A process model for developing learning design patterns with international scope

This paper investigates the process of identifying design patterns in international collaborative learning environments. In this context, design patterns are referred to as structured descriptions of best practice with pre-defined sections such as problem, solution and consequences. We pay special attention to how the scope of a design pattern is identified and articulated. Based on a review of the seminal design patterns literature and current practice in the area of learning design, the lack of a more specific process description for developing patterns with international scope is identified. The paper suggests a process model for developing patterns with international scope. This model is exemplified in a case study that links the analysis of observation in international learning environments to the articulation of design patterns by identifying culturally independent core values that constitute the foundations of a design pattern with international scope. These core values are linked to recurrent learning behaviors and specific artefacts that support learning in the articulation of a design pattern. The findings contribute to gaining a deeper understanding of the pattern scoping and abstraction process in international learning environments

Concurrent administration of Docetaxel and Stealth® liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection

The substantial augmentation of the radiation sequelae during chemo–radiotherapy with novel drugs masks the real potential of such regimens. In this study we examined whether subcutaneous administration of amifostine can reduce the toxicity of a highly aggressive chemo–radiotherapy scheme with Stealth® liposomal doxorubicin (Caelyx®) and Docetaxel (Taxotere®) in non-small cell lung cancer. Twenty-five patients with stage IIIb non-small cell lung cancer were recruited in a phase I/II dose escalation trial. The starting dose of Taxotere® was 20 mg m−2 week and of Caelyx® was 15 mg m−2 every two weeks, during conventionally fractionated radiotherapy (total dose of 64 Gy). The dose of Taxotere®/Caelyx® was, thereafter, increased to 20/25 (five patients) and 30/25 mg m−2 (15 patients). Amifostine 500 mg was given subcutaneously before each radiotherapy fraction, while an i.v. amifostine dose of 1000 mg preceded the infusion of docetaxel. The ‘in-field’ radiation toxicity was low. Grade 3 esophagitis occurred in 9 out of 25 (36%) patients. Apart from a marked reduction of the lymphocyte counts, the regimen was deprived from any haematological toxicity higher than grade 1. No other systemic toxicity was noted. The CR and CR/PR rates in 15 patients treated at the highest dose level was 40% (6 out of 15) and 87% (13 out of 15) respectively. It is concluded that the subcutaneous administration of amifostine during high dose Taxotere®/Caelyx® chemo–radiotherapy is a simple and effective way to render this aggressive regimen perfectly well tolerated, by reducing the systemic and the ‘in-field’ toxicity to the levels expected from simple conventional radiotherapy. The impressive tolerance and the high CR rate obtained encourages the conduct of a relevant randomized trial to assess an eventual survival benefit in patients with non-small cell lung cancer

Severe community-acquired adenovirus pneumonia in an immunocompetent 44-year-old woman: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>This case report describes a rare condition: community-acquired adenovirus pneumonia in an immunocompetent adult. The diagnosis was achieved by using a multiplex real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay and highlights the usefulness of these novel molecular diagnostic techniques in patients hospitalized with acute respiratory illness. We also performed a literature search for previously published cases and present a summary of the clinical, laboratory and radiological features of this condition.</p> <p>Case presentation</p> <p>A 44-year-old immunocompetent Caucasian woman was admitted to our hospital with an acute febrile respiratory illness associated with a rash. Her blood tests were non-specifically abnormal, and tests for bacterial pathogens were negative. Her condition rapidly deteriorated while she was in our hospital and required mechanical ventilation and inotropic support. A multiplex real-time RT-PCR assay performed on respiratory specimens to detect respiratory viruses was negative for influenza but positive for adenovirus DNA. The patient recovered on supportive treatment, and antibiotics were stopped after 5 days.</p> <p>Conclusions</p> <p>Community-acquired adenovirus pneumonia in immunocompetent adult civilians presents as a non-specific acute febrile respiratory illness followed by the abrupt onset of respiratory failure, often requiring mechanical ventilation. Its laboratory and radiological features are typical of viral infections but also are non-specific. Novel multiplex real-time RT-PCR testing for respiratory viruses enabled us to rapidly make the diagnosis in this case. The new technology could be used more widely in patients with acute respiratory illness and has potential utility for rationalization of the use of antibiotics and improving infection control measures.</p

On the darkest pixel atmospheric correction algorithm: a revised procedure applied over satellite remotely sensed images intended for environmental applications

Atmospheric correction is an essential part of the pre-processing of satellite remote sensing data. Several atmospheric correction approaches can be found in the literature ranging from simple to sophisticated methods. The sophisticated methods require auxiliary data, however the simple methods are based only on the image itself and are served to be suitable for operational use. One of the most widely used and well-known simple atmospheric correction methods is the darkest pixel (DP). Despite of its simplicity, the user must be aware of several key points in order to avoid any erroneous results. Indeed, this paper addresses a new strategy for selecting the suitable dark object based on the proposed analysis of digital number histograms and image examination. Several case studies, in which satellite remotely sensed image data intended for environmental applications have been atmospherically corrected using the DP method, are presented in this article

Relationships of photosynthetically active radiation and shortwave irradiance

Hourly measurements of solar irradiance in the wave band excluding photosynthetically active radiation (PAR) and solar irradiance (SI) were made over a 12-month period at the National Observatory of Athens, for obtaining the ratios of PAR to SI. These irradiance ratios exhibit dependence on sky conditions, with slightly larger values being observed under &quot;cloudy&quot; skies and seasonal variations, attributable to changes in local air mass climatology. The highest values have been obtained during the growing season (April-September). The mean annual value of 0.473 observed for the irradiance ratio in the PAR band compares favorably with values reported in the literature for different locations over a wide geographical area. © 1993 Springer-Verlag

Dimming/brightening in Athens: Trends in Sunshine Duration, Cloud Cover and Reference Evapotranspiration

Evidence of global dimming/brightening is mainly based upon few measurements of solar radiation. A need for more research supported and extended with the use of other climatic variables, such as sunshine duration, recorded for a longer time period and successfully used as a proxy for solar radiation over the past 80 years, has already been urged. Thus, in this study, residual sunshine duration series computed after removal of the cloudiness-related variability, from daily sunshine duration and cloudiness data measured at the National Observatory of Athens are used for highlighting global dimming or brightening periods in Athens, during the period 1951-2001. Furthermore, the consistency of trends in radiation records and their implications for the hydrological cycle and especially the trends in reference evapotranspiration are examined, during the period 1951-2001. The analysis focuses on the seasonal decadal variations, determines and explains the causes of the seasonal trends from the inter-annual and decadal variability of the sunshine duration during the last half past century, with a special emphasis in detecting possible sub-periods in Athens. The signs of trends in the modeled annual and seasonal reference evapotranspiration are estimated, according to the indicated global dimming/brightening periods. © 2012 Springer Science+Business Media Dordrecht