Analyzing the Effect of Time in Migration Measurement Using Georeferenced Digital Trace Data

Georeferenced digital trace data offer unprecedented flexibility in migration estimation. Because of their high temporal granularity, many migration estimates can be generated from the same data set by changing the definition parameters. Yet despite the growing application of digital trace data to migration research, strategies for taking advantage of their temporal granularity remain largely underdeveloped. In this paper, we provide a general framework for converting digital trace data into estimates of migration transitions and for systematically analyzing their variation along a quasi-continuous time scale, analogous to a survival function. From migration theory, we develop two simple hypotheses regarding how we expect our estimated migration transition functions to behave. We then test our hypotheses on simulated data and empirical data from three platforms in two internal migration contexts: geotagged Tweets and Gowalla check-ins in the United States, and cell-phone call detail records in Senegal. Our results demonstrate the need for evaluating the internal consistency of migration estimates derived from digital trace data before using them in substantive research. At the same time, however, common patterns across our three empirical data sets point to an emergent research agenda using digital trace data to study the specific functional relationship between estimates of migration and time and how this relationship varies by geography and population characteristics

Technoscientia est Potentia?: Contemplative, interventionist, constructionist and creationist idea(l)s in (techno)science

Within the realm of nano-, bio-, info- and cogno- (or NBIC) technosciences, the ‘power to change the world’ is often invoked. One could dismiss such formulations as ‘purely rhetorical’, interpret them as rhetorical and self-fulfilling or view them as an adequate depiction of one of the fundamental characteristics of technoscience. In the latter case, a very specific nexus between science and technology, or, the epistemic and the constructionist realm is envisioned. The following paper focuses on this nexus drawing on theoretical conceptions as well as empirical material. It presents an overview of different technoscientific ways to ‘change the world’—via contemplation and representation, intervention and control, engineering, construction and creation. It further argues that the hybrid character of technoscience makes it difficult (if not impossible) to separate knowledge production from real world interventions and challenges current science and technology policy approaches in fundamental ways

Learning from Data Journeys

This is the final version. Available on open access from Springer via the DOI in this recordThis chapter discusses the idea of data journeys as an investigative tool and a theoretical framework for this volume and broader scholarship on data. Building on a relational and historicized understanding of data as lineages, I reflect on the methodological, conceptual and social challenges involved in mapping, analysing and comparing the production, movement and use of data within and across research fields - and some of the strategies developed to cope with such difficulties. I then provide an overview of the significant variation among the data practices garnered in this volume. Specific nodes of difference and similarity across data journeys are identified, while also emphasising the extent to which such commonalities are dependent on specific situations of inquiry. In closing, I highlight the significance of this approach towards addressing concerns raised by data-centric science and the emergence of big and open data.European CommissionAlan Turing Institut

