Estrategia did?ctica para el fortalecimiento del pensamiento matem?tico del grado 1? del colegio "San Sim?n" sede Montealegre jornada ma?ana Ibague - Tolima

111 p. Recurso Electr?nicoEl presente proyecto pretende fomentar participativamente el pensamiento matem?tico por medio de actividades l?dicas e innovadoras en estudiantes del grado 1? del colegio ?San Sim?n?. Por este hecho, se quiere dejar establecido un camino de apoyo a futuros docentes para transformar las competencias matem?ticas con un soporte fijado a partir del juego. Para los antecedentes, se tuvieron en cuenta algunas investigaciones y tesis realizadas en M?xico y Colombia de acuerdo a la problem?tica vista desde diferentes contextos educativos que llevan como punto central la ense?anza-aprendizaje en las matem?ticas de primaria. As? mismo, se retroaliment? significativamente con te?ricos contempor?neos para conocer, indagar y ampliar otros trabajos investigativos. Adicionalmente, este proyecto est? basado en el modelo de investigaci?n-acci?n en el aula con enfoque cualitativo; la poblaci?n objeto de estudio son aproximadamente 42 estudiantes, cuatro docentes de la instituci?n donde se llev? a cabo e trabajo investigativo y un docente de la Universidad del Tolima a los cuales se les aplic? instrumentos de dicho enfoque como lo son: gu?a de observaci?n, pre-test, ficha de redacci?n, unidad did?ctica y pos-test. Para el an?lisis de la informaci?n se realizar? un cruce de informaci?n recolectada (contraste), espec?ficamente de los grupos focales de estudiantes y profesores con el fin de obtener informaci?n concreta del problema de investigaci?n. Los datos obtenidos ser?n analizados con la finalidad de crear categor?as y subcategor?as para, despu?s redactar el informe final detallado. Los resultados que se esperan con este proyecto investigativo son, en primera instancia despertar el inter?s a los estudiantes por las matem?ticas usando actividades l?dicas e innovadoras dentro y fuera del aula y en segundo lugar dejar establecido un camino de apoyo a futuros docentes para transformar la visi?n de la ense?anza-aprendizaje de las matem?ticas en primaria.This project aims to encourage participatory mathematical thinking through playful and innovative activities in 1st grade students of the school "San Simon". Because of this, you want to leave in place a way to support future teachers to transform math skills with a bracket from the game. For background, some research and thesis made in Mexico and Colombia, according to the problems seen from different educational contexts that take as a central point of teaching and learning in primary mathematics were considered. He also fed back significantly to contemporary to know, explore and expand other theoretical research work. Additionally, this project is based on the model of action research in the classroom with a qualitative approach; the study population are about 42 students, four teachers from the institution where he was held and research work and teaching at the University of Tolima to which we applied instruments of this approach as they are: observation guide, pre -test, record of writing, teaching unit and post-test. For the analysis of the information collected a cross information (contrast) will be held, specifically in the focus groups of students and teachers in order to obtain specific information research problem. The data obtained will be analyzed in order to create categories and subcategories to then draft the detailed final report. The results are expected with this research project are, firstly arouse interest students in mathematics using playful and innovative activities within and outside the classroom and secondly let established a way to support future teachers to transform the vision the teaching and learning of mathematics in primary school. Keywords: encouraging, teaching and learning, class, fun, math, teaching strategy

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study

Exposures constitute a dense network of the environment: exposome. Here, we argue for embracing the exposome paradigm to investigate the sum of nongenetic "risk" and show how predictive modeling approaches can be used to construct an exposome score (ES; an aggregated score of exposures) for schizophrenia. The training dataset consisted of patients with schizophrenia and controls, whereas the independent validation dataset consisted of patients, their unaffected siblings, and controls. Binary exposures were cannabis use, hearing impairment, winter birth, bullying, and emotional, physical, and sexual abuse along with physical and emotional neglect. We applied logistic regression (LR), Gaussian Naive Bayes (GNB), the least absolute shrinkage and selection operator (LASSO), and Ridge penalized classification models to the training dataset. ESs, the sum of weighted exposures based on coefficients from each model, were calculated in the validation dataset. In addition, we estimated ES based on meta-analyses and a simple sum score of exposures. Accuracy, sensitivity, specificity, area under the receiver operating characteristic, and Nagelkerke's R2 were compared. The ESMeta-analyses performed the worst, whereas the sum score and the ESGNB were worse than the ESLR that performed similar to the ESLASSO and ESRIDGE. The ESLR distinguished patients from controls (odds ratio [OR] = 1.94, P < .001), patients from siblings (OR = 1.58, P < .001), and siblings from controls (OR = 1.21, P = .001). An increase in ESLR was associated with a gradient increase of schizophrenia risk. In reference to the remaining fractions, the ESLR at top 30%, 20%, and 10% of the control distribution yielded ORs of 3.72, 3.74, and 4.77, respectively. Our findings demonstrate that predictive modeling approaches can be harnessed to evaluate the exposome