An empirical analysis of habit and addiction to antibiotics

Because of bacterial resistance, current antibiotic consumption is reinforced by past use, and future utility is lower. The purpose of this article is to provide evidence on habit and addictive behavior toward antibiotics by exploring variations in the average consumption of antibiotics across 20 Italian regions. Using a balanced panel data set (2000-2009), we estimate myopic and rational addiction models, in which antibiotic consumption depends upon demographic and socioeconomic characteristics of the population, the supply of health care in the community, antibiotic price, and the "capital stock” of endogenous bacterial resistance measured by past and future consumption. Our empirical evidence shows that past antibiotic consumption stimulates current consumption and is also consistent with the rational addiction hypothesis. The low price elasticity of antibiotic demand suggests that policy measures targeted at antibiotic co-payments may not be effective in controlling antibiotic consumption. There is scope for other policy interventions, such as incentives and information campaigns targeted at doctor

Microvascular alterations in hypertension and vascular aging

Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and reduced regenerative capacity of the endothelium. Different phenotypes of hypertension have been described in younger and adult subjects with hypertension. In younger patients functional and structural alterations of resistance arteries occur as the earliest vascular alterations which have prognostic significance and may contribute to stiffness of large arteries through wave reflection. In individuals above age of 50 years as well as in subjects with long-lasting elevated blood pressure, vascular changes occur predominantly in conduit arteries which become stiffer. Activation of renin-angiotensin-aldosterone and endothelin systems plays a key role in endothelial dysfunction, vascular remodelling, and aging by inducing reactive oxygen species production, and promoting inflammation and cell growth

Use of Perylene Diimides in Synthetic Photochemistry

Perylene diimides (PDIs) are valuable organic chromophores that stand out for their outstanding optical and redox properties. Owing to these features, PDIs have emerged as prominent dyes capable of acting as photocatalysts for numerous relevant organic transformations. This Minireview highlights the recent advances in the application of PDIs in organic photocatalysis. The various mechanistic pathways of the photo-reduction reaction of aryl halides, recently proposed in independent studies, are discussed with an eye to unsolved challenges and forward-looking opportunities regarding the use of PDIs within this field

Assessment of multiaxial fatigue life prediction methodologies for Inconel 718

Abstract Fatigue life prediction methodologies for the assessment of the structural integrity of safety critical components in modern turbine engines require a close integration of advanced multiaxial fatigue life prediction procedures and of specific multiaxial tests, representative of the service conditions of turbine engine components and materials. The objective of the research work presented in this paper is to extend currently employed methodologies for the assessment of fatigue strength of turbine engines disks by integrating suitable multiaxial fatigue criteria and test results of multiaxial fatigue experiments conducted on Inconel 718 material at temperatures similar to those experienced by the disc materials during service. Smooth tubular specimens of Inconel 718 have been employed for conducting tension/torsion strain controlled high temperature fatigue tests. Specimens have been cut out from forged parts utilised for the production of engine discs, thus preserving the typical properties of disc materials (microstructure, basic mechanical properties, etc.). Different models/criteria have been evaluated by comparing fatigue life predictions and multiaxial fatigue experiments. It's well known that agreement of life predictions with experimental life is strongly affected not only by the choice of the multiaxial fatigue criteria but also by the way the reference fatigue data are integrated in the criteria. Therefore, specific multiaxial fatigue tests have been carried out, in order to validate and to improve the assessment capabilities of the lifing procedures. Moreover, multiaxial fatigue tests permit advances in the basic understanding of materials behaviour that might be utilised in the processes of declaring component service lives

Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies

Background: Parkinson's disease (PD) is the most common neurodegenerative disease after Alzheimer's dementia. Whereas the exact etiology of PD remains unknown, risk of developing PD seems to be related to a combination of genetic and environmental factors. This also includes abnormal exposure to trace elements of nutritional and toxicological interest. Objectives: In this systematic review and meta-Analysis, we summarized the results of case-control studies comparing levels of selenium, copper, iron, and zinc in PD patients and controls in either blood (whole blood, serum/plasma) or cerebrospinal fluid (CSF). Methods: We performed a systematic PubMed search selecting studies reporting trace element levels in different specimens of patients and controls. We performed a meta-Analysis using a random-effect model to compute the weighted mean differences (WMD) and corresponding 95% CI of selenium, copper, iron, and zinc levels in the blood or CSF of patients and their matched controls. Results: We retrieved 56 papers reporting data for selenium (cases/controls: 588/721), copper (2,190/2,522), iron (2,956/3,469), and zinc (1,798/1,913) contents in CSF and blood. Cases showed considerably higher levels of selenium in CSF compared with controls (+51.6%; WMD 5.49; 95% CI 2.82 to 8.15), while levels in serum were similar (-0.2%; WMD-0.22; 95% CI-8.05 to 7.62). For copper, cases showed slightly higher levels in CSF and slightly lower concentrations in serum (+4.5%; WMD 1.87; 95% CI-3.59 to 7.33, and-4.5%; WMD-42.79; 95% CI-134.35 to 48.76, respectively). A slight increase was also found for CSF iron-levels (+9.5%; WMD 9.92; 1.23 to 18.61), while levels were-decreased in serum/plasma (-5.7%; WMD-58.19; 95% CI-106.49 to-9.89) and whole blood (-10.8%; WMD-95.69; 95% CI-157.73 to-33.65). Conversely, for zinc cases exhibited lower levels both in CSF (-10.8%; WMD-7.34; 95% CI-14.82 to 0.14) and serum/plasma (-7.5%; WMD-79.93; 95% CI-143.80 to-16.06). A longer duration of the disease tends to be associated with overall lower trace element levels in either CSF or blood. Conclusions: Due to the study findings and the greater relevance of the CSF compartment compared with the circulating peripheral ones, this meta-Analysis suggests that overexposure in the central nervous system to selenium, and possibly to copper and iron, may be a risk factor of the disease, while zinc might have a protective-effect

Selenium and other trace elements in the etiology of Parkinson’s disease: a systematic review and meta-analysis of case-control studies

.INTRODUCTION Parkinson’s disease (PD) is a neurodegenerative illness recognised as the most common neurological disorder after Alzheimer’s dementia. Whereas the exact PD etiology remains unknown, risk of developing PD seems to be related to an interrelation of genetic and environmental factors, including also altered exposure to trace elements. In this systematic review and meta-analysis, we updated and summarized the results of epidemiologic case-control studies comparing levels of selenium, copper, iron and zinc in PD patients with healthy subjects in either blood (as whole blood, serum or plasma) and cerebrospinal fluid (CSF). MATERIALS AND METHODS We performed a systematic PubMed search and we included in our assessment only studies reporting demographic and disease-related characteristics, as well as trace element levels in different specimens (whole blood, serum/plasma and CSF). We then performed a meta-analysis of mean differences of trace element levels between cases and controls, using a random-effect model computing the weighted mean differences (WMD) and corresponding 95% confidence intervals (CI) to assess the association between serum/plasma, whole blood, CSF and selenium, copper, iron and zinc with Parkinson’s disease. RESULTS We retrieved 55 papers reporting data for selenium (588 cases and 721 controls), copper (2190 and 2522), iron (2843 and 3434), and zinc (1798 and 1913). Cases showed higher levels of selenium in CSF compared with controls (WMD=5.49; 95%CI 2.82 to 8.15), while levels in serum were similar (WMD=-0.22; -8.05 to 7.62). For copper cases showed higher levels in CSF and lower in serum compared to controls (WMD=1.87; -3.59 to 7.33, and -42.79, -134.35 to 48.76 respectively). Same results were found for iron in CSF (WMD=6.54; -1.97 to 15.04) and in serum/plasma (WMD=-58.19; -106.49 to -9.89 and whole blood (WMD=-95.69; 157.73 to -33.65). On the converse, cases had lower levels of zinc both in CSF (WMD=-7.34; -14.82 to 0.14) and serum/plasma (WMD=-79.93; -143.80 to -16.06). CONCLUSIONS Results of this systematic review and meta-analysis suggests that overexposure to environmental selenium, copper and iron may be risk factors for PD onset or progression. Alternatively, some variation in levels of these trace elements may occur as a consequence of the disease. Considering the burden of PD in the world population, further investigation of trace element exposure in this disease is therefore warranted, especially to plan possible prevention measures

