533 research outputs found
Evaluation of radiography as a screening method for detection and characterisation of congenital vertebral malformations in dogs
Congenital vertebral malformations (CVM) are common in brachycephalic ‘screw-tailed’ dogs; they can be associated with neurological deficits and a genetic predisposition has been suggested. The purpose of this study was to evaluate radiography as a screening method for congenital thoracic vertebral malformations in brachycephalic ‘screw-tailed’ dogs by comparing it with CT. Forty-nine dogs that had both radiographic and CT evaluations of the thoracic vertebral column were included. Three observers retrospectively reviewed the images independently to detect CVMs. When identified, they were classified according to a previously published radiographic classification scheme. A CT consensus was then reached. All observers identified significantly more affected vertebrae when evaluating orthogonal radiographic views compared with lateral views alone; and more affected vertebrae with the CT consensus compared with orthogonal radiographic views. Given the high number of CVMs per dog, the number of dogs classified as being CVM free was not significantly different between CT and radiography. Significantly more midline closure defects were also identified with CT compared with radiography. Malformations classified as symmetrical or ventral hypoplasias on radiography were frequently classified as ventral and medial aplasias on CT images. Our results support that CT is better than radiography for the classification of CVMs and this will be important when further evidence of which are the most clinically relevant CVMs is identified. These findings are of particular importance for designing screening schemes of CVMs that could help selective breeding programmes based on phenotype and future studies
Gaussian noise and time-reversal symmetry in non-equilibrium Langevin models
We show that in driven systems the Gaussian nature of the fluctuating force
and time-reversibility are equivalent properties. This result together with the
potential condition of the external force drastically restricts the form of the
probability distribution function, which can be shown to satisfy
time-independent relations. We have corroborated this feature by explicitly
analyzing a model for the stretching of a polymer and a model for a suspension
of non-interacting Brownian particles in steady flow.Comment: 6 pages, submitted to PR
Prevalence of thoracic vertebral malformations in french bulldogs, pugs and english bulldogs with and without associated neurological deficits
Congenital vertebral malformations are common incidental findings in small breed dogs. This retrospective observational study evaluated the type and prevalence of thoracic vertebral malformations in 171 neurologically normal and 10 neurologically abnormal screw-tailed brachycephalic dogs. Neurologically normal dogs underwent CT for reasons unrelated to spinal disease, while affected dogs underwent MRI. Imaging studies were reviewed and vertebral malformations including hemivertebrae, block vertebrae, transitional vertebrae, and spina bifida were documented.
The group of clinically normal dogs consisted of 62 French bulldogs, 68 Pugs and 41 English bulldogs. The group of affected dogs consisted of one French bulldog and nine Pugs. Overall, 80.7% of neurologically normal animals were affected by at least one vertebral malformation. There was a significant influence of breed, with thoracic vertebral malformations occurring more often in neurologically normal French bulldogs (P < 0.0001) and English bulldogs (P = 0.002). Compared to other breeds, hemivertebrae occurred more often in neurologically normal French bulldogs (93.5%; P < 0.0001 vs. Pugs; P = 0.004 vs. English bulldogs) and less often in neurologically normal Pugs (17.6%; P = 0.004 vs. English bulldogs). Neurologically normal Pugs were more often diagnosed with transitional vertebrae and spina bifida compared to other breeds (P < 0.0001 for both malformations). Of Pugs included in the study, 4.7% were diagnosed with clinically relevant thoracic vertebral malformations. When compared to the general veterinary hospital population, this was significantly more than the other two breeds (P = 0.006). This study indicates that thoracic vertebral malformations occur commonly in neurologically normal screw-tailed brachycephalic dogs. While hemivertebrae are often interpreted as incidental diagnostic findings, they appear to be of greater clinical importance in Pugs compared to other screw-tailed brachycephalic breeds
Mapping the Wigner distribution function of the Morse oscillator into a semi-classical distribution function
The mapping of the Wigner distribution function (WDF) for a given bound-state
onto a semiclassical distribution function (SDF) satisfying the Liouville
equation introduced previously by us is applied to the ground state of the
Morse oscillator. Here we give results showing that the SDF gets closer to the
corresponding WDF as the number of levels of the Morse oscillator increases. We
find that for a Morse oscillator with one level only, the agreement between the
WDF and the mapped SDF is very poor but for a Morse oscillator of ten levels it
becomes satisfactory.Comment: Revtex, 27 pages including 13 eps figure
Microscopic Calculation of in-Medium Proton-Proton Cross Sections
We derive in-medium PROTON-PROTON cross sections in a microscopic model based
upon the Bonn nucleon-nucleon potential and the Dirac-Brueckner approach for
nuclear matter. We demonstrate the difference between proton-proton and
neutron-proton cross sections and point out the need to distinguish carefully
between the two cases. We also find substantial differences between our
in-medium cross sections and phenomenological parametrizations that are
commonly used in heavy-ion reactions.Comment: 9 pages of RevTex and 4 figures (postscript in separate uuencoded
file), UI-NTH-930
Gait analysis in French bulldogs with and without vertebral kyphosis
The study objective was to compare temporal-spatial and kinetic gait variables in neurologically normal French bulldogs with and without vertebral kyphosis. French bulldogs presented to a dedicated brachycephalic clinic were prospectively enrolled. All dogs underwent general physical, orthopaedic, and neurological examination prior to study inclusion. The presence of vertebral kyphosis was evaluated by computed tomography and kyphosis was defined as a Cobb angle exceeding 10°. Gait variables were collected using a pressure-sensitive GAITRite walkway with GAITFour software and included measurement of total pressure index (TPI) defined as the sum of peak pressure values recorded from each activated sensor by a paw during mat contact.
