Influence des fluides sur le comportement différé de la craie

National audienceA preliminary experimental study was performed by means of loading stages oedometric tests to highlight the role played by the fluids in the compaction of chalks. Based on a preceding research, the analysis of the North Sea oil reservoir subsidence, the oedometer adaptation to multiphase chalks (air/water or oil/water) required particular precautions. The procedure was validated successfully by the first results which highlight an effect of the fluid saturating on one-dimensional creep. The fluid according to its wettability decreases the resistance and the viscous behaviour starts earlier. Depending on the relationship between the applied stress and the pre consolidation stress, creep is more important when the sample is saturated due to the decrease of the pre consolidation stress. These aspects of the mechanical behaviour of chalks should then be taken into account in an analysis of the long-term stability of underground quarry.Une étude expérimentale préliminaire a été menée au CERMES au moyen d'essais oedométriques par paliers pour mettre en évidence le rôle joué par les fluides lors de la compaction des craies. Fondée sur une recherche précédente, l'analyse de la subsidence des réservoirs pétroliers en Mer du Nord, l'adaptation de l'essai oedométrique aux craies multiphasiques (air/eau ou huile/eau) a nécessité des précautions particulières. La procédure a été validée avec succès par les premiers résultats qui mettent en évidence un effet du fluide saturant sur le fluage unidimensionnel du matériau. En effet, le fluide selon sa mouillabilité diminue la résistance du matériau et amorce un comportement visqueux précoce. Dépendant du rapport entre la contrainte appliquée et la limite élastique, le fluage est plus important quand l'échantillon est saturé du fait de la diminution de la limite élastique qui en suit. La prise en compte de ces aspects du comportement mécanique des craies s'avère indispensable dans l'analyse de la stabilité à long terme d'anciennes carrières souterraines

Situational analysis of nutritional status among 1899 children presenting with cleft lip and/or palate in Indonesia

BACKGROUND: Given the increased risk of malnutrition in children with cleft lip and/or palate (CLP), determining their nutritional status is critical for preventing adverse surgical risks. However, no such disaggregated, national-level data are available in Indonesia. We aimed to determine the nutritional status of patients with clefts in Indonesia and to identify problems and solutions for malnutrition cases within the population.METHODS: In this cross-sectional study, we considered records of individuals who underwent primary surgery for CLP in Smile Train-sponsored facilities in Indonesia between 1 January 2016 and 31 December 2021 (n = 18 480). We only included children under the age of five with an evaluation date prior to admission date and excluded subjects with invalid data values. We classified their nutritional status by z-scores according to the World Health Organization Child Growth Standard (2006). Malnutrition cases cover four indicators - stunting, wasting, underweight, and overweight. We compared the prevalence for malnutrition cases in children under the age of five using national health survey data.RESULTS: We included 1899 records following data validation. The national prevalence of stunting (24.4%), wasting (12.5%), and overweight cases (12.9%) was high, while underweight cases (6.8%) were comparatively low. Statistical analyses showed significant differences in nutritional status based on length/height-for-age between girls and boys aged 0-5 months (P = 0.008) and 48-60 months (P = 0.001), and based on body mass index-for-age (P = 0.000) between girls and boys aged 0-5 months. Girls in different age groups exhibited a statistically significant difference in nutritional status based on length/height-for-age (P = 0.002) and weight-for-age (P = 0.017). Concurrent stunting and overweight were the most common forms of concurrent malnutrition (8.7%). We found a significant difference in the prevalence of underweight (P = 0.001) and overweight (P = 0.000) cases between children with CLP and those without CLP.CONCLUSIONS: Our findings highlight the importance of nutritional interventions for children with orofacial clefts in Indonesia, and the importance of age and gender in their design and implementation. Further investigation is necessary to explore the risks of overweight and concurrent malnutrition among this population.</p

First test on Photonic Crystal Fiber potential for broadband interferometry

International audienceThe Photonic Crystal Fibers (PCFs) are microstructured waveguides currently developed in the frame of metrology, non-linear optics or coherent tomography. PCF studies are mainly focused on the improvement of dispersion property and wide spectral single-mode operating domain. Consequently, in the astronomical context, this kind of fiber is a good candidate to design a fiber linked version of stellar interferometer for aperture synthesis. In this paper, we study the potential of these fibers taking advantage of the wide spectral single-mode operation. We propose an experimental setup acting as a two-beam interferometer using PCFs to measure fringes contrasts at four different wavelengths (670nm, 980nm, 1328nm and 1543nm) corresponding to R, I, J and H astronomical bands with the same couple of PCFs. For this purpose, we implement for the first time a piezoelectric PCF optical path modulator

