Strengthening Of Mechanical Properties Of Engineered Cementitious Composites By Addition Of Fibres

Cementitious Composite (CC) is a mixture of several materials that, when combined, create a composite that aids in the bonding of different structural components. The building sector has continued to employ this combination since ancient times. As CC is essential to the structural integrity of buildings, we sought to adjust the mix in this work to provide better outcomes for the composite. Whether it be masonry, concrete, or another component, the presence of CC increases a building's capacity by ensuring effective bonding between two structural materials in the form of a connection. Therefore, a suitable CC is required for the building. Failure may also occur in the connection, failure in the bonding of two sections, failure in a structural component, etc., since failure in the structure often comes from the CC. The made Designed Cementitious Composite (ECC), which we found to have better flexibility and more grounded strength at a less expensive expense and diminished fossil fuel byproduct, is the subject of this paper's conversation. Thusly, the designs would be better prepared to endure parallel shocks welcomed on by seismic anxieties. Since its commencement in the mid 1990s, this article has analyzed the innovative work of Designed Cementitious Composites (ECC) during the most recent decade. In the materials configuration approach, the meaning of micromechanics is worried. A variety of theoretical and experimental studies are used to examine observations of distinctive ECC characteristics

New validated RP-HPLC method for simultaneous estimation of chlorpromazine and trihexyphenidyl HCl in tablets

A simple, specific and precise reverse phase high performance liquid chromatographic method was developed and validated for simultaneous estimation of Chlorpromazine and Trihexyphenidyl HCl in tablets. Quantification was achieved by using a reverse-phase C18 column (Inertsil ODS 3V, 250 mm x 4.6 mm; 5) at 31 o C. The mobile phase consisted of a mixture of ammonium acetate buffer and methanol in the ratio of 15:85 v/v at a flow rate of 1.2 mL/min. The retention times of Chlorpromazine and Trihexyphenidyl HCl were found to be 3.237 min and 5.260 min respectively. The developed method was validated as per ICH Guidelines for linearity, accuracy, precision, detection limit, quantification limit, ruggedness, robustness, specificity and system suitability. The percentage recoveries for both of the drugs from their tablets were found to be 100.34 % and 99.80 % respectively. The method may successfully be employed for the simultaneous determination of Chlorpromazine and Trihexyphenidyl HCl in pharmaceutical tablet dosage forms

ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITY OF JATROPHA CURCAS LINN.

Jatropha curcas Linn., a Bio-diesel plant known for various medicinal uses in folklore has been evaluated for few pharmacological aspects. The plant is being collected, dried and extracted by maceration method with ethanol and water. They were concentrated using vacuum distillation and the extracts were used for the evaluation of anti-inflammatory, analgesic and antibacterial activity using Formalin induced paw edema method, eddy’s hot plate method and disc diffusion method respectively. The analgesic and anti-inflammatory activity of bark water extract and leaf water extract was found significant at P<0.05 and P<0.001 respectively. The maximum analgesic effect was observed at 60min at 300mg/kg (i.p) and was similar to that of standard aspirin (50mg/kg). The edema inhibition effect was 100% for leaf water extract (300mg/kg) after 24hrs and was found effective when compared with standard Ibuprofen (50mg/kg). The antibacterial activity was also found effective at 10mg/ml

Natural carbohydrate gums based hydrogels

262-273The future of good research lies in the search of innocuous material development, based primarily on natural resources. Keeping in this perspective, four different natural gums namely, Locust bean Gum, Gum Ghatti, Gum Tragacanth, and, Gum Acacia, are used to synthesize four different novel hydrogels via free radical polymerization method with sodium acrylate and acrylamide. The synthesis is evident with the help of characterization using TGA (Thermo Gravimetric Analysis), FTIR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscope), 13C NMR (Nuclear Magnetic Resonance), and swelling studies in buffer solutions of pH 4, pH 7.4, pH 9.2, and, in distilled water. The synthesized hydrogels are potent enough in its potential utility in pharmaceuticals, drug delivery, tissue engineering as scaffolds that generally mimic human skin and in wound healing activity by incorporating the drug into it

Resistance Screening of Groundnut Advanced Breeding Lines against Collar Rot and Stem Rot Pathogens

Forty groundnut advanced breeding lines along with susceptible checks JL-24, J-11 and TMV-2 were used for collar rot (Aspergillus niger) and stem rot (Sclerotium rolfsii) disease screening. Based on the per cent number of plants affected by the collar rot pathogen, the advanced breeding lines were categorized into four groups. The lines present in group I (Resistant) having < 15% incidence, group II (Moderately resistant) having 15.1 to 30%, group III (Susceptible) having 30.1 to 45 % and group IV (Highly susceptible) having > 45% incidence. Similarly among 40 breeding lines only three lines (ICGV86699, ICGV91114 and ICGV 89280) have shown stem rot disease reaction below 3 (up to 25 % plants were symptomatic) and considered to be moderately resistant to stem rot pathogen. The advanced breeding line ICGV99058 has recorded a disease reaction of 5 scale (> 50 % of the plants symptomatic) equal to the susceptible checks which is considered to be highly susceptible to stem rot pathogen