Fifteen French bulldogs with (n = 8) and without kyphosis (n = 7) were included. Cobb angle in kyphotic dogs ranged from 14.9° to 39.5°. Univariate analyses were initially performed to examine the association between kyphosis and 16 gait variables. When those variables found to be associated (P < 0.2) were taken forward into multivariate generalised linear mixed models (accounting for dog, velocity and side), kyphosis had a significant effect upon TPI of the forelimbs and TPI symmetry ratio (P < 0.05); however, the size of these effects was small. Although vertebral kyphosis is rarely associated with neurological deficits, it was associated with subtle alterations in kinetic gait variables (TPI forelimbs and TPI symmetry ratio). Further studies are needed to evaluate the clinical importance of altered gait variables in French bulldogs with kyphosis
'Relationship between thermal dose and cell death for "rapid" ablative and "slow" hyperthermic heating'.
Aim Thermal isoeffective dose (TID) has not been convincingly validated for application to predict biological effects from rapid thermal ablation (e.g., using >55 °C). This study compares the classical method of quantifying TID (derived from hyperthermia data) with a temperature-adjusted method based on the Arrhenius model for predicting cell survival in vitro, after either 'rapid' ablative or 'slow' hyperthermic exposures.Methods MTT assay viability data was obtained from two human colon cancer cell lines, (HCT116, HT29), subjected to a range of TIDs (120-720 CEM43) using a thermal cycler for hyperthermic (>2 minutes, 55 °C). TID was initially estimated using a constant RCEM>43°C=0.5, and subsequently using RCEM(T), derived from temperature dependent cell survival (injury rate) Arrhenius analysis.Results 'Slow' and 'rapid' exposures resulted in cell survival and significant regrowth (both cell lines) 10 days post-treatment for 240 CEM43 (RCEM>43°C=0.5), while 340-550 CEM43 (RCEM>43°C =0.5) delivered using 'rapid' exposures showed 12 ± 6% viability and 'slow' exposures resulted in undetectable viability. Arrhenius analysis of experimental data (activation energy ΔE = 5.78 ± 0.04 × 105 J mole-1, frequency factor A = 3.27 ± 11 × 1091 sec-1) yielded RCEM=0.42 * e0.0041*T which better-predicted cell survival than using R CEM> 43°C=0.5.Conclusions TID calculated using an RCEM(T) informed by Arrhenius kinetic parameters provided a more consistent, heating strategy independent, predictor of cell viability, improving dosimetry of ablative thermal exposures. Cell viability was only undetectable above 305 ± 10 CEM43 using this revised measure
Continuum Mechanics for Quantum Many-Body Systems: The Linear Response Regime
We derive a closed equation of motion for the current density of an
inhomogeneous quantum many-body system under the assumption that the
time-dependent wave function can be described as a geometric deformation of the
ground-state wave function. By describing the many-body system in terms of a
single collective field we provide an alternative to traditional approaches,
which emphasize one-particle orbitals. We refer to our approach as continuum
mechanics for quantum many-body systems. In the linear response regime, the
equation of motion for the displacement field becomes a linear fourth-order
integro-differential equation, whose only inputs are the one-particle density
matrix and the pair correlation function of the ground-state. The complexity of
this equation remains essentially unchanged as the number of particles
increases. We show that our equation of motion is a hermitian eigenvalue
problem, which admits a complete set of orthonormal eigenfunctions under a
scalar product that involves the ground-state density. Further, we show that
the excitation energies derived from this approach satisfy a sum rule which
guarantees the exactness of the integrated spectral strength. Our formulation
becomes exact for systems consisting of a single particle, and for any
many-body system in the high-frequency limit. The theory is illustrated by
explicit calculations for simple one- and two-particle systems.Comment: 23 pages, 4 figures, 1 table, 6 Appendices This paper is a follow-up
to PRL 103, 086401 (2009
Momentum-Dependent Mean Field Based Upon the Dirac-Brueckner Approach for Nuclear Matter
A momentum-dependent mean field potential, suitable for application in the
transport-model description of nucleus-nucleus collisions, is derived in a
microscopic way. The derivation is based upon the Bonn meson-exchange model for
the nucleon-nucleon interaction and the Dirac-Brueckner approach for nuclear
matter. The properties of the microscopic mean field are examined and compared
with phenomenological parametrizations which are commonly used in
transport-model calculations.Comment: 15 pages text (RevTex) and 4 figures (postscript in a separate
uuencoded file), UI-NTH-930
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