651 research outputs found
Solution of the infinite range t-J model
The t-J model with constant t and J between any pair of sites is studied by
exploiting the symmetry of the Hamiltonian with respect to site permutations.
For a given number of electrons and a given total spin the exchange term simply
yields an additive constant. Therefore the real problem is to diagonalize the
"t- model", or equivalently the infinite U Hubbard Hamiltonian. Using
extensively the properties of the permutation group, we are able to find
explicitly both the energy eigenvalues and eigenstates, labeled according to
spin quantum numbers and Young diagrams. As a corollary we also obtain the
degenerate ground states of the finite Hubbard model with infinite range
hopping -t>0.Comment: 15 pages, 2 figure
Plaquette bond order wave in the quarter-filled extended Hubbard model on the checkerboard lattice
An extended Hubbard model (including nearest-neighbor repulsion and
antiferromagnetic spin exchange) is investigated on the frustrated checkerboard
lattice, a two-dimensional analog of the pyrochlore lattice. Combining
Gutzwiller renormalized mean-field (MF) calculations, exact diagonalization
(ED) techniques, and a weak-coupling renormalization group (RG) analysis we
provide strong evidence for a crystalline valence bond plaquette phase at
quarter-filling. The ground state is twofold degenerate and breaks translation
symmetry. The bond energies show a staggering while the charge distribution
remains uniform.Comment: 8 pages, 6 figures, published versio
Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the inhibition of exocytosis, in the rat. The zinc chelating agent dipicolinic acid as well as captopril, an inhibitor of zinc-dependent peptidases, counteract the effect of the neurotoxin. Synthetic peptides, the sequences of which correspond to motifs present in the cytoplasmic domain of the synaptic vesicle membrane protein synaptobrevin 1 and 2, prevent the effect of the tetanus toxin light chain.
Our results indicate that zinc bound to the zinc binding motif constitutes the active site of the tetanus toxin light chain. Moreover they suggest that cleavage of synaptobrevin by the neurotoxin causes the inhibition of exocytotic release of vasopressin from secretory granules
Topological Hall effect in the A-phase of MnSi
Recent small angle neutron scattering suggests, that the spin structure in
the A-phase of MnSi is a so-called triple- state, i.e., a superposition of
three helices under 120 degrees. Model calculations suggest that this structure
in fact is a lattice of so-called skyrmions, i.e., a lattice of topologically
stable knots in the spin structure. We report a distinct additional
contribution to the Hall effect in the temperature and magnetic field range of
the proposed skyrmion lattice, where such a contribution is neither seen nor
expected for a normal helical state. Our Hall effect measurements constitute a
direct observation of a topologically quantized Berry phase that identifies the
spin structure seen in neutron scattering as the proposed skyrmion lattice
On a global differential geometric approach to the rational mechanics of deformable media
In the past the rational mechanics of deformable media was largely concerned with materials governed by linear constitutive equations. In recent years, the theory has expanded considerably towards covering materials for which the constitutive equations are inherently nonlinear, and/or whose mechanical properties resemble in some respects those of a fluid and in others those of a solid. In the present article we formulate a satisfactory global mathematical theory of moving deformable media, which includes all these aspects
Exact integral equation for the renormalized Fermi surface
The true Fermi surface of a fermionic many-body system can be viewed as a
fixed point manifold of the renormalization group (RG). Within the framework of
the exact functional RG we show that the fixed point condition implies an exact
integral equation for the counterterm which is needed for a self-consistent
calculation of the Fermi surface. In the simplest approximation, our integral
equation reduces to the self-consistent Hartree-Fock equation for the
counterterm.Comment: 5 pages, 1 figur
Collective fields in the functional renormalization group for fermions, Ward identities, and the exact solution of the Tomonaga-Luttinger model
We develop a new formulation of the functional renormalization group (RG) for
interacting fermions. Our approach unifies the purely fermionic formulation
based on the Grassmannian functional integral, which has been used in recent
years by many authors, with the traditional Wilsonian RG approach to quantum
systems pioneered by Hertz [Phys. Rev. B 14, 1165 (1976)], which attempts to
describe the infrared behavior of the system in terms of an effective bosonic
theory associated with the soft modes of the underlying fermionic problem. In
our approach, we decouple the interaction by means of a suitable
Hubbard-Stratonovich transformation (following the Hertz-approach), but do not
eliminate the fermions; instead, we derive an exact hierarchy of RG flow
equations for the irreducible vertices of the resