Analysis Of Single Server Queueing System With Batch Service Under Multiple Vacations With Loss And Feedback

Consider a single server queueing system with foxed batch service under multiple vacations with loss and feedback in which the arrival rate ? follows a Poisson process and the service time follows an exponential distribution with parameter ?. Assume that the system initially contain k customers when the server enters the system and starts the service in batch. The concept of feedback is incorporated in this model (i.e) after completion of the service, if this batch of customers dissatisfied then this batch may join the queue with probability q and with probability (1-q) leaves the system. This q is called a feedback probability. After completion of the service if he finds more than k customers in the queue then the first k customers will be taken for service and service will be given as a batch of size k and if he finds less than k customers in the queue then he leaves for a multiple vacation of exponential length ?. The impatient behaviour of customer is also studied in this model (i.e) the arriving customer may join the queue with probability p when the server is busy or in vacation. This probability p is called loss probability. This model is completely solved by constructing the generating function and Rouche’s theorem is applied and we have derived the closed form solutions for probability of number of customers in the queue during the server busy and in vacation. Further we are providing the analytical solution for mean number of customers and variance of the system. Numerical studies have been done for analysis of mean and variance for various values of ?, µ, ?, p, q and k and also various particular cases of this model have been discussed. Keywords : Single Server , Batch Service, Loss and Feedback,  Multiple vacations, Steady state distribution

Analysis of Single Server Fixed Batch Service Queueing System under Multiple Vacation with Catastrophe

Consider a single server fixed batch service queueing system under multiple vacation with a possibility of catastrophe in which the arrival rate ? follows a Poisson process and the service time follows an exponential distribution with parameter ?. Further we assume that the catastrophe occur at the rate of ? which follows a Poisson process and the length of time the server in vacation follows an exponential distribution with parameter ?.  Assume that the system initially contains k customers when the server enters in to the system and starts the service immediately in a batch of size k. After completion of a service, if he finds less than k customers in the queue, then the server goes for a multiple vacation of length ?. If there are more than k customers in the queue then the first k customers will be selected from the queue and service will be given as a batch. We are analyzing the possibility of catastrophe that is whenever a catastrophe occurs in the system, all the customers who are in the system will be completely destroyed and system becomes an empty and server goes for a multiple vacation. This model is completely solved by constructing the generating function  and we have derived the closed form solutions for probability of number of customers in the queue during the server busy and in vacation. Further we are providing the analytical solution for mean number of customers and variance of the system. Numerical studies have been done for analysis of mean and variance of number of customers in the system for various values of ?, µ, ? and k and also various particular cases of this model have been discussed. Keywords: Single server queue , Fixed batch service , Catastrophe, Multiple vacation, Steady state distributio

Ayurveda and Communicable Diseases

Indian medical heritage flows in two distinctive but mutually complimenting streams. The oral tradition being followed by millions of housewives and thousands of local health practitioners is the practical aspect of codified streams such as Ayurveda, Siddha, Unani. These oral traditions are head based and take care of the basic health needs of the people using immediately available local resources. Majority of these are plant based remedies, supplemented by animal and mineral products. Many of the practices followed by these local streams can be understood and evaluated by the codified stream such as Ayurveda. These streams are not static, historical scrutiny of their evolution shows the enriching phenomena at all times. Thus we have more than 7000 species of higher and lower plants and hundreds of minerals and animal product used in local health tradition to manage hundreds of disease conditions. A pertinent question that arises here is that in which basis these systems got enriched. Is it just trial error method over a point of time which gave rise to this rich tradition, is it an intuitive knowledge born out of close association with nature. One of the reasons for this attitude can be, that one is always made to believe that the science means that which can be explained by western models of logic and epistemology. The world view being developed and adopted by the dominant western scientific paradigm never fits in to the world view being followed and practiced by the indigenous traditions. This is well accepted by us due to the last 200 yrs of political and cultural domination by western and other alien forces

Influence of anti-epileptic drugs on hematological and biochemical parameters in patients with epilepsy

