304 research outputs found
Social pharmacology: expanding horizons
In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so‑called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far‑reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of
therapy, while minimizing negative social consequences
Social pharmacology: expanding horizons
In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so‑called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far‑reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of
therapy, while minimizing negative social consequences
Vehicular mm-Wave Array for Smart Handover
[EN] The emergence of new technologies such as autonomous
vehicles and high data rate 5G networks requires advanced
antenna types that are capable of fulfilling requirements for
highly demanding wireless communication links. The array of
microstrip-fed slot-coupled patches is one such type of antenna
that provides low return loss and good transient behaviour for
broadband applications. A compact size slot-coupled patch
antenna subarray and its phased array is proposed in this paper.
Two different substrates Rogers TMM4 and Green TapeTM 951
Low Temperature Co-Fired Ceramic (LTCC) are considered for
the fabrication of microstrip feedline. The feedline is fabricated
on the respective substrates and then mounted on a Rogers
RT/duroid 5880 laminate. Ground planes are used on both the
front and backside of the antenna array. The antenna is operating
in a range of 24.25 GHz - 29.5 GHz. A Smart Array is proposed
in this paper which has a good performance in terms of antenna
gain and scanning property for 5G application in Smart
handovers.This work was partly funded by the Ministerio de Ciencia e
Innovacion (MICINN) under projects TEC2016-78028-C3-1-
P, PID 2019-107885GB-C31, MDM2016-0600, and Catalan
Research Group 2017 SGR 219.Bharath Reddy, G.; Ramirez, GA.; Molins-Benlliure, J.; Ferrando Bataller, M.; Romeu, J.; Jofre-R., L. (2020). Vehicular mm-Wave Array for Smart Handover. Universidad de Málaga. 1-4. http://hdl.handle.net/10251/178564S1
Bis(1,3-dibenzylimidazolium) μ-oxido-bis[trichloridoferrate(III)]
In the title compound (C17H17N2)2[Fe2Cl6O], obtained from the solid-state reaction of FeCl2 and N,N′-dibenzylimidazolium chloride, the complex anion has approximate D
3d symmetry with crystallographically imposed inversion symmetry coincident with the bridging μ-O atom. The stereochemistry about each FeCl3O centre is distorted tetrahedral [Fe—Cl = 2.2176 (5)–2.2427 (5) Å and Fe—O = 1.7545 (2) Å]. The Cl atoms are involved in weak anion–cation C—H⋯Cl interactions, giving a network structure
Influence of Si substitution on the reactivity of a-tricalcium phosphate
Silicon substituted calcium phosphates have been widely studied over the last ten years due to their enhanced osteogenic properties. Notwithstanding, the role of silicon on a-TCP reactivity is not clear yet. Therefore, the aim of this work was to evaluate the reactivity and the properties of Si-a-TCP in comparison to a-TCP. Precursor powders have similar properties regarding purity, particle size distribution and specific surface area, which allowed a better comparison of the Si effects on their reactivity and cements properties. Both Si-a-TCP and a-TCP hydrolyzed to a calcium-deficient hydroxyapatite when mixed with water but their conversion rates were different. Si-a-TCP exhibited a slower setting rate than a-TCP, i.e. kSSA for Si-TCP (0.021 g·m- 2·h- 1) was almost four times lower than for a-TCP (0.072 g·m- 2·h- 1). On the other hand, the compressive strength of the CPC resulting from fully reacted Si-a-TCP was significantly higher (12.80 ± 0.38 MPa) than that of a-TCP (11.44 ± 0.54 MPa), due to the smaller size of the entangled precipitated apatite crystals.Preprin
Moody's Correlated Binomial Default Distributions for Inhomogeneous Portfolios
This paper generalizes Moody's correlated binomial default distribution for
homogeneous (exchangeable) credit portfolio, which is introduced by Witt, to
the case of inhomogeneous portfolios. As inhomogeneous portfolios, we consider
