О подходе к созданию цифровой модели рельефа дна Арктического бассейна

In the report an approach to developing technology to create digital elevation models of the seabed using heterogeneous data is considered. The technology was tested on material hydrographic work carried out by domestic and foreign researchers in the Central Arctic Ocean with drifting ice, surface ships and submarines. The necessity of systematic analysis of different quality bathymetric information varying by level of reliability when creating common databases and digital models is justified.Описывается подход к разработке технологии создания цифровых моделей рельефа морского дна с использованием данных разнородных съемок. Технология апробирована на материалах гидрографических работ, выполненных отечественными и зарубежными исследователями в центральной части Северного Ледовитого океана с дрейфующего льда, с надводных и подводных носителей. Обоснована необходимость систематического анализа качества неравноточной батиметрической информации, полученной при маршрутных и площадных съемках и различающейся по уровню достоверности, при создании единых баз данных и цифровых моделей

Functional Single-Chain Polymer Nanoparticles : Targeting and Imaging Pancreatic Tumors in Vivo

The development of tools for the early diagnosis of pancreatic adenocarcinoma is an urgent need in order to increase treatment success rate and reduce patient mortality. Here, we present a modular nanosystem platform integrating soft nanoparticles with a targeting peptide and an active imaging agent for diagnostics. Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer. The gamma emitter 67Ga was incorporated by chelation and allowed in vivo investigation of the pharmacokinetic properties of the nanoparticles using single photon emission computerized tomography (SPECT). The resulting engineered nanosystem was tested in a xenograph mouse model of human pancreatic adenocarcinoma. Imaging results demonstrate that accumulation of targeted SCPNs in the tumor is higher than that observed for nontargeted nanoparticles due to improved retention in this tissue

Functional Single-Chain Polymer Nanoparticles: Targeting and Imaging Pancreatic Tumors in Vivo

The development of tools for the early diagnosis of pancreatic adenocarcinoma is an urgent need in order to increase treatment success rate and reduce patient mortality. Here, we present a modular nanosystem platform integrating soft nanoparticles with a targeting peptide and an active imaging agent for diagnostics. Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer. The gamma emitter 67Ga was incorporated by chelation and allowed in vivo investigation of the pharmacokinetic properties of the nanoparticles using single photon emission computerized tomography (SPECT). The resulting engineered nanosystem was tested in a xenograph mouse model of human pancreatic adenocarcinoma. Imaging results demonstrate that accumulation of targeted SCPNs in the tumor is higher than that observed for nontargeted nanoparticles due to improved retention in this tissue. ¸ 2016 American Chemical Society