Governing Capital, Labor and Nature in a Changing World

This chapter attempts a broad analytical compass for surveying the main actors, institutions and instruments governing our world. Despite its seeming ubiquity, governance is a relatively new expression in this context suggestive both of new modes of exercising power, and an enhanced focus on ordering a world undergoing rapid change. Speaking generally governance may be understood as the exercise of power organized around multiple dispersed sites operating through transnational networks of actors, public as well as private, and national, regional as well as local. The turn to governance is often held to be coeval if not conjoined to profound changes in the meaning and nature of government associated with the ascendancy of ‘neo-liberal’ ideas and precepts. This has had significant implications for how governance tends to be understood. Critics associate it directly with the changing role of states in the economic and social sphere. Transnational governance, in particular, is criticized for foregrounding the priorities of corporate investors often to the detriment of social or environmental goals, subordinating principles of ‘comparative’ or ‘cooperative’ advantage to ‘competitive’ advantage, and promoting microregulatory forms of regulation over strategic or structurally-focused interventions (such as industrial policy). Associated shifts trace states’ powers, otherwise a touchstone of sovereignty, being increasingly negotiated with transnational private actors and international financial institutions (IFIs), and placed under external jurisdictions. The turn to governance tends also to framed, whether directly or directly, justifiably or otherwise, alongside cuts in the public provisioning of health, education, housing, and social expenditures wherever they may have taken place, a parallel proliferation of managerial controls, and to governments contracting out public services to private and quasi-private agencies, or relinquishing them to the voluntary sector. At the risk of oversimplifying its critics’ views, if modern governments describe rule by/of citizens, governance describes rule over subjects. This chapter maps a rather more fluid and differentiated landscape of governance across the five areas it surveys, i.e. finance, investment, trade, labor and environment. In finance, while regulation may appear to have become more transnational and to an extent even voluntary, deregulatory outcomes have reconfigured the nature of risk and the cognitive and policy frameworks for dealing with it. At the same time a growing risk of states having to foot the ultimate bill may still become a point of departure for more differentiated regulatory approaches. On the other hand, not only are environmental agreements continued to be implemented and enforced at national and sub-national scales, the ascendency of market interventions and transnational institutions here has taken place in parallel with—and sometimes through mutual cooptation of—other kinds of interventions including those for promoting decentralization and community control over resources. Trends in labor regulation may also reflect individual state choices more than direct transnational pressures, or run contrary to the preferences of specialized international organizations in the domain. Even in the controversial sphere of investment treaties, there is considerable ongoing fluidity with regard to norms, jurisdiction, and actors within and between national and international arenas. Thus, upon closer inspection and with the benefit of a more domain-specific approach, we may not necessarily observe a sweeping or uniform shift, but more a mosaic of regulatory frameworks, quite disparate trends with regard to their negotiation, implementation and impact, and a future rife with possibilities

Identification et impact de la sarcopénie chez les patients en surpoids et obèses avec un carcinome à cellules rénales localisé.

International audienc

Vers une philosophie des technosciences

International audienceThe term " technoscience " gained philosophical significance in the 1970s but it aroused ambivalent views. On the one hand, several scholars have used it to shed light on specific features of recent scientific research, especially with regard to emerging technologies that blur boundaries (such as natural/artificial, machine/living being, knowing/making and so on); on the other hand, as a matter of fact " technoscience " did not prompt great interest among philosophers. In the French area, a depreciative meaning prevails: " technoscience " means the contamination of science by management and capitalism. Some even argue that " technoscience " is not a concept at all, just a buzzword. In this chapter, on the contrary, we make the case for the constitution of a philosophical concept of technoscience based on the characterization of its objects in order to scrutinize their epistemological, ontological, political and ethical dimensions

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

Contains fulltext : 229588.pdf (Publisher’s version ) (Open Access)Around the tenth day after diagnosis, ∼20% of patients with coronavirus disease 2019 (COVID-19)-associated pneumonia evolve toward severe oxygen dependence (stage 2b) and acute respiratory distress syndrome (stage 3) associated with systemic inflammation often termed a "cytokine storm." Because interleukin-1 (IL-1) blocks the production of IL-6 and other proinflammatory cytokines, we treated COVID-19 patients early in the disease with the IL-1 receptor antagonist, anakinra. We retrospectively compared 22 patients from three different centers in France with stages 2b and 3 COVID-19-associated pneumonia presenting with acute severe respiratory failure and systemic inflammation who received either standard-of-care treatment alone (10 patients) or combined with intravenous anakinra (12 patients). Treatment started at 300 mg⋅d(-1) for 5 d, then tapered with lower dosing over 3 d. Both populations were comparable for age, comorbidities, clinical stage, and elevated biomarkers of systemic inflammation. All of the patients treated with anakinra improved clinically (P < 0.01), with no deaths, significant decreases in oxygen requirements (P < 0.05), and more days without invasive mechanical ventilation (P < 0.06), compared with the control group. The effect of anakinra was rapid, as judged by significant decrease of fever and C-reactive protein at day 3. A mean total dose of 1,950 mg was infused with no adverse side effects or bacterial infection. We conclude that early blockade of the IL-1 receptor is therapeutic in acute hyperinflammatory respiratory failure in COVID-19 patients