Background: Epilepsy is a chronic neurological condition which may require long-term treatment with antiepileptic drugs (AEDs). The challenge in AED management is to attain freedom from seizures, without side-effects and with good quality-of-life. However, AEDs are reported to induce potential adverse effects, which can remain unnoticed over long time. In this regard, earlier studies report inconsistent results in hematological and biochemical toxicity of AEDs. The objective of the present study was to evaluate the effects of AED monotherapy and polytherapy on hematological and biochemical parameters.Methods: This was a cross-sectional, observational study carried out among patients with epilepsy (PWE) receiving AEDs. The data on baseline demographic characteristics, treatment, adverse drug reactions, hematological, and biochemical investigations were collected. Statistical analysis was performed using the SPSS version 18 and descriptive statistics such as mean and median were used to summarize the data and inferential tests like Chi-square was used to compare categorical variables between groups.Results: There were 255 PWE in mean age range of 28.68±9.29 years, with 56.54% males. A total of 78.04% had focal, 18.04% had generalized seizures and remaining 3.92% were unclassified. Majority of (55.69%) PWE received polytherapy with AEDs. Females had significantly lower levels of hemoglobin (Hb) when compared with males (p=0.000), and patients on AED polytherapy showed significant difference in low Hb (p=0.006) and high alkaline phosphatase (ALP) levels (p=0.001).Conclusions: The results of this study showed significant alterations in the levels of Hb and ALP with the use of AED polytherapy in PWE. Routine hematological and biochemical investigations may be considered during AED treatment in those patients receiving AED polytherapy

Life support systems analysis and technical trades for a lunar outpost

The NASA/JPL life support systems analysis (LISSA) software tool was used to perform life support system analysis and technology trades for a Lunar Outpost. The life support system was modeled using a chemical process simulation program on a steady-state, one-person, daily basis. Inputs to the LiSSA model include metabolic balance load data, hygiene load data, technology selection, process operational assumptions and mission parameter assumptions. A baseline set of technologies has been used against which comparisons have been made by running twenty-two cases with technology substitutions. System, subsystem, and technology weights and powers are compared for a crew of 4 and missions of 90 and 600 days. By assigning a weight value to power, equivalent system weights are compared. Several less-developed technologies show potential advantages over the baseline. Solid waste treatment technologies show weight and power disadvantages but one could have benefits associated with the reduction of hazardous wastes and very long missions. Technology development towards reducing the weight of resupplies and lighter materials of construction was recommended. It was also recommended that as technologies are funded for development, contractors should be required to generate and report data useful for quantitative technology comparisons

Natural history and clinical effect of aortic valve regurgitation after left ventricular assist device implantation

ObjectivesAortic valve regurgitation reduces left ventricular assist device mechanical efficiency. Evidence has also suggested that left ventricular assist device implantation can induce or exacerbate aortic valve regurgitation. However, this has not been compared with aortic valve regurgitation progression in a nonsurgical end-stage heart failure population. Furthermore, its clinical effect is unclear. We sought to characterize the development and progression of aortic valve regurgitation in left ventricular assist device recipients and to identify its clinical effect.MethodsA review of all consecutive patients who received an intracorporeal left ventricular assist device at Duke University Medical Center from January 2004 to January 2011 was conducted. Cases of previous or concomitant aortic valve surgery were excluded. Data from the remaining implants (n = 184) and a control group of contemporaneous nonsurgical patients with end-stage heart failure (n = 132) were analyzed. Serial transthoracic echocardiography was used to characterize aortic valve regurgitation as a function of time.ResultsLeft ventricular assist device implantation was associated with worsening aortic valve regurgitation, defined as an increase in aortic valve regurgitation grade, relative to the nonsurgical patients with end-stage heart failure (P < .0001). The recipients of continuous flow left ventricular assist devices were more likely than recipients of pulsatile left ventricular assist devices to develop worsening aortic valve regurgitation (P = .0348). Moderate or severe aortic valve regurgitation developed in 21 left ventricular assist device recipients; this was unrelated to the type of device implanted (continuous vs pulsatile; P = .754) or aortic valve regurgitation grade before left ventricular assist device implantation (P = .42). Five patients developed severe aortic valve regurgitation; all of whom underwent aortic valve procedures.ConclusionsNative aortic valve regurgitation developed and/or progressed after left ventricular assist device implantation, with this effect being more pronounced in continuous flow left ventricular assist device recipients. However, the preoperative aortic valve regurgitation grade failed to correlate with the development of substantial aortic valve regurgitation after left ventricular assist device implantation. After left ventricular assist device implantation, aortic valve regurgitation had a small, but discernible, clinical effect, with some patients developing severe aortic valve regurgitation and requiring aortic valve procedures. These data have implications for the long-term management of left ventricular assist device recipients, in particular as the durability of implantable continuous flow left ventricular assist device therapy improves

