Relation Between Oxidant/Antioxidant Status and Postpartum Anestrous Conditions

The aim of the present study was to detect the relation between oxidant/antioxidant status and postpartum anestrous (PPA) conditions in dairy cows.The postpartum period is a very critical time that influenced mainly in cattle reproduction. A little information is obtainable in literature concerning antioxidant defense mechanisms during anestrus.The purpose of the following study is detection of the relation between oxidant/antioxidant status and postpartum anestrous (PPA) condition in dairy cows. Seventy five postpartum anestrous (PPA) and twenty five normal cyclic Holstein Friesian pluriparous dairy cows were selected on the basis of their reproductive history gained from farm records. Depend on the rectal findings and ultrasonography in addition to progesterone profile the studied animals were classified into three groups (each 25 animals) as inactive ovaries group, persistent corpus luteum group and silent heat group. Blood samples from anestrous and normal cyclic animals were gathered at day 0, day 10, day 21. These samples were utilized for detection of MDA, Vitamin C, Nitric Oxide and Total antioxidant capacity. Results of the present study revealed that MDA and Nitric Oxide were be significantly (plt0.05) higher in the groups of PPA than the normal cyclic group. Vitamin C (Ascorbic acid)nbsp levels were seen to be significantly (plt0.05) lower in normal cyclic animals in comparison to inactive ovaries group and persistent C.L group ,while there is no significant difference with the silent heat group . No statistically significant difference was detected in the total antioxidant capacity between the group of silent heat and the normal cyclic group, while the groups of persistent C.L and inactive ovaries were found to have statistically significant difference (plt0.05) with the normal cyclic group. It is concluded that supplementing diets with optimal levels of micronutrients with antioxidant capabilities is a good advice to farmers to avoid post-partum anestrum. Moreover, early approaches to conflict the progression of stress and to promote the antioxidant defense mechanisms of dairy cattle during times of increased metabolic demands appears to be Pertinent

Estudios sobre mezclas manteca de cacao/sucedáneo adecuadas para la producción de chocolate local.

Mixtures of cocoa butter with different replacers, added at different levels, were prepared. From their properties, and particularly solid fat index, helped much in selecting the more suitable mixture for local chocolate production. It was found that cocoa butter-Illexao mixtures, at levels 10% and 15% replacer, gave more satisfactory results with respect to mouthfeel, hardness and brittleness.Se prepararon mezclas de manteca de cacao con diferentes sucedáneos añadidos en diferentes proporciones. Sus propiedades y particularmente el índice de grasa sólida, ayudaron mucho en la selección de la mezcla más adecuada para la producción de chocolate local. Se encontró que las mezclas con el 10% o 15% de lllexao en manteca de cacao, dieron los resultados más satisfactorios con respecto a la palatabilidad, dureza y consistencia

The ameliorative potential of Hyphaene thebaica on streptozotocin-induced diabetic nephropathy

Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The aim of the current study is to investigate the possible beneficial effects of Hyphaene thebaica in DN. Materials and methods: For this, 50 male albino rats were divided into five groups: group I — represented the control group; group II — received Hyp­haene thebaica extracts of 150 mg/kg BW by oral gavage for 6 weeks; group III — received single intraperitoneal injections of streptozotocin (50 mg/kg BW) to induce type-2 diabetes mellitus; group IV (protective) — diabetic rats recei­ved Hyphaene thebaica extract (150 mg/kg BW) orally for 6 weeks; group V (curative) — received Hyphaene thebaica extract (150 mg/kg BW) orally after the diagnosis of DN. Results: In the DN protected group, blood glucose, urea, and creatinine decreased significantly, while insulin and C-peptide increased significantly. Moreover, cystatin C and neutrophil gelatinase-associated lipocalin decreased. Collagen fibre deposition is increased with an apparent thickening of the parietal layer of Bowman’s capsules and the basal lamina of convoluted tubules, as well as increase of the immune-reaction of caspase-3 and desmin. The introduction of Hyphaene thebaica led to greater amelioration in the biochemical markers, apoptotic alterations, and podocyte injuries of the protected group than in the curative group. Conclusions: Hyphaene thebaica may be advised as a good choice that can delay diabetic renal complications

Ácidos grasos propilenados como emulsionantes.

