Experiences of Patients With Auditory Processing Disorder in Getting Support in Health, Education, and Work Settings: Findings From an Online Survey

OBJECTIVE: To explore the views and experiences of individuals with Auditory Processing Disorder (APD) and/or their families in getting support from services and to receive their suggestions for improvement. DESIGN: Cross-sectional random sample survey with descriptive analysis. SETTINGS: Online survey. PARTICIPANTS: One hundred and fifty six individuals with APD and/or their family members from the APD Support UK patient support organization and four associated APD Facebook groups. MAIN OUTCOME MEASURE: A 16-item questionnaire on negative and positive experiences in getting a referral for diagnosis, funding for the FM system, and overall support for APD. RESULTS: The key findings that emerged included reports of difficulty in getting a referral for diagnosis (54%), obtaining funding for an FM system (45%), getting support for APD (61%), and poor recognition and awareness of APD (63%) in Education, Health or Work settings. The positive experiences reported were ease in getting a referral for diagnosis (46%), in obtaining an FM system (20%), and with diagnosis leading to help at school or to a better understanding of the condition and the required adjustments. The recommended improvement areas were raising awareness of APD and related management in Education (30%), the Health sector (25%), and the public (18%). CONCLUSIONS: Individuals and families of individuals with APD overwhelmingly report a lack of awareness of APD across health, education, and work sectors, and difficulties in getting access to diagnosis and support. This information may provide an initial understanding of the patients' needs for clinical services for APD, identify research priorities, and influence longer-term public health decisions toward improved care

The Introduction of a Multimodal Clinical Pathway for Outpatient Total Knee Arthroplasty in the Era of COVID-19

The combination of a short acting spinal and muscle-sparing regional blocks, including adductor canal and iPACK blocks, can allow for successful outpatient total knee arthroplasty.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1050/thumbnail.jp

Punzones de hueso de Odocoileus virginianus (Artiodactyla: Cervidae) de un depósito arqueológico del Posclásico temprano en la costa de Jalisco, México

Punches made with metapodial bones of white-tailed deer (Odocoileus virginianus) found at the Arroyo Piedras Azules archaeological site (1215 AD) in western central Mexico are described. It is speculated that they were used for clothing manufacturing, use on looms, or body piercing.Se describen punzones elaborados con huesos metapodiales de venado cola blanca (Odocoileus virginianus) encontrados en el sitio arqueológico Arroyo Piedras Azules (1215 de nuestra era) del centro occidente de México. Se especula que fueron utilizados para fabricación de vestimentas, uso en telares o perforaciones corporales

Contas de ossos de ave em um depósito arqueológico do Pós-clássico inicial (1215 EC) do ocidente do México

Se describe y comenta el hallazgo de cuentas de hueso de ave en el sitio arqueológico Arroyo Piedras Azules en la costa norte de Jalisco en el occidente de México (1215 ± 30 EC). Los dos fragmentos tubulares corresponden a la ulna. Probablemente, los huesos son cuentas que formaban parte de un collar o brazalete para uso ornamental.We describe and comment upon bird bone beads found at the Arroyo Piedras Azules archaeological site (1215 ± 30 AD), located on the northern coast of Jalisco in central Mexico. The two tubular fragments correspond to the ulna. The bones are probably beads that were part of a necklace or bracelet for ornamental use.A descoberta de contas de osso de ave no sítio arqueológico Arroyo Piedras Azules na costa norte de Jalisco, no oeste do México (1215 ± 30 dC) é descrita e discutida. Os dois fragmentos tubulares correspondem a ulna. Provavelmente, os ossos são contas que faziam parte de um colar ou pulseira para uso ornamental.Facultad de Ciencias Naturales y Muse

Accurate sample assignment in a multiplexed, ultrasensitive, high-throughput sequencing assay for minimal residual disease

