steel sheets against corrosion. Preheated steel sheets are con-tinuously drawn through a pot with a molten zinc alloy. After passing a gas jet that controls the layer thickness multiple cooling units act to cool down the sheet. During passing these aggregates nucleation, dendritic primary solidification and the formation of a binary and ter-nary eutectic occurs. In the present paper, the coupled modelling of macroscopic heat flow, multiphase thermodynamics and crystal growth during solidification of a Zn-2.5 wt.% Al-1.5 wt.% Mg alloy is presented. The heat flow problem requires a numerical domain in the order of meters, growth of primary Zn-dendrites in the order of several hundred micrometers, and the interdendritic eutectic in the order of several nanometers. For technical alloys like the ternary system considered here, a thermodynamic database has been online linked to a phase-field model to describe phase transformations including all occurring solid/liquid or sol-id/solid interfaces. Process simulations have been used for getting appropriate thermal bound-ary conditions for 3D phase field simulations which were performed at three different length-scales. For modelling primary dendritic Zn-a seed density model was used for predicting the grain structure within the Zn layer. At a smaller length-scale, a small part of a Zn-dendrite surface was taken as starting point for simulating the transition between primary binary eutec-tic and ternary eutectic coupled growth of Zn-rich, Al-rich, and MgZn2-phases. Finally, the morphology of the ternary eutectic has been evaluated at the smallest length scale. The com-parison with real solidification microstructure reveals encouraging agreements

Ex-ante Commitments to "Give if you Win" Exceed Donations After a Win

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Should fundraisers ask a banker to donate “if he earns a bonus” or wait and ask after the bonus is known? Standard EU theory predicts these approaches are equivalent; loss-aversion and signaling models predict a larger commitment before the bonus is known; theories of affect predict the reverse. In five experiments incorporating lab and field elements (N=1363), we solicited charitable donations from small lottery winnings, varying the conditionality of donations between participants. Pooling across experiments, participants are 23% more likely to commit to donate from the winning income and commit 25% more when asked before the lottery’s outcome is determined—relative to those asked to donate after they learn they have won. These differences are strongly statistically significant. This represents the first evidence on how pro-social behavior extends to conditional commitments over uncertain income, with implications for charitable fundraising, giving pledges, and experimental methodology.We would like to thank the Universities of Essex, Düsseldorf, Mannheim and Bonn for providing financial support for our research

Exploiting symmetries in SDP-relaxations for polynomial optimization

In this paper we study various approaches for exploiting symmetries in polynomial optimization problems within the framework of semi definite programming relaxations. Our special focus is on constrained problems especially when the symmetric group is acting on the variables. In particular, we investigate the concept of block decomposition within the framework of constrained polynomial optimization problems, show how the degree principle for the symmetric group can be computationally exploited and also propose some methods to efficiently compute in the geometric quotient.Comment: (v3) Minor revision. To appear in Math. of Operations Researc

Pay What You Want as a Marketing Strategy in Monopolistic and Competitive Markets

Pay What You Want (PWYW) can be an attractive marketing strategy to price discriminate between fair-minded and selfish customers, to fully penetrate a market without giving away the product for free, and to undercut competitors that use posted prices. We report on laboratory experiments that identify causal factors determining the willingness of buyers to pay voluntarily under PWYW. Furthermore, to see how competition affects the viability of PWYW, we implement markets in which a PWYW seller competes with a traditional seller. Finally, we endogenize the market structure and let sellers choose their pricing strategy. The experimental results show that outcome-based social preferences and strategic considerations to keep the seller in the market can explain why and how much buyers pay voluntarily to a PWYW seller. We find that PWYW can be viable in isolation, but it is less successful as a competitive strategy because it does not drive traditional posted-price sellers out of the market. Instead, the existence of a posted-price competitor reduces buyers’ payments and prevents the PWYW seller from fully penetrating the market. If given the choice, the majority of sellers opt for setting a posted price rather than a PWYW pricing. We discuss the implications of these results for the use of PWYW as a marketing strategy