Hydroxy propylenyl stéarate, palmitate, laurate, oléate and linoleate were prepared by reaction of propylene oxide with fatty acid at 160 °C for five hours stirring in presence of potassium hydroxide as a catalyst. Physico-chemical properties of the five products, regarding their use as emulsifiers, were determined.Se prepararon estearato, palmitato, laurato, oleato y linoleato de hidroxipropilenilos mediante reacción de oxido de propileno con ácido graso a 160 °C durante cinco horas de agitación en presencia de hidróxido potásico como catalizador. Se determinaron las propiedades físico-químicas de los cinco productos, en cuanto a su uso como emulsionantes

Características fisicoquímicas y estabilidad oxidativa del aceite de germen de maíz egipcio producido por extracción enzimática acuosa

The physicochemical properties and the oxidative stability of Egyptian corn germ oil produced by aqueous enzymatic extraction using fungal cellulase, bacterial and bovine proteases, either individually or in combination were compared to that extracted by hexane. The optimized conditions of the new bovine protease for maximum oil yield were: 0.1% enzyme, pH 7.5 and 1h incubation time versus 0.6%, 0.63% enzyme, pH 4, 8.2 and 4, 2h incubation for fungal cellulase and bacterial protease, respectively. The higher oil yield was obtained by combining cellulase with bacterial protease (62.38%) or with bovine protease (51.94%) relative to hexane extraction (100%). The refractive index, iodine, saponification and peroxide values, DPPH scavenging activity, as well as fatty acids composition of enzymes and solvent-extracted oils were comparable. The acid value and color index of the enzyme-extracted oils were better than that produced by hexane, indicating that enzymes could be applied in the production of eco-friendly corn oil.Las propiedades fisicoquímicas y la estabilidad oxidativa del aceite de germen de maíz egipcio producido por extracción enzimática acuosa utilizando celulasas fúngicas, proteasas bacterianas y bovinas, ya sea individualmente o en combinación, se compararon con las extraídas con hexano. Las condiciones óptimas de la nueva proteasa bovina para un rendimiento máximo de aceite fueron: 0,1% enzima, pH 7.5 y tiempo de incubación 1h versus 0,6%, 0,63% enzima, pH 4; 8,2 y 4; 2h de incubación para celulasa fúngica y proteasa bacteriana, respectivamente. El mayor rendimiento de aceite se obtuvo combinando celulasa con proteasa bacteriana (62,38%) o con proteasa bovina (51,94%) en relación con la extracción de hexano (100%). El índice de refracción, yodo, saponificación y los valores de peróxido, la actividad de eliminación de DPPH, así como la composición de ácidos grasos de los aceites extraídos enzimáticamente y los extraídos con disolventes fueron comparables. El índice de acidez y el índice de color de los aceites extraídos con enzimas fueron mejores que los obtenidos con el hexano, lo que indica que las enzimas podrían aplicarse en la producción de aceite de maíz ecológico

Powder Bed Layer Characteristics: The Overseen First-Order Process Input

A discrete element powder model is used in conjunction with a finite volume melting model on the first layer of a powder bed selective laser melting process

From Profile to Surface Monitoring: SPC for Cylindrical Surfaces Via Gaussian Processes

Quality of machined products is often related to the shapes of surfaces that are constrained by geometric tolerances. In this case, statistical quality monitoring should be used to quickly detect unwanted deviations from the nominal pattern. The majority of the literature has focused on statistical profile monitoring, while there is little research on surface monitoring. This paper faces the challenging task of moving from profile to surface monitoring. To this aim, different parametric approaches and control-charting procedures are presented and compared with reference to a real case study dealing with cylindrical surfaces obtained by lathe turning. In particular, a novel method presented in this paper consists of modeling the manufactured surface via Gaussian processes models and monitoring the deviations of the actual surface from the target pattern estimated in phase I. Regardless of the specific case study in this paper, the proposed approach is general and can be extended to deal with different kinds of surfaces or profiles

Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry

© 2020 World Stroke Organization.[Background]: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. [Aim]: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. [Methods]: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020–16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). [Results]: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970–1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920–1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130–280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4–60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63–15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07–2.94, p ¼ 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34–0.98, p ¼ 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19. [Conclusions]: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes

Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics