Residential mobility of middle-class and popular sectors: the city of Buenos Aires as an arrival destination

El artículo reflexiona acerca de los patrones de movilidad residencial de individuos y hogares de sectores populares y medios que residen en dos zonas de la Ciudad de Buenos Aires configuradas en torno a patrones disimiles de segregación. La movilidad residencial es un lente privilegiado para evidenciar de qué modo la experiencia de la clase es producida y reproducida en los modos de habitar. Mediante un abordaje cualitativo y biográfico hemos analizado las especificidades que presentan las movilidades residenciales de los diferentes sectores sociales. Se identifican patrones en tres dimensiones de la movilidad residencial: su espacialidad, los arreglos residenciales que los hogares despliegan y las motivaciones que guían sus desplazamientos. Los hallazgos presentados dan cuenta de los efectos que produce la posición en la estructura social sobre la movilidad residencial, así como su interacción con la propia estructuración del espacio.The article reconstructs residential mobility patterns of individuals and households from popular and middle-class sectors residing in two areas of the city of Buenos Aires, configured around dissimilar segregation patterns. Residential mobility is a powerful lens to show how the social class experience is produced and reproduced in modes of dwelling. Through a qualitative and biographical approach, we analyzed the specificities presented by residential mobilities of different social sectors. We identified patterns in the three dimensions of residential mobility: spatiality, the residential arrangements that households employ, and the motivations that guide their movements. The findings show the effects that the position in the social structure has on residential mobility, as well as its interaction with the spatial structure itself.publishedVersionFil: Cosacov, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Cosacov, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas; Argentina.Fil: Di Virgilio, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Gino Germani; Argentina.Fil: Najman, Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Sociales; Argentina.Fil: Di Virgilio, María Mercedes. Universidad de Buenos Aires. Facultad de Ciencias Sociales; Argentina.Fil: Najman, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Gino Germani; Argentina

Safety of Levetiracetam in paediatrics: a systematic review

Objective To identify adverse events (AEs) associated with Levetiracetam (LEV) in children. Methods Databases EMBASE (1974-February 2015) and Medline (1946-February 2015) were searched for articles in which paediatric patients (≤18 years) received LEV treatment for epilepsy. All studies with reports on safety were included. Studies involving adults, mixed age population (i.e. children and adults) in which the paediatric subpopulation was not sufficiently described, were excluded. A meta-analysis of the RCTs was carried out and association between the commonly reported AEs or treatment discontinuation and the type of regimen (polytherapy or monotherapy) was determined using Chi2 analysis. Results Sixty seven articles involving 3,174 paediatric patients were identified. A total of 1,913 AEs were reported across studies. The most common AEs were behavioural problems and somnolence, which accounted for 10.9% and 8.4% of all AEs in prospective studies. 21 prospective studies involving 1120 children stated the number of children experiencing AEs. 47% of these children experienced AEs. Significantly more children experienced AEs with polytherapy (64%) than monotherapy (22%) (p<0.001). Levetiracetam was discontinued in 4.5% of all children on polytherapy and 0.9% on monotherapy (p<0.001), the majority were due to behavioural problems. Conclusion Behavioural problems and somnolence were the most prevalent adverse events to LEV and the most common causes of treatment discontinuation. Children on polytherapy have a greater risk of adverse events than those receiving monotherapy

Renal malformations associated with mutations of developmental genes: messages from the clinic

Renal tract malformations (RTMs) account for about 40% of children with end-stage renal failure. RTMs can be caused by mutations of genes normally active in the developing kidney and lower renal tract. Moreover, some RTMs occur in the context of multi-organ malformation syndromes. For these reasons, and because genetic testing is becoming more widely available, pediatric nephrologists should work closely with clinical geneticists to make genetic diagnoses in children with RTMs, followed by appropriate family counseling. Here we highlight families with renal cysts and diabetes, renal coloboma and Fraser syndromes, and a child with microdeletion of chromosome 19q who had a rare combination of malformations. Such diagnoses provide families with often long-sought answers to the question “why was our child born with kidney disease”. Precise genetic diagnoses will also help to define cohorts of children with RTMs for long-term clinical outcome studies

The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors

The AMPA-type ionotropic glutamate receptors (AMPA-Rs) are tetrameric ligand-gated ion channels that play crucial roles in synaptic transmission and plasticity. Our knowledge about the ultrastructure and subunit assembly mechanisms of intact AMPA-Rs was very limited. However, the new studies using single particle EM and X-ray crystallography are revealing important insights. For example, the tetrameric crystal structure of the GluA2cryst construct provided the atomic view of the intact receptor. In addition, the single particle EM structures of the subunit assembly intermediates revealed the conformational requirement for the dimer-to-tetramer transition during the maturation of AMPA-Rs. These new data in the field provide new models and interpretations. In the brain, the native AMPA-R complexes contain auxiliary subunits that influence subunit assembly, gating, and trafficking of the AMPA-Rs. Understanding the mechanisms of the auxiliary subunits will become increasingly important to precisely describe the function of AMPA-Rs in the brain. The AMPA-R proteomics studies continuously reveal a previously unexpected degree of molecular heterogeneity of the complex. Because the AMPA-Rs are important drug targets for treating various neurological and psychiatric diseases, it is likely that these new native complexes will require detailed mechanistic analysis in the future. The current ultrastructural data on the receptors and the receptor-expressing stable cell lines that were developed during the course of these studies are useful resources for high throughput drug screening and further drug designing. Moreover, we are getting closer to understanding the precise mechanisms of AMPA-R-mediated synaptic plasticity

Evolución de la intensidad y de las escalas de la segregación residencial en Bogotá : un análisis comparativo con Santiago de Chile y São Paulo

Después de varias décadas de un crecimiento demográfico rápido, las metrópolis latinoamericanas entraron a partir de los años 1980 a una nueva fase de su desarrollo. Su peso relativo en la población urbana nacional no aumenta más (Rodríguez, 2002: 35). Al modelo de desarrollo periférico en vigor hasta entonces, se sustituyó un nuevo modelo de desarrollo, más endógeno y que funciona a una escala metropolitana. El crecimiento natural se convirtió en el motor principal del crecimiento demográfico, y las movilidades residenciales intra-urbanas en el principal factor de la dinámica de poblamiento. El espacio ya construido experimenta transformaciones y procesos de densificación rápidos : la expansión urbana se realiza ahora en los municipios limítrofes, mientras que otros polarizan el proceso de metropolización (Dureau, 2006). ¿En qué medida este cambio de modelo de desarrollo urbano se acompañó de modificaciones del esquema de segregación residencial? ¿En qué medida se complejizó el esquema segregativo tradicional, con la aparición de formas de micro-segregaciones

HIV infection and immune system in genesis of coronary lesions.

International audienc

HIV infection and immune system in genesis of coronary lesions.

International audienc