Characterization of kinetic and kinematic parameters for wearable robotics

The design process of a wearable robotic device for human assistance requires the characterization of both kinetic and kinematic parameters (KKP) of the human joints. The first step in this process is to extract the KKP from different gait analyses studies. This work is based on the human lower limb considering the following activities of daily living (ADL): walking over ground, stairs ascending/descending, ramp ascending/descending and chair standing up. The usage of different gait analyses in the characterization process, causes the data to have great variations from one study to another. Therefore, the data is graphically represented using Matlab® and Excel® to facilitate its assessment. Finally, the characterization of the KKP performed was proved to be useful in assessing the data reliability by directly comparing all the studies between each other; providing guidelines for the selection of actuator capacities depending on the end application; and highlighting optimization opportunities such as the implementation of agonist-antagonist actuators for particular human joints

Design Understanding: From Logic to Specification

We present an outline of the field of Design Understanding and summarize state-of-the-art research in deriving human-understandable knowledge in form of logic properties from an unknown design

Use of Site-Specifically Tethered Chemical Nucleases to Study Macromolecular Reactions

During a complex macromolecular reaction multiple changes in molecular conformation and interactions with ligands may occur. X-ray crystallography may provide only a limited set of snapshots of these changes. Solution methods can augment such structural information to provide a more complete picture of a macromolecular reaction. We analyzed the changes in protein conformation and protein:nucleic acid interactions which occur during transcription initiation by using a chemical nuclease tethered to cysteines introduced site-specifically into the RNA polymerase of bacteriophage T7 (T7 RNAP). Changes in cleavage patterns as the polymerase steps through transcription reveal a series of structural transitions which mediate transcription initiation. Cleavage by tethered chemical nucleases is seen to be a powerful method for revealing the conformational dynamics of macromolecular reactions, and has certain advantages over cross-linking or energy transfer approaches

GOLPH2 expression may serve as diagnostic marker in seminomas

ABSTRACT: BACKGROUND: GOLPH2 (Golgi phosphoprotein 2) is a novel Golgi membrane protein. Despite its unknown physiologic function, however, it has been proposed as a biomarker for hepatocellular and prostate carcinoma due to its upregulation in those cancer entities. Whether the overexpression of GOLPH2 is tumour specific or a generic parameter of malignancy and whether this finding is true for additional carcinomas has not been determined. In this study, we aimed to evaluate the expression pattern of GOLPH2 in testicular seminomas, the most common histologic subtype of testicular neoplasm. METHODS: GOLPH2 protein expression was assessed by immunohistochemistry in 69 testicular seminomas and compared to the expression rates in matching normal testicular tissue and intratubular germ cell neoplasia of unclassified type (IGCNU). In addition, a subset of Leydig cell tumours was analyzed accordingly. RESULTS: GOLPH2 was consistently overexpressed (89.9%) in seminomas. Matching non-neoplastic tissue showed weak or negative staining. The observed differences between non-neoplastic and neoplastic tissue were statistically highly significant (p < 0.001). There were no significant associations with tumour status. Interestingly, GOLPH2 was also highly expressed in the intertubular Leydig cells as well as in Leydig cell tumours. CONCLUSIONS: GOLPH2 protein is highly expressed in seminomas and in Leydig cell tumours. This study fosters the association of GOLPH2 with malignant neoplastic processes. The staining pattern is easily assessable and consistent which is a favourable property especially in clinical settings. GOLPH2 could be a novel immunohistochemical marker for the assessment of testicular neoplasms, especially against the background that in analogy to hepatocellular carcinomas complementary GOLPH2 serum levels might be helpful in detecting metastases or recurrent tumour. Therefore serum studies and analyses of GOLPH2 expression in non-seminomatous germ cell tumours are strongly warranted