Alien Registration- Frasier, Ethel G. (Calais, Washington County)

https://digitalmaine.com/alien_docs/1173/thumbnail.jp

Alien Registration- Macdonald, Ethel G. (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/11802/thumbnail.jp

Alien Registration- Beyea, Ethel G. (Easton, Aroostook County)

https://digitalmaine.com/alien_docs/26590/thumbnail.jp

Light-Activated Antimicrobial Surfaces Containing Quantum Dots for the Prevention of Hospital-Acquired Infections

This thesis details the development of effective light-activated antimicrobial polymers for use in healthcare environments, with the aim of reducing hospital-acquired infections (HAIs). The overuse and misuse of antibiotics is the most important factor that has led to increased incidence of multi-drug resistant HAIs. In the hospital setting where there is an abundance of immunosuppressed patients and often hygiene protocols are not strictly followed, HAIs can spread quickly, leading to increased length of hospital stay, morbidity and mortality and high healthcare costs. Self-disinfecting surfaces can reduce the incidence of HAIs by reducing the levels of bacteria on frequently touched hospital surfaces that serve as bacterial reservoirs, thus reducing the risk of HAI transmission. Quantum dots (QDs), extremely small nanoparticles that exhibit unique size-dependent properties, combined with photosensitisers display potent strong bactericidal activity upon incorporation into polymer surfaces. When irradiated under ambient white light, polymer surfaces induce the lethal photosensitisation of a range of Gram-positive and Gram-negative bacteria through the production of reactive oxygen species (ROS). ROS cause irreversible damage leading to cell apoptosis and death by attacking bacterial cells in a non-specific fashion thus making the development of resistance unlikely. Polyurethane substrates were impregnated with QDs and photosensitiser dye (crystal violet) using a modified version of the simple and easily scalable dipping procedure known as the “swell-encapsulation-shrink” technique. Solely cadmium-free, indium-based QDs were used in this study, thereby circumventing issues regarding toxicity arising from the release of cadmium ions from traditional, commonly prepared QDs such CdTe, CdSe and CdS. Materials were characterised using techniques such as UV-Vis absorbance spectroscopy, fluorescence spectroscopy and transmission electron microscopy. The prepared polymer substrates were activated under white light conditions mimicking those used in the hospital (~500 – 6000 lux). In order to deduce the photochemical pathway responsible for light-activated antibacterial activity, whether Type I, Type II or both, the antimicrobial surfaces were tested in a series of microbiological assays using specific ROS inhibitors and quenchers. The surfaces were tested against a range of nosocomial pathogens including Escherichia coli, Staphylococcus aureus, epidemic methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The novel materials described in this thesis demonstrate very strong self-disinfecting properties even under low light levels, demonstrating their potential for use in hospitals to reduce HAIs without the use of antibiotics

Contribution of Insect Pollination to Macadamia integrifolia Production in Hawaii

The honeybee, Apis mellifera, is commonly accepted to be an important pollinator in many agricultural crop systems in Hawaii. However, specific details on the importance of A. mellifera, along with other insect visitors have not been determined for macadamia nut orchards in Hawaii. Reductions in feral honeybee populations in Hawaii attributable to invasions by varroa mites (Varroa destruc- tor) and small hive beetle (Aethina tumida) have resulted in growers becoming dependent on managed bees, requiring increased understanding of the role they play as pollinators. Several parameters determining the contributions of insect pollinators in macadamia nuts were measured: (1) species richness and abun- dance of insects visiting macadamia flowers, (2) the effects of insect pollination in regards to fruit set, fruit retention, fruit size, and weight, and (3) insect pollen removal efficacy based on the mean number of pollen grains an individual insect removed from the stigma while foraging on a macadamia flower. The results from data collected in the study orchard showed that while the order Diptera ranked highest in species richness (9 species), A. mellifera was the most abundant species visiting the macadamia inflorescences (62.7% in abundance, with an average of 17 honeybees seen per 15 minutes compared to 8 flies per 15 minutes). Inflores- cences that were accessible to insects for pollination produced higher fruit sets and yield compared to inflorescences from which insect visitation was excluded. Abundance, foraging behavior and stigma contact, suggested that honeybees are the greatest contributors to macadamia nut pollination over other insects observed in the orchard. The hoverflies (Syrphidae) observed in the orchard may have con- tributed to pollination, but likely to a lesser extent than the honeybees due to the low abundance of the flies

A Second Study of the Statistics of Pulmonary Tuberculosis: Marital Infection.