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Not AvailableCastor is an important non-edible oilseed crop having huge industrial and export potential. It is used as an efficient lubricant for high-speed engines and as an ingredient in several commodities. There is a critical need to identify or to improve the germplasm lines with desirable characters. In the present study, 82 germplasm lines were evaluated in augmented design to estimate the genetic parameters viz., PCV, GCV, heritability and genetic advance as per cent of mean, principal component analysis and correlation studies. Results showed that the difference between PCV and GCV was low indicating less impact of environment on trait expression. Heritability (broad sense) and genetic advance as per cent of mean values were high for all the traits thus role of additive gene action is found important in governing the traits. Cluster analysis studies revealed that all the genotypes were grouped into eight clusters and cluster VIII documented the highest mean values for hundred seed weight and plant yield. The entries PRC-2 and PCS-337 recorded higher hundred seed weights of 56.5 and 48.6 g, respectively and in turn higher yield. These lines can be utilized as parents in the hybrid development programme for yield improvement. Correlation studies revealed that plant yield showed a significant positive association with all the characters except for days to 50% flowering. Thus selection for these traits viz., primary spike length, effective primary spike length, the number of effective spikes per plant, the number of capsules per spike and hundred seed weight will be advantageous in attaining higher yields.Not Availabl

Preparation, characterization, in vitro drug release and biological studies of curcumin loaded dextran sulphate–chitosan nanoparticles

Nanoformulation of curcumin, (a low molecular weight hydrophobic drug) was prepared by using dextran sulphate and chitosan. The developed nanoparticles were characterized by Dynamic Light Scattering measurements (DLS), Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD) and Differential Thermal Analysis (DTA). The prepared system showed an average size of 200-220 nm with a zeta potential value of -30 mV and showed ∼74% drug entrapment efficiency. In vitro drug release studies showed a controlled and pH dependent curcumin release over a period of one week. The cytocompatibility of bare nanoparticles was verified by MTT assay; cellular internalisation of curcumin loaded nanoparticles was confirmed by fluorescent imaging and quantified spectrophotometrically, anticancer activity of curcumin loaded nanoparticles was proved by MTT assay and reconfirmed by apoptosis assay (FACS). The results showed preferential killing of cancer cells compared to normal cells by the curcumin-loaded nanoparticles. Thus the developed curcumin loaded nanoformulation could be a promising candidate in cancer therapy

Population Dynamics of Leafhopper (Empoasca flavescens) and Thrips (Scirtothrips dorsalis) of Castor (Ricinus communis L.)

The experiment on population dynamics against leafhopper and thrips&nbsp; of castor,a field experiment was conducted during 2021 &amp; 2022 on castor (Ricinus communis) at Regional Agricultural Research Station Palem, PJTSAU. The studies on population dynamics of leafhopper (Empoasca flavescens) revealed thatthe activity of leafhoppers was moderate to heavy with maximum of 120.8 leafhoppers/3 leaves/plant was recorded during the second fortnight of December (52 SMW, 24th-31st Dec). Leafhopper population had non-significant and negative correlation with&nbsp; maximum temperature (r = -0.24 and r = -0.29, respectively), whereas it had significant assocation and negative correlation with minimum temperature, morning relative humidity, evening relative humidity as well as rainfall (r = - 0.64 - 0.50, r=-0.61 and - 0.52, respectively). Thrips infestationwas observed from October first fortnight (40 SMW 1st Oct -7th Oct) to December second fortnight (52 SMW, 24th-31st Dec) with peak infestation 31.1 thrips/spike.Thrips population had non-significant and negative correlation with&nbsp; maximum temperature ( r = -0.29), whereas it had significant assocation and negative correlation with minimum temperature, morning relative humidity, evening relative humidity as well as rainfall (r = - 0.68, r= -0.55, r=-0.63 and, r=- 0.49 respectively). Leafhopper and thrips has significant association and positive correlation with sunshine hours (r=0.55 &amp; r=0.51)

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Not AvailableAn experiment was carried out under wilt sick plot at Regional Agricultural Research Station, Palem during kharif, 2019 to identify the potential sources of resistance against wilt disease in castor. A total of 99 germplasm accessions were screened under sick plot conditions. Observations were recorded as per cent wilt incidence periodically at thirty days interval up to 150 days in each germplasm accession. The national checks viz., JI-35 & 48-1 were used as susceptible and resistant checks respectively and were sown after every five test entries. Among the accessions, nine entries have shown immune reaction to wilt disease and 48 accessions were recorded less than 20% wilt incidence and the range of wilt incidence in the remaining accessions was 21.4 to 75 %. The wilt incidence in susceptible (JI-35) and resistant (48-1) checks were 100% and 0% respectively.Not Availabl