New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury

Advancements in pediatric dialysis generally rely on adaptation of technology originally developed for adults. However, in the last decade, particular attention has been paid to neonatal extracorporeal therapies for acute kidney care, an area in which technology has made giant strides in recent years. Peritoneal dialysis (PD) is the kidney replacement therapy (KRT) of choice in the youngest age group because of its simplicity and effectiveness. However, extracorporeal blood purification provides more rapid clearance of solutes and faster fluid removal. Hemodialysis (HD) and continuous KRT (CKRT) are thus the most used dialysis modalities for pediatric acute kidney injury (AKI) in developed countries. The utilization of extracorporeal dialysis for small children is associated with a series of clinical and technical challenges which have discouraged the use of CKRT in this population. The revolution in the management of AKI in newborns has started recently with the development of new CKRT machines for small infants. These new devices have a small extracorporeal volume that potentially prevents the use of blood to prime lines and dialyzer, allow a better volume control and the use of small-sized catheter without compromising the blood flow amount. Thanks to the development of new dedicated devices, we are currently dealing with a true “scientific revolution” in the management of neonates and infants who require an acute kidney support

The Luminosity Function of Cluster Galaxies. III

We investigated the optical properties of 7 clusters of galaxies observed in three colors over the range of absolute magnitudes -24 < M < -12. Our aim is to estimate the Luminosity Function and the total cluster luminosity of our sample in order to have information about the formation and the evolution of galaxies in clusters. In this paper, we present the main points of our analysis and give the formal parameters obtained by fitting the data using the maximum likelihood algorithm. We find consistency between our results and other works in literature confirming the bimodal nature of the luminosity function of cluster galaxies. More important, we find that the relation L_opt/ L_X versus L_X is color dependent: Low X ray Luminosity clusters have a bluer galaxy population.Comment: 22 pages. Accepted for publication on A&

Dieta frugívora dos gêneros de morcegos Artibeus, Carollia e Sturnira (Phyllostomidae, Chiroptera) ao longo de sua distribuição geográfica.

Editores técnicos: Marcílio José Thomazini, Elenice Fritzsons, Patrícia Raquel Silva, Guilherme Schnell e Schuhli, Denise Jeton Cardoso, Luziane Franciscon. EVINCI. Resumos

Consistency in fruit preferences across the geographical range of the frugivorous bats Artibeus, Carollia and Sturnira (Chiroptera).

Os filostomídeos frugívoros Artibeus, Carollia e Sturnira são importantes dispersores de sementes na região Neotropical, se destacando por possuírem uma suposta preferência por frutos dos gêneros Ficus, Piper e Solanum, respectivamente. Nós realizamos uma metanálise para testar a hipótese de que as interações entre esses morcegos e plantas são consistentes ao longo de toda sua distribuição geográfi ca. Por meio de uma extensa revisão bibliográfi ca, foram compilados 4.448 registros de consumo de frutos provenientes de 180 publicações. Estes dados foram organizados por espécie de morcego e país, testando quais gêneros de frutos foram mais frequentes na região neotropical como um todo e em cada um dos seus países componentes. Num panorama geral, os resultados demonstraram alta frequência no consumo de Ficus (24,0%) por Artibeus, Piper (38,7%) por Carollia e Solanum (31,0%) por Sturnira, considerando 176 gêneros botânicos citados. O estudo corrobora, assim, a hipótese da consistência da dieta desses morcegos ao longo de toda a sua distribuição geográfi ca, sendo esta relacionada à ampla distribuição dos grupos (morcegos e plantas) envolvidos, à fenologia das espécies zoocóricas consumidas e à fi delidade espacial dos morcegos, esta, por sua vez, moldada pela capacidade de voo das diferentes espécies

How chemical compounds affect fruit bats' plant interactions.

Fruit bats are known to be able to discriminate, select, and track the essential oils of their preferred fruits. A few years ago, our research group hypothesized, experimented, and confirmed that these bats can be attracted with essential oils only – concentrated volatile aromas – of their preferred fruits both in forested and open areas. These findings led to the proposal of a restoration tool that uses essential oils of chiropterochoric fruits (fruits eaten by bats) to attract seed-dispersing bats to degraded areas with the objective to increase seed arrival and germination.bitstream/item/206340/1/How-Chemical-Compounds-Affect-Fruit-Bats-Plant-Interactions.pd

INTEGRAL/RossiXTE high-energy observation of a state transition of GX 339-4

On 2004 August 15, we observed a fast (shorter than 10 hours) state transition in the bright black-hole transient GX 339-4 simultaneously with RossiXTE and INTEGRAL. This transition was evident both in timing and spectral properties. Combining the data from PCA, HEXTE and IBIS, we obtained good quality broad-band (3-200 keV) energy spectra before and after the transition. These spectra indicate that the hard component steepened. Also, the high-energy cutoff that was present at ~70 keV before the transition was not detected after the transition. This is the first time that an accurate determination of the broad-band spectrum across such a transition has been measured on a short time scale. It shows that, although some spectral parameters do not change abruptly through the transition, the high-energy cutoff increases/disappears rather fast. These results constitute a benchmark on which to test theoretical models for the production of the hard component in these systems.Comment: Accepted for publication in MNRAS (9 pages, 6 figures

Vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis

In this study, we sought to find novel bacterial and metabolic hallmarks for bacterial vaginosis (BV). We studied the vaginal microbiome and metabolome of vaginal fluids from BV-affected patients (n = 43) and healthy controls (n = 37) by means of an integrated approach based on quantitative polymerase chain reaction (qPCR) and proton nuclear magnetic resonance ((1)H-NMR). The correlations between the clinical condition and vaginal bacterial communities were investigated by principal component analysis (PCA). To define the metabolomics signatures of BV, 100 discriminant analysis by projection on latent structure (PLS-DA) models were calculated. Bacterial signatures distinguishing the health condition and BV were identified by qPCR. Lactobacillus crispatus strongly featured the healthy vagina, while increased concentrations of Prevotella, Atopobium and Mycoplasma hominis specifically marked the infection. (1)H-NMR analysis has led to the identification and quantification of 17 previously unreported molecules. BV was associated with changes in the concentration of metabolites belonging to the families of amines, organic acids, short chain fatty acids, amino acids, nitrogenous bases and monosaccharides. In particular, maltose, kynurenine and NAD(+) primarily characterised the healthy status, while nicotinate, malonate and acetate were the best metabolic hallmarks of BV. This study helps to better understand the role of the vaginal microbiota and metabolome in the development of BV infection. We propose a molecular approach for the diagnosis of BV based on quantitative detection in the vaginal fluids of Atopobium, Prevotella and M. hominis, and nicotinate, malonate and acetate by combining qPCR and (1)H-NMR

Binge eating attitudes in community adolescent sample and relationships with interview-assessed attachment representations in girls: a multi-center study from North Italy

Purpose: To compare community girls at risk and not at risk for binge eating (BE) in attachment representations through a narrative interview and to test the predictive role of attachment pattern(s) on the risk of binge eating among community girls. Methods: From 772 community adolescents of both sexes (33% boys) screened through the Binge Eating Scale (BES), 112 girls between 14 and 18&nbsp;years, 56 placed in a group at risk for binge eating (BEG), and 56 matched peers, not at risk (NBEG), were assessed in attachment representations through the Friends and Family Interview (FFI). Results: (1) Compared to NBEG, girls in the BEG showed more insecure-preoccupied classifications and scores, together with lower narrative coherence, mother\u2019s representation as a secure base/safe haven, reflective functioning, adaptive response, and more anger toward mother. (2) Both insecure-dismissing and preoccupied patterns predicted 15% more binge-eating symptoms in the whole sample of community girls. Conclusions: Insecure attachment representations are confirmed risk factors for more binge eating, affecting emotional regulation and leading to \u201cemotional eating\u201d, thus a dimensional assessment of attachment could be helpful for prevention and intervention. Implications and limits are discussed. Level of evidence: III. Evidence obtained from cohort or case\u2013control analytic studie

Human Breast Milk: A Source of Potential Probiotic Candidates

This study focuses on the isolation of lactobacilli/bifidobacteria from human breast milk and their first characterization, in the perspective to find new probiotic candidates to be included in food products. More specifically, breast-milk-isolated strains demonstrated a very good aptitude to adhere to intestinal cells, in comparison with L. rhamnosus GG strain, taken as reference. The same behavior has been found for hydrophobicity/auto-aggregation properties. A remarkable antagonistic activity was detected for these isolates not only against spoilage and pathogenic species of food interest, but also against the principal etiological agents of intestinal infections. Indeed, isolated strains impaired spoilage and pathogenic species growth, as well as biofilm formation by gut pathogens. In addition, breast milk strains were characterized for their antibiotic susceptibility, displaying species-specific and strain-specific susceptibility patterns. Finally, to assess their technological potential, the fermentation kinetics and viability of breast milk strains in pasteurized milk were investigated, also including the study of the volatile molecule profiles. In this regard, all the strains pointed out the release of aroma compounds frequently associated with the sensory quality of several dairy products such as acetic acid, diacetyl, acetoin, acetaldehyde. Data here reported point up the high potential of breast-milk-isolated strains as probiotics