The endocrine function of osteocalcin regulated by bone resorption. a lesson from reduced and increased bone mass diseases

Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the decarboxylation of osteocalcin and to control glucose metabolism, male fertility, and cognitive functions was demonstrated by the use of animal models. In this review we described how diseases characterized by defective and increased bone resorption activity, as osteopetrosis and osteoporosis, were essential to understand the involvement of bone tissue in whole body physiology. To translate this knowledge into humans, recently published reports on patients were described, but further studies should be performed to confirm this complex hormonal regulation in humans

Evidence for a spectroscopic direct detection of reflected light from 51 Peg b

The detection of reflected light from an exoplanet is a difficult technical challenge at optical wavelengths. Even though this signal is expected to replicate the stellar signal, not only is it several orders of magnitude fainter, but it is also hidden among the stellar noise. We apply a variant of the cross-correlation technique to HARPS observations of 51 Peg to detect the reflected signal from planet 51 Peg b. Our method makes use of the cross-correlation function of a binary mask with high-resolution spectra to amplify the minute planetary signal that is present in the spectra by a factor proportional to the number of spectral lines when performing the cross correlation. The resulting cross-correlation functions are then normalized by a stellar template to remove the stellar signal. Carefully selected sections of the resulting normalized CCFs are stacked to increase the planetary signal further. The recovered signal allows probing several of the planetary properties, including its real mass and albedo. We detect evidence for the reflected signal from planet 51 Peg b at a significance of 3\sigma_noise. The detection of the signal permits us to infer a real mass of 0.46^+0.06_-0.01 M_Jup (assuming a stellar mass of 1.04\;M_Sun) for the planet and an orbital inclination of 80^+10_-19 degrees. The analysis of the data also allows us to infer a tentative value for the (radius-dependent) geometric albedo of the planet. The results suggest that 51Peg b may be an inflated hot Jupiter with a high albedo (e.g., an albedo of 0.5 yields a radius of 1.9 \pm 0.3 R_Jup for a signal amplitude of 6.0\pm0.4 x 10^-5). We confirm that the method we perfected can be used to retrieve an exoplanet's reflected signal, even with current observing facilities. The advent of next generation of observing facilities will yield new opportunities for this type of technique to probe deeper into exoplanets.Comment: 9 pages, 6 figure

The HARPS search for southern extra-solar planets. XXVII. Up to seven planets orbiting HD 10180: probing the architecture of low-mass planetary systems

Context. Low-mass extrasolar planets are presently being discovered at an increased pace by radial velocity and transit surveys, opening a new window on planetary systems. Aims. We are conducting a high-precision radial velocity survey with the HARPS spectrograph which aims at characterizing the population of ice giants and super-Earths around nearby solar-type stars. This will lead to a better understanding of their formation and evolution, and yield a global picture of planetary systems from gas giants down to telluric planets. Methods. Progress has been possible in this field thanks in particular to the sub-m/s radial velocity precision achieved by HARPS. We present here new high-quality measurements from this instrument. Results. We report the discovery of a planetary system comprising at least five Neptune-like planets with minimum masses ranging from 12 to 25 M_Earth, orbiting the solar-type star HD 10180 at separations between 0.06 and 1.4 AU. A sixth radial velocity signal is present at a longer period, probably due to a 65-M_Earth object. Moreover, another body with a minimum mass as low as 1.4 M_Earth may be present at 0.02 AU from the star. This is the most populated exoplanetary system known to date. The planets are in a dense but still well-separated configuration, with significant secular interactions. Some of the orbital period ratios are fairly close to integer or half-integer values, but the system does not exhibit any mean-motion resonances. General relativity effects and tidal dissipation play an important role to stabilize the innermost planet and the system as a whole. Numerical integrations show long-term dynamical stability provided true masses are within a factor ~3 from minimum masses. We further note that several low-mass planetary systems exhibit a rather "packed" orbital architecture with little or no space left for additional planets. (Abridged)Comment: 20 pages, 15 figures, accepted for publication in A&

The HARPS search for southern extra-solar planets I. HD330075 b: a new 'hot Jupiter'