two cases. In the first case, we treat a portfolio whose assets have uniform
default correlation and non-uniform default probabilities. We obtain the
default probability distribution and study the effect of the inhomogeneity on
it. The second case corresponds to a portfolio with inhomogeneous default
correlation. Assets are categorized in several different sectors and the
inter-sector and intra-sector correlations are not the same. We construct the
joint default probabilities and obtain the default probability distribution. We
show that as the number of assets in each sector decreases, inter-sector
correlation becomes more important than intra-sector correlation. We study the
maximum values of the inter-sector default correlation. Our generalization
method can be applied to any correlated binomial default distribution model
which has explicit relations to the conditional default probabilities or
conditional default correlations, e.g. Credit Risk, implied default
distributions. We also compare some popular CDO pricing models from the
viewpoint of the range of the implied tranche correlation.Comment: 29 pages, 17 figures and 1 tabl
Metallation of Isatin (2,3-Indolinedione). X-Ray Structure and Solution Behavior of Bis(Isatinato)Mercury(II)
The first X-ray structure of an isatin (2,3-indolinedione, isaH) metal complex,
bis(isatinato)memury(II) (C16H8N2O4Hg) (1), was determined. (1) was obtained from the reaction of
isaH with mercury(II) acetate in methanol. Analogously, treatment of sodium saccharinate and mercury(II) acetate in methanol yielded Hg(saccharinato)2•0.5CH3OH (3). (1) crystallizes in the monoclinic system, space group P21/ a with a = 7.299(1) Å, b
= 8.192(1) Å, c
= 11.601(1) Å , β = 105.82(1)°, V = 667.4 Å3, Z = 2, Dcalc = 2.452 g cm−3, MoKα radiation(λ = 0.71073 Å), μ = 115.5 cm-1, F(000) = 460, 21(1) °C. The structure was refined on the basis of 2023 observed reflections
to R= 0.044. The two deprotonated, non coplanar isa ligands are trans to each other in a head to
tail orientation and bound to the Hg through the nitrogen in a linear N-Hg-N arrangement. The Hg
atom is at the center of symmetry of the complex and displaced by 0.62 Å from the two planes of the
isa ligands (τ Hg-N1-C2-O2= -16°). The Hg-N bond length is 2.015 Å. Noπ-aryl-memury(ll)-π-aryl stacking interaction was observed either in the solid state or in the solution state. The IR, electronic,
and 1H
and 13CNMR spectral data of (1) and (3) suggest binding of the memury to the heterocyclic
nitrogen, in agreement with the crystal structure determination of (1)
Smart Beam Management for Vehicular Networks Using ML
[EN] The mmWave frequencies will be widely used in future
vehicular communications. At these frequencies, the radio
channel becomes much more vulnerable to slight changes in the
environment like motions of the device, reflections or blockage. In
high mobility vehicular communications the rapidly changing
vehicle environments and the large overheads due to frequent
beam training are the critical disadvantages in developing these
systems at mmWave frequencies. Hence, smart beam
management procedures are desired to establish and maintain the
radio channels. In this paper, we propose that using the positions
and respective velocities of the vehicles in the dynamic selection
of the beam pair, and then adapting to the changing environments
using ML algorithms, can improve both network performance
and communication stability in high mobility vehicular
communications.This work was supported by the Spanish Comision
Interministerial de Ciencia y Tecnologia (CICYT) under
projects TEC2016-78028-C3-1-P and MDM2016-O6OO,
Catalan Research Group 2017 SGR 21, and Industrial
Doctorate programme (2018-DI-084) of Generalitat de
Catalunya.Bharath-Reddy, G.; Montero, L.; Perez-Romero, J.; Molins-Benlliure, J.; Ferrando Bataller, M.; Molina, J.; Romeu, J.... (2021). Smart Beam Management for Vehicular Networks Using ML. Íñigo Cuiñas Gómez. 1-4. http://hdl.handle.net/10251/1910661
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