Transgenic Acacia sinuata from Agrobacterium tumefaciens-mediated transformation of hypocotyls

Transgenic herbicide tolerant Acacia sinuata plants were produced by transformation with the bar gene conferring phosphinothricin resistance. Precultured hypocotyl explants were infected with Agrobacterium tumefaciens strain EHA105 in the presence of 100 mu M acetosyringone and shoots regenerated on MS (Murashige and Skoog, 1962, Physiol Plant 15:473-497) medium with 13.3 mu M benzylaminopurine, 2.6 mu M indole-3-acetic acid, 1 g l(-1) activated charcoal, 1.5 mg l(-1) phosphinothricin, and 300 mg l(-1) cefotaxime. Phosphinothricin at 1.5 mg l(-1) was used for the selection. Shoots surviving selection on medium with phosphinothricin expressed GUS. Following Southern hybridization, eight independent shoots regenerated of 500 cocultivated explants were demonstrated to be transgenic, which represented transformation frequency of 1.6%. The transgenics carried one to four copies of the transgene. Transgenic shoots were propagated as microcuttings in MS medium with 6.6 mu M 6-benzylaminopurine and 1.5 mg l(-1) phosphinothricin. Shoots elongated and rooted in MS medium with gibberellic acid and indole-3-butyric acid, respectively both supplemented with 1.5 mg l(-1) phosphinothricin. Micropropagation of transgenic plants by microcuttings proved to be a simple means to bulk up the material. Several transgenic plants were found to be resistant to leaf painting with the herbicide Basta

Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein kinase (CK) Iδ and/or CKIɛ, but not by CKII. The CKI inhibitors, CKI-7 and IC261, reduced Ser-1106 phosphorylation and decreased formation of etoposide-stabilized topo II–DNA cleavable complex. In contrast, the CKII inhibitor, 5,6-dichlorobenzimidazole riboside, did not affect etoposide-stabilized topo II–DNA cleavable complex formation. Since, IC261 specifically targets the Ca2+-regulated isozymes, CKIδ and CKIɛ, we examined the effect of down-regulating these enzymes on Ser-1106 phosphorylation. Down-regulation of these isozymes with targeted si-RNAs led to hypophosphorylation of the Ser-1106 containing peptide. However, si-RNA-mediated down-regulation of CKIIα and α′ did not alter Ser-1106 phosphorylation. Furthermore, reduced phosphorylation of Ser-1106, observed in HRR25 (CKIδ/ɛ homologous gene)-deleted Saccharomyces cerevisiae cells transformed with human topo IIα, was enhanced following expression of human CKIɛ. Down-regulation of CKIδ and CKIɛ also led to reduced formation of etoposide stabilized topo II–DNA cleavable complex. These results provide strong support for an essential role of CKIδ/ɛ in phosphorylating Ser-1106 in human topo IIα and in regulating enzyme function

Characterization of Post-Rainy Season Grown Indigenous and Exotic Germplasm Lines of Sorghum for Morphological and Yield Traits

Sorghum is a major staple crop and vital for the marginal farmers in Asian and African countries. Landraces or germplasm lines adapted to biotic and abiotic stresses are the prime source of adaptive traits in the crop breeding programs. In order to assess the genetic variability, 141 exotic germplasm lines and 36 popular varieties were evaluated for eight agro-morphological traits. Wide range of values were observed for grain yield (6.6–124.4 g/plant), seed index (1.5–7.1 g/100 seeds), panicle length (8–44 cm) and panicle width (7.25 cm). High genotypic and phenotypic coefficient of variation was observed for grain yield per plant. The values of broad sense heritability in the sorghum core population ranged from 0.75 to 0.99. Seed weight, days to flowering, panicle width and leaf area were significantly correlated with grain yield (P ≤ 0.01). Seed weight was positively correlated with panicle width (correlation coefficient 0.31), while negatively correlated with panicle length (correlation coefficient −0.15). Cluster analysis resolved all the genotypes into four major clusters. Among germplasm lines, TSG-313 had high seed weight of 7.05 g/100 seeds, while TSG-325 had highest grain yield of 124.4 g/plant as against control variety. Germplasm lines with high heritability scores would help us to utilise them in recombination breeding