Resonance Patterns of an Antidot Cluster: From Classical to Quantum Ballistics

We explain the experimentally observed Aharonov-Bohm (AB) resonance patterns of an antidot cluster by means of quantum and classical simulations and Feynman path integral theory. We demonstrate that the observed behavior of the AB period signals the crossover from a low B regime which can be understood in terms of electrons following classical orbits to an inherently quantum high B regime where this classical picture and semiclassical theories based on it do not apply.Comment: 5 pages revtex + 2 postscript figure

Controlling suction by vapour equilibrium technique at different temperatures, application to the determination of the water retention properties of MX80 clay

Problems related to unsaturated soils are frequently encountered in geotechnical or environmental engineering works. In most cases, for the purpose of simplicity, the problems are studied by considering the suction effects on volume change or shear strength under isothermal conditions. Under isothermal condition, very often, a temperature independent water retention curve is considered in the analysis, which is obviously a simplification. When the temperature changes are too significant to be neglected, it is necessary to account for the thermal effects. In this paper, a method for controlling suction using the vapour equilibrium technique at different temperatures is presented. First, calibration of various saturated saline solutions was carried out from temperature of 20 degrees C to 60 degrees C. A mirror psychrometer was used for the measurement of relative humidity generated by saturated saline solutions at different temperatures. The results obtained are in good agreement with the data from the literature. This information was then used to determine the water retention properties of MX80 clay, which showed that the retention curve is shifting down with increasing of temperature

Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [177Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model.

1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with &lt;sup&gt;177&lt;/sup&gt; Lu. TEM-1 specific tumor uptake was observed together with a non-saturation dependent liver uptake that could be related to the number of dodecane tetraacetic acid (DOTA) chelator per 1C1m-Fc. The objective of this study was to verify this hypothesis and to find the best DOTA per 1C1m-Fc ratio for theranostic applications. 1C1m-Fc was conjugated with six concentrations of DOTA. High-pressure liquid chromatography, mass spectrometry, immunoreactivity assessment, and biodistribution studies in mice bearing TEM-1 positive tumors were performed. A multi-compartment pharmacokinetic model was used to fit the data and a global pharmacokinetic model was developed to illustrate the effect of liver capture and immunoreactivity loss. Organ absorbed doses in mice were calculated from biodistribution results. A loss of immunoreactivity was observed with the highest DOTA per 1C1m-Fc ratio. Except for the spleen and bone, an increase of DOTA per 1C1m-Fc ratio resulted in an increase of liver uptake and absorbed dose and a decrease of uptake in tumor and other tissues. Pharmacokinetic models correlated these results. The number of DOTA per antibody played a determining role in tumor targeting. One DOTA per 1C1m-Fc gave the best pharmacokinetic behavior for a future translation of [ &lt;sup&gt;177&lt;/sup&gt; Lu]Lu-1C1m-Fc in patients

Measurements of permeability of saturated and unsaturated soils

The management and engineering assessments of geotechnical assets within the national transportation inventory require an appropriate knowledge of permeability of saturated and unsaturated soils. Determination of the permeability of saturated soils can be carried out using direct measurements, whereas that of unsaturated soils is often made using indirect methods based on the soil water retention curve. In this study an attempt was made to develop a novel approach for measuring the saturated and unsaturated permeability of soils. The tests were conducted on 100 mm dia. reconstituted and compacted samples of glacial till. Suctions were generated by circulating low-humidity air through a slender sand column located at the centre of the samples. Measurements of suction were made by two tensiometers located radially at the base of the samples. The drying process was terminated when the observed suctions reached or approached the limiting capacity of the tensiometers (1500 kPa). Combinations of suction measurements and volumetric strains during the drying process were used to determine the permeability by adopting analytical solutions as applicable to a radial flow condition

Electrically switching transverse modes in high power THz quantum cascade lasers.

The design and fabrication of a high power THz quantum cascade laser (QCL), with electrically controllable transverse mode is presented. The switching of the beam pattern results in dynamic beam switching using a symmetric side current injection scheme. The angular-resolved L-I curves measurements, near-field and far-field patterns and angular-resolved lasing spectra are presented. The measurement results confirm that the quasi-TM(01) transverse mode lases first and dominates the lasing operation at lower current injection, while the quasi-TM(00) mode lases at a higher threshold current density and becomes dominant at high current injection. The near-field and far-field measurements confirm that the lasing THz beam is maneuvered by 25 degrees in emission angle, when the current density changes from 1.9 kA/cm(2) to 2.3 kA/cm(2). A two-dimension (2D) current and mode calculation provides a simple model to explain the behavior of each mode under different bias conditions