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Nurses\u27 Alumnae Association Bulletin - Volume 2 Number 2

Coming Events Come On, \u2732 Ballot for Officers Hospital News Legislation Scholarship Fund Notes Refresher Course Correspondence Use of Heparin in Modern Treatment The Jefferson Medical College Library Nursing School Education Action - Camera - Seniors Degrees Received Engagements Weddings Births Deaths Attention Alumnae Bulletin Progress Of Special Interest Army Assignments Organized Staff Meeting

Middle to upper eocene dinoflagellate cysts from Punta del Este and colorado basins, mid latitude southwest Atlantic Ocean

The analysis of middle Eocene dinoflagellate cyst assemblages from sites at Punta del Este (~36°S, Uruguay) and Colorado (~38°S, Argentina) basins allows to interpret ocean circulation patterns on the South American Shelf prior to the opening of the Drake Passage. The assemblages contain endemic-Antarctic taxa such as Enneadocysta, Deflandrea, Vozzhennikovia and Spinidinium, which are also dominant in several circum-Antarctic sites, located southern 45°S. Enneadocysta dictyostila is the most abundant species recorded from the studied sites and the unique member of the endemic assemblage apparently tolerant to warm surface waters. The presence of endemic taxa at mid latitudes has been related to a strong clockwise subpolar gyre favoured by the partial continental blockage of the Tasmanian Gateways and the Drake Passage. The distribution of the dinoflagellate cyst assemblages along the South Atlantic Ocean Shelf can be explained by a similar dynamical mechanism induced by a cyclonic subpolar gyre on the South Atlantic Ocean. The western boundary current of this gyre, starting on the west Antarctic continental slope, would follow a similar path to the present Malvinas Current on the Patagonian slope, which introduce cold oceanic waters to the shelf and intensifies the northward shelf transport. In the same way, during the middle Eocene the western boundary current of a proto-Weddell Gyre transported the circum-Antarctic waters and the endemic taxa northward along the Southwestern Atlantic Shelf. The opening and deepening of the Tasmanian Gateway and Drake Passage and the development of an incipient Antarctic Circumpolar Current during the latest Eocene-Oligocene disrupted the subpolar gyres and promoted the extinction of the endemic species

Safety and preliminary efficacy of vorinostat with R-EPOCH in high-risk HIV-associated non-Hodgkin\u27s lymphoma (AMC-075)

We performed a phase I trial of vorinostat (VOR) given on days 1 to 5 with R-EPOCH (rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) in patients with aggressive HIV-associated non-Hodgkin lymphoma. VOR was tolerable at 300 mg and seemingly efficacious with chemotherapy with complete response rate of 83% and 1-year event-free survival of 83%. VOR did not significantly alter chemotherapy steady-state concentrations, CD4+ cell counts, or HIV viral loads. Vorinostat (VOR), a histone deacetylase inhibitor, enhances the anti-tumor effects of rituximab (R) and cytotoxic chemotherapy, induces viral lytic expression and cell killing in Epstein-Barr virus-positive (EBV+) or human herpesvirus-8-positive (HHV-8+) tumors, and reactivates latent human immunodeficiency virus (HIV) for possible eradication by combination antiretroviral therapy (cART). We performed a phase I trial of VOR given with R-based infusional EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) (n = 12) and cART in aggressive HIV-associated B-cell non-Hodgkin lymphoma (NHL) in order to identify safe dosing and schedule. VOR (300 or 400 mg) was given orally on days 1 to 5 with each cycle of R-EPOCH for 10 high-risk patients with diffuse large B-cell lymphoma (1 EBV+), 1 EBV+/HHV-8+ primary effusion lymphoma, and 1 unclassifiable NHL. VOR was escalated from 300 to 400 mg using a standard 3 + 3 design based on dose-limiting toxicity observed in cycle 1 of R-EPOCH. The recommended phase II dose of VOR was 300 mg, with dose-limiting toxicity in 2 of 6 patients at 400 mg (grade 4 thrombocytopenia, grade 4 neutropenia), and 1 of 6 treated at 300 mg (grade 4 sepsis from tooth abscess). Neither VOR, nor cART regimen, significantly altered chemotherapy steady-state concentrations. VOR chemotherapy did not negatively impact CD4+ cell counts or HIV viral loads, which decreased or remained undetectable in most patients during treatment. The response rate in high-risk patients with NHL treated with VOR(R)-EPOCH was 100% (complete 83% and partial 17%) with a 1-year event-free survival of 83% (95% confidence interval, 51.6%-97.9%). VOR combined with R-EPOCH was tolerable and seemingly efficacious in patients with aggressive HIV-NHL