Управление производственным процессом на предприятии

В выпускной квалификационной работе будет рассмотрена оптимизация производственного процесса на деревообрабатывающем предприятии в рамках управления производственным процессом.In the final qualifying work will consider the optimization of the production process at the woodworking enterprise in the management of the production process

Технологические решения для строительства эксплуатационной наклонно-направленной скважины глубиной 2680 метров Катыльгинском нефтяном месторождении (Томская область)

Цель работы – рассмотреть амбарное и безамбарное бурение, сравнить, описать преимущества. В процессе исследования проводились разбор и исследование процесса бурения по безамбарной и амбарной технологии. В результате исследования были выявлены преимущества использования безамбарной технологии.The purpose of the work is to examine the barn and bezambar drilling, compare, describe the advantages. In the course of the study, the drilling process was analyzed and studied in the case of bezambar and granary technology. As a result of the research, the advantages of using the zero-bar technology were revealed

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4

A body of experimental evidence suggests that T cells mediate neuroprotection following CNS injury; however, the antigen specificity of these T cells and how they mediate neuroprotection are unknown. Here, we have provided evidence that T cell-mediated neuroprotection after CNS injury can occur independently of major histocompatibility class II (MHCII) signaling to T cell receptors (TCRs). Using two murine models of CNS injury, we determined that damage-associated molecular mediators that originate from injured CNS tissue induce a population of neuroprotective, IL-4-producing T cells in an antigen-independent fashion. Compared with wild-type mice, IL-4-deficient animals had decreased functional recovery following CNS injury; however, transfer of CD4+ T cells from wild-type mice, but not from IL-4-deficient mice, enhanced neuronal survival. Using a culture-based system, we determined that T cell-derived IL-4 protects and induces recovery of injured neurons by activation of neuronal IL-4 receptors, which potentiated neurotrophin signaling via the AKT and MAPK pathways. Together, these findings demonstrate that damage-associated molecules from the injured CNS induce a neuroprotective T cell response that is independent of MHCII/TCR interactions and is MyD88 dependent. Moreover, our results indicate that IL-4 mediates neuroprotection and recovery of the injured CNS and suggest that strategies to enhance IL-4-producing CD4+ T cells have potential to attenuate axonal damage in the course of CNS injury in trauma, inflammation, or neurodegeneration

Working Fluid Stability in Large-Scale Organic Rankine Cycle-Units Using Siloxanes—Long-Term Experiences and Fluid Recycling

The results in this work show the influence of long-term operation on the decomposition of working fluids in eight different organic rankine cycle (ORC) power plants (both heat-led and electricity-led) in a range of 900 kW el to 2 MW el . All case study plants are using octamethyltrisiloxane (MDM) as a working fluid; the facilities are between six to 12 years old. Detailed analyses, including the fluid distribution throughout the cycle, are conducted on one system. All presented fluid samples are analyzed via head space gas chromatography mass spectrometry (HS-GC-MS). Besides the siloxane composition, the influence of contaminants, such as mineral oil-based lubricants (and their components), is examined. In most cases, the original working fluid degrades to fractions of siloxanes with a lower boiling point (low boilers) and fractions with a higher boiling point (high boilers). As a consequence of the analyses, a new fluid recycling and management system was designed and tested in one case study plant (Case Study #8). Pre-post comparisons of fluid samples prove the effectiveness of the applied methods. The results show that the recovery of used working fluid offers an alternative to the purchase of fresh fluid, since operating costs can be significantly reduced. For large facilities, the prices for new fluid range from € 15 per liter (in 2006) to € 22 per liter (in 2013), which is a large reinvestment, especially in light of filling volumes of 4000 liters to 7000 liters per unit. Using the aforementioned method, a price of € 8 per liter of recovered MDM can be achieved