European Community Multi-Center Trial "Fetal ECG Analysis During Labor": ST plus CTG analysis

This report form part of the European Community Multi-Center Trial "Fetal ECG Analysis during Labor". Aim of this prospective trial was to identify changes in the fetal ECG waveform with cases of verified fetal hypoxia. In this paper we also report on the use of a newly developed automatic system for identification of ST waveform changes (ST Log). All ECG were recorded with the STAN recorder (Neoventa Medical AB, Gothenburg, Sweden). The ECG information was not displayed during labor in order not to influence the clinical management. This report includes data from 320 cases and include six cases of fetal intrapartum hypoxia. Twenty seven cases showed changes in ST waveform. All five cases with the most marked ST change (a rise in T/QRS of >0.10 units and lasting more then 10 minutes) had signs of ongoing intrapartum hypoxia. Six out of six cases with evidence of intrapartum asphyxia, showed ST changes. On the basis of our multi-center trial it appears that the combined analysis of CTG and ST waveform changes provides an accurate way to identify adverse events during labor. The work is continuing with a new STAN recorder developed by Neoventa Medical in Goteborg and currently being tested in a Swedish randomized, controlled multi-center trial

Potential application of serological tests on fluids from carcasses: detection of antibodies against Toxoplasma gondii and Sarcoptes scabiei in red foxes (Vulpes vulpes)

<p>Abstract</p> <p>Background</p> <p>Serological surveys for disease investigation of wild animal populations require obtaining blood samples for analysis, which has logistic, ethic and economic difficulties. Applying serological test to fluids collected from dead animals is an alternative. The aim of this study was to assess if antibodies could be detected in two types of fluids collected from 56 carcasses of red foxes (<it>Vulpes vulpes</it>): pleural fluid and lung extract.</p> <p>Findings</p> <p>In 22 (39%) foxes antibodies against <it>Sarcoptes scabiei </it>were detected in both fluid types by ELISA and Western blot. In 46 (82%) foxes, antibodies against <it>Toxoplasma gondii </it>were detected in pleural fluid and in 41 (73%) in lung extract applying a Toxo-screen test (DAT). Antibodies were still detectable in the same fluids kept at room temperature for 28 days, although in fewer foxes (16 and 14 foxes tested for <it>T. gondii </it>in lung extract and pleural fluid respectively; and 1 and 4 tested for <it>S. scabiei </it>in lung extract and pleural fluid respectively.</p> <p>Conclusions</p> <p>These results indicate the potential utility of using fluids from carcasses for antibody screening of wild animals at the population level.</p

Supernovae data and perturbative deviation from homogeneity

We show that a spherically symmetric perturbation of a dust dominated $\Omega=1$ FRW universe in the Newtonian gauge can lead to an apparent acceleration of standard candles and provide a fit to the magnitude-redshift relation inferred from the supernovae data, while the perturbation in the gravitational potential remains small at all scales. We also demonstrate that the supernovae data does not necessarily imply the presence of some additional non-perturbative contribution by showing that any Lemaitre-Tolman-Bondi model fitting the supernovae data (with appropriate initial conditions) will be equivalent to a perturbed FRW spacetime along the past light cone.Comment: 8 pages, 3 figures; v2: 1 figure added, references added/updated, minor modifications and clarifications, matches published versio

Back-reaction and effective acceleration in generic LTB dust models

We provide a thorough examination of the conditions for the existence of back-reaction and an "effective" acceleration (in the context of Buchert's averaging formalism) in regular generic spherically symmetric Lemaitre-Tolman-Bondi (LTB) dust models. By considering arbitrary spherical comoving domains, we verify rigorously the fulfillment of these conditions expressed in terms of suitable scalar variables that are evaluated at the boundary of every domain. Effective deceleration necessarily occurs in all domains in: (a) the asymptotic radial range of models converging to a FLRW background, (b) the asymptotic time range of non-vacuum hyperbolic models, (c) LTB self-similar solutions and (d) near a simultaneous big bang. Accelerating domains are proven to exist in the following scenarios: (i) central vacuum regions, (ii) central (non-vacuum) density voids, (iii) the intermediate radial range of models converging to a FLRW background, (iv) the asymptotic radial range of models converging to a Minkowski vacuum and (v) domains near and/or intersecting a non-simultaneous big bang. All these scenarios occur in hyperbolic models with negative averaged and local spatial curvature, though scenarios (iv) and (v) are also possible in low density regions of a class of elliptic models in which local spatial curvature is negative but its average is positive. Rough numerical estimates between -0.003 and -0.5 were found for the effective deceleration parameter. While the existence of accelerating domains cannot be ruled out in models converging to an Einstein de Sitter background and in domains undergoing gravitational collapse, the conditions for this are very restrictive. The results obtained may provide important theoretical clues on the effects of back-reaction and averaging in more general non-spherical models.Comment: Final version accepted for publication in Classical and Quantum Gravity. 47 pages in IOP LaTeX macros, 12 pdf figure

The Herschel exploitation of local galaxy Andromeda (HELGA) V: Strengthening the case for substantial interstellar grain growth

In this paper we consider the implications of the distributions of dust and metals in the disc of M31. We derive mean radial dust distributions using a dust map created from Herschel images of M31 sampling the entire far-infrared (FIR) peak. Modified blackbodies are fit to approximately 4000 pixels with a varying, as well as a fixed, dust emissivity index (beta). An overall metal distribution is also derived using data collected from the literature. We use a simple analytical model of the evolution of the dust in a galaxy with dust contributed by stellar sources and interstellar grain growth, and fit this model to the radial dust-to-metals distribution across the galaxy. Our analysis shows that the dust-to-gas gradient in M31 is steeper than the metallicity gradient, suggesting interstellar dust growth is (or has been) important in M31. We argue that M31 helps build a case for cosmic dust in galaxies being the result of substantial interstellar grain growth, while the net dust production from stars may be limited. We note, however, that the efficiency of dust production in stars, e.g., in supernovae (SNe) ejecta and/or stellar atmospheres, and grain destruction in the interstellar medium (ISM) may be degenerate in our simple model. We can conclude that interstellar grain growth by accretion is likely at least as important as stellar dust production channels in building the cosmic dust component in M31.Comment: 12 pages, 7 figures. Published in MNRAS 444, 797. This version is updated to match the published versio

Higher order finite difference schemes for the magnetic induction equations

We describe high order accurate and stable finite difference schemes for the initial-boundary value problem associated with the magnetic induction equations. These equations model the evolution of a magnetic field due to a given velocity field. The finite difference schemes are based on Summation by Parts (SBP) operators for spatial derivatives and a Simultaneous Approximation Term (SAT) technique for imposing boundary conditions. We present various numerical experiments that demonstrate both the stability as well as high order of accuracy of the schemes.Comment: 20 page

Aging phenomena in spin glasses: theory, experiment, and simulation

We study numerically temperature-shift and field-shift aging protocols on the 3-dimensional (3D) Ising Edwards-Anderson (EA) spin-glass (SG) model focusing on respectively the temperature-chaos nature and the stability under a static field of the SG phase. The results of the latter strongly support the droplet theory which predicts the instability of the SG phase under the field. They are also discussed in relation with the experimental studies.Comment: 6 pages, 5 figures, submitted to ICM200

Hubble flow variance and the cosmic rest frame

We characterize the radial and angular variance of the Hubble flow in the COMPOSITE sample of 4534 galaxies, on scales in which much of the flow is in the nonlinear regime. With no cosmological assumptions other than the existence of a suitably averaged linear Hubble law, we find with decisive Bayesian evidence (ln B >> 5) that the Hubble constant averaged in independent spherical radial shells is closer to its asymptotic value when referred to the rest frame of the Local Group, rather than the standard rest frame of the Cosmic Microwave Background. An exception occurs for radial shells in the range 40/h-60/h Mpc. Angular averages reveal a dipole structure in the Hubble flow, whose amplitude changes markedly over the range 32/h-62/h Mpc. Whereas the LG frame dipole is initially constant and then decreases significantly, the CMB frame dipole initially decreases but then increases. The map of angular Hubble flow variation in the LG rest frame is found to coincide with that of the residual CMB temperature dipole, with correlation coefficient -0.92. These results are difficult to reconcile with the standard kinematic interpretation of the motion of the Local Group in response to the clustering dipole, but are consistent with a foreground non-kinematic anisotropy in the distance-redshift relation of 0.5% on scales up to 65/h Mpc. Effectively, the differential expansion of space produced by nearby nonlinear structures of local voids and denser walls and filaments cannot be reduced to a local boost. This hypothesis suggests a reinterpretation of bulk flows, which may potentially impact on calibration of supernovae distances, anomalies associated with large angles in the CMB anisotropy spectrum, and the dark flow inferred from the kinematic Sunyaev-Zel'dovich effect. It is consistent with recent studies that find evidence for a non-kinematic dipole in the distribution of distant radio sources.Comment: 37 pages, 9 tables, 13 figures; v2 adds extensive new analysis (including additional subsections, tables, figures); v3 adds a Monte Carlo analysis (with additional table, figure) which further tightens the statistical robustness of the dipole results; v4 adds further clarifications, small corrections, references and discussion of Planck satellite results; v5 typos fixed, matches published versio