We report on the first extra-solar planet discovered with the brand new HARPS instrument. The planet is a typical 'hot Jupiter' with m2sini = 0.62 MJup and an orbital period of 3.39 days, but from the photometric follow-up of its parent star HD330075 we can exclude the presence of a transit. The induced radial-velocity variations exceed 100 m/s in semi-amplitude and are easily detected by state-of-the-art spectro-velocimeters. Nevertheless, the faint magnitude of the parent star (V = 9.36) benefits from the efficient instrument: With HARPS less than 10 observing nights and 3 hours of total integration time were needed to discover the planet and characterize its orbit. The orbital parameters determined from the observations made during the first HARPS run in July 2003 have been confirmed by 7 additional observations carried out in February 2004. The bisector analysis and a photometric follow-up give no hint for activity-induced radial-velocity variations, indicating that the velocity curve is best explained by the presence of a low-mass companion to the star. In this paper we present a set of 21 measurements of excellent quality with weighted rms as low as 2.0 m/s. These measurements lead to a well defined orbit and consequently to the precise orbital parameters determination of the extra-solar planet HD330075b.Comment: 5 pages, 2 figures, accepted for publication by Astronomy and Astrophysics, see also http://obswww.unige.ch/~udry/planet/planet.htm

On the Ambiguity of Spontaneously Broken Gauge Symmetry

Local gauge symmetries cannot break spontaneously, according to Elitzur's theorem, but this leaves open the possibility of breaking some global subgroup of the local gauge symmetry, which is typically the gauge symmetry remaining after certain (e.g. Coulomb or Landau) gauge choices. We show that in an SU(2) gauge-Higgs system such symmetries do indeed break spontaneously, but the location of the breaking in the phase diagram depends on the choice of global subgroup. The implication is that there is no unique broken gauge symmetry, but rather many symmetries which break in different places. The problem is to decide which, if any, of these gauge symmetry breakings is associated with a transition between physically different, confining and non-confining phases. Several proposals - Kugo-Ojima, Coulomb, and monopole condensate - are discussed.Comment: 9 pages, 6 figures. v2: references adde

Quantitative Analysis of Bloggers Collective Behavior Powered by Emotions

Large-scale data resulting from users online interactions provide the ultimate source of information to study emergent social phenomena on the Web. From individual actions of users to observable collective behaviors, different mechanisms involving emotions expressed in the posted text play a role. Here we combine approaches of statistical physics with machine-learning methods of text analysis to study emergence of the emotional behavior among Web users. Mapping the high-resolution data from digg.com onto bipartite network of users and their comments onto posted stories, we identify user communities centered around certain popular posts and determine emotional contents of the related comments by the emotion-classifier developed for this type of texts. Applied over different time periods, this framework reveals strong correlations between the excess of negative emotions and the evolution of communities. We observe avalanches of emotional comments exhibiting significant self-organized critical behavior and temporal correlations. To explore robustness of these critical states, we design a network automaton model on realistic network connections and several control parameters, which can be inferred from the dataset. Dissemination of emotions by a small fraction of very active users appears to critically tune the collective states

The HARPS search for southern extra-solar planets. XXIV. Companions to HD 85390, HD 90156 and HD 103197: A Neptune analogue and two intermediate mass planets

We report the detection of three new extrasolar planets orbiting the solar type stars HD 85390, HD 90156 and HD 103197 with the HARPS spectrograph mounted on the ESO 3.6-m telescope at La Silla observatory. HD 85390 has a planetary companion with a projected intermediate mass (42.0 Earth masses) on a 788-day orbit (a=1.52 AU) with an eccentricity of 0.41, for which there is no analogue in the solar system. A drift in the data indicates the presence of another companion on a long period orbit, which is however not covered by our measurements. HD 90156 is orbited by a warm Neptune analogue with a minimum mass of 17.98 Earth masses (1.05 Neptune masses), a period of 49.8 days (a=0.25 AU) and an eccentricity of 0.31. HD 103197 has an intermediate mass planet on a circular orbit (P=47.8 d, Msini=31.2 Earth masses). We discuss the formation of planets of intermediate mass (about 30-100 Earth masses) which should be rare inside a few AU according to core accretion formation models.Comment: 9 pages, 5 figures. Accepted to A&

Precursors of extreme increments

We investigate precursors and predictability of extreme increments in a time series. The events we are focusing on consist in large increments within successive time steps. We are especially interested in understanding how the quality of the predictions depends on the strategy to choose precursors, on the size of the event and on the correlation strength. We study the prediction of extreme increments analytically in an AR(1) process, and numerically in wind speed recordings and long-range correlated ARMA data. We evaluate the success of predictions via receiver operator characteristics (ROC-curves). Furthermore, we observe an increase of the quality of predictions with increasing event size and with decreasing correlation in all examples. Both effects can be understood by using the likelihood ratio as a summary index for smooth ROC-curves