Less State, More Market: University Reform in Canada and Abroad

Political, economic, and social explanations of higher education reform, and the very definition of "reform," are the main departure points of this volume. The introduction uses the examples of Canada, Austria, Germany, and Japan to show that in all these countries, reform has meant reduced state funding and control and increased reliance on market mechanisms, private sources of funding, and new forms of university governance and management.Pour expliquer la réforme universitaire, les auteurs adoptent comme points de départ des analyses politique, économique, et sociologique. Se référant aux cas canadien, autrichien, allemand, et japonais, les recherches présentées démontrent à quel point la réforme dans tous ces pays envisage une subvention publique réduite, avec moins d'intervention étatique dans les affaires universitaires, et une dépendance accrue des institutions de 2e et de 3e cycles sur les mécanismes d'un marché supposément libre, et sur de nouvelles sources privées de financement. En plus, on peut constater l'apparition de formes nouvelles de gouvernance et de management.&nbsp

Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.

During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the phylotypic period. We isolate early cardiac progenitor cells from zebrafish embryos and characterize 3838 open chromatin regions specific to this cell population. Of these regions, 162 overlap with conserved non-coding elements (CNEs) that also map to open chromatin regions in human. Most of the zebrafish conserved open chromatin elements tested drive gene expression in the developing heart. Despite modest sequence identity, human orthologous open chromatin regions recapitulate the spatial temporal expression patterns of the zebrafish sequence, potentially providing a basis for phylotypic gene expression patterns. Genome-wide, we discover 5598 zebrafish-human conserved open chromatin regions, suggesting that a diverse repertoire of ancient enhancers is established prior to organogenesis and the phylotypic period

Floral ontogeny in Dialiinae (Caesalpinioideae: Cassieae), a study in organ loss and instability

AbstractThe Caesalpinioideae are widely variable in their floral ontogeny, and among caesalpinioids, members of the polyphyletic tribe Cassieae are particularly diverse. Within the Cassieae, the monophyletic Dialiinae clade is also marked by a high degree of organ loss, particularly in the largest genus, Dialium. The purpose of this work is to explore the ontogeny of several previously undocumented species of the diverse Dialiinae clade, with the goal of building a more complete picture of floral development and evolution in this group and especially within Dialium. We have documented the floral ontogeny of six species of the Dialiinae; four from Dialium, as well as Poeppigia procera and Mendoravia dumaziana. Mode and timing of organ initiation were mostly consistent across the Dialium species studied. With the exception of Dialium dinklagei, which undergoes helical calyx initiation, all flowers initiated sepals bidirectionally. In the instances of both gains and losses of floral organs in Dialium, one trend is apparent — an absence of abaxial organs. Gains in both sepals and stamens occur in the adaxial median position, while stamens and petals which are lost are always the ventral-most organs. Organ initiation in Poeppigia and Mendoravia is unlike that seen in Dialium. Poeppigia shows a ventral to dorsal unidirectional sepal initiation, while both Poeppigia and Mendoravia display near-synchronous initiation of the corolla and staminal whorls. The taxa examined here exemplify the apparent lack of developmental canalisation seen in caesalpinioid legumes. This ontogenetic plasticity is reflective of the morphological diversity shown by flowers across the subfamily, representing what has been described as an “experimental” phase in legume floral evolution

Serum-induced changes in the physiology of mammalian retinal glial cells: role of lysophosphatidic acid

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65571/1/j.1469-7793.1998.445bw.x.pd

Una mirada crítica a la ética de la IA: de preocupaciones emergentes y principios orientadores a un desvelar ético

En este artículo examino el estado actual de la “segunda ola” de la ética en la inteligencia artificial (IA), la cual se centra en la integración de principios éticos fundamentales como la justicia, la privacidad, la transparencia y la explicabilidad en el diseño, uso e implementación de sistemas de IA. Argumento que, aunque esta fase ha sido criticada por su naturaleza abstracta y su falta de contextualización, es imperativo que la emergente “tercera ola” adopte un cambio paradigmático hacia un “desvelar ético”. Propongo que este desvelar ético debería involucrar un profundo y continuo proceso hermenéutico que no solo interprete cómo las tecnologías de IA reconfiguran nuestras estructuras sociales, políticas y personales, sino que también actúe como un medio de liberación del enmarcamiento tecnológico Heideggeriano. Este enfoque sugiere que la ética debe ser considerada no solo como un complemento, sino como un componente esencial y fundamental en el ciclo de vida del desarrollo de la IA, fomentando así una integración más profunda de consideraciones éticas que guíen tanto la innovación tecnológica como su implementación práctica