NaOCl and EDTA irrigating solutions for endodontics: SEM findings

Premolars roots of humans were manually instrumented with K-type files and irrigated with different solutions to evaluate the rate of cleaning of endodontic surface. Root canals irrigated with 0.9% saline solution or H2O2 (10 volumes) showed the presence of predentin and amorphous smear layer. Thick smear layer was always present on endodontic walls rinsed with 5% solution of NaOCl. Specimens treated with 0.2% solution of EDTA showed partially clean dentinal tubules orifices and remnants of a thin smear layer. Occasional uninstrumented areas of the same roots presented smear layer remnants and predentin with calcified bacteriae. The root canals irrigated with NaOCl and EDTA solutions alternated after each instrument showed at the dentin surface thick smear layer: only few dentinal tubules orifices were visible.Endodontic surface of root canals irrigated with NaOCl during instrumentation and finally rinsed with EDTA solutions showed the most homogeneous ultrastructural pictures: partially clean dentinal orifices were detectable in the whole canals.Les canaux de la racine dentaire des prémolaires humaines ont été instrumentés manuellement avec files K type et ensuite irrigués avec différentes solutions pour évaluer les conditions de netteté de la surface endodontique.Les canaux irrigués avec une solution saline à 0,9% ou de H2O2 (10 volumes) ont démontré la présence de prédentine ou d’une couche de tissu salie. Cette couche était toujours présente sur la paroi endodontique lavée avec une solution de NaOCl à 5%. Les exemplaires traités avec une solution de EDTA à 0,2% ont démontré une netteté partielle des orifices tubulaires dentinaires et seulement un mince résidu non propre. Les zones non instrumentées de la même racine présentaient au contraire des résidus et une prédentine avec nombreuses bactéries calcifiées. Les canaux irrigués avec une solution de NaOCl et EDTA alternée ont démontré la présence d’une épaisse couche non propre et la visualisation de quelques orifices tubulaires. La surface endodontique des canaux de la racine irriguée avec NaOCl pendant l’instrumentation et ensuite lavée avec EDTA a démontré les images ultrastructurales les plus homogènes: les orifices dentinaires partiellement nettoyés pouvait être visualisés sur toute la surface du canal

Upper critical field in {Ba1−x_{1-x}Kx_xBiO3_3}: magnetotransport versus magnetotunneling

Elastic tunneling is used as a powerful direct tool to determine the upper critical field $H_{c2}(T)$ in the high-$T_c$ oxide Ba$_{1-x}$K$_x$BiO$_3$. The temperature dependence of $H_{c2}$ inferred from the tunneling follows the Werthamer-Helfand-Hohenberg prediction for type-II superconductors. A comparison will be made with resistively determined critical field data.Comment: 4 pages incl. 5 figure

Rituximab for people with multiple sclerosis

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The main objective is to assess the benefits and harms of rituximab compared to placebo or another DMT for people with multiple sclerosis. Specific comparisons include:. rituximab compared with placebo or other DMTs as first choice treatment for relapsing forms of MS; rituximab when switching from another DMT compared with placebo or other DMTs for relapsing forms of MS; rituximab compared with placebo or other DMTs as first choice treatment for progressive forms of MS; and rituximab when switching from another DMT compared with placebo or other DMTs for progressive forms of MS