High-throughput sequencing (HTS) (next-generation sequencing) of the rearranged Ig and T-cell receptor genes promises to be less expensive and more sensitive than current methods of monitoring minimal residual disease (MRD) in patients with acute lymphoblastic leukemia. However, the adoption of new approaches by clinical laboratories requires careful evaluation of all potential sources of error and the development of strategies to ensure the highest accuracy. Timely and efficient clinical use of HTS platforms will depend on combining multiple samples (multiplexing) in each sequencing run. Here we examine the Ig heavy-chain gene HTS on the Illumina MiSeq platform for MRD. We identify errors associated with multiplexing that could potentially impact the accuracy of MRD analysis. We optimize a strategy that combines high-purity, sequence-optimized oligonucleotides, dual indexing, and an error-aware demultiplexing approach to minimize errors and maximize sensitivity. We present a probability-based, demultiplexing pipeline Error-Aware Demultiplexer that is suitable for all MiSeq strategies and accurately assigns samples to the correct identifier without excessive loss of data. Finally, using controls quantified by digital PCR, we show that HTS-MRD can accurately detect as few as 1 in 10(6) copies of specific leukemic MRD

Modelling the Onset of Phase Separation in CaO-SiO2-CaCl2 Chlorine-Containing Silicate Glasses

The addition of chlorine into a bioactive glass composition is expected to reduce its abrasiveness and increase its bioactivity which is important for dental applications such as toothpastes. There is a lack of information and understanding regarding the structural role of chlorine in chlorine-containing bioactive silicate glasses. This has prompted classical core-shell model molecular dynamics simulations of (50-x/2)CaO-(50-x/2)SiO2-xCaCl2 glasses to be performed, where x ranges from x=0.0 to x=43.1 mol% CaCl2. These ternary glasses are advantageous for a fundamental study because they do not have additional network former (e.g. phosphorus) or modifier (e.g. sodium) ions typically found in bioactive glass compositions. The (50-x/2)CaO-(50-x/2)SiO2-xCaCl2 glasses were seen to become phase separated around the x=16.1 mol% CaCl2 composition and chlorine predominantly coordinated with calcium. These findings provide a solid foundation for further computational modelling work on more complex chlorine-containing bioactive glass compositions

Atomic-Scale Structural Characterization of Silver-Doped Phosphate-Based Glasses Prepared by Coacervation

Phosphate-based glasses (PBGs) are traditionally prepared using the high temperature melt quenching route (MQ) or via the more recent sol-gel method (SG) that requires the use of organic solvents. The coacervation method represents an excellent inexpensive and green alternative to MQ and SG, being performed in aqueous solution and at room temperature. Coacervation is particularly applicable for the production of PBGs designed for biomedical applications, because it allows for the inclusion of temperature sensitive molecules and it does not require the use of toxic solvents. Whereas the atomic structure of the melt quenched and sol-gel PBGs is known, the atomic structure of those prepared via coacervation has yet to be investigated. In this study, a comprehensive advanced structural characterization has been performed on phosphate-based glasses in the system P2O5–CaO–Na2O–Ag2O (Ag2O mol% = 0, 1, 3, 5, 9 and 14) prepared via the coacervation method. Glasses within this system should find application as bioresorbable biomaterials thanks to their ability to release bioactive ions in a controlled manner. In particular, they possess antibacterial properties, inferred by the release of Ag+ over time. High energy X-ray diffraction (HEXRD), 31P and 23Na solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and X-ray Absorption (XAS) at the Ag K-edge were used to probe the atomic structure of the glasses after drying in vacuum and after calcination at 300 °C. The length of the polyphosphate chains in the solid state appears to be independent of silver concentration, however, significant degradation of these chains is seen after calcination at 300 °C. Atomic-scale structure results indicate that the structure of these glasses is akin to that of other silver doped phosphate glasses prepared using the MQ and SG method. This suggests that phosphate-based glasses prepared using milder and greener conditions may have similar chemical and physical properties such as solubility, biocompatibility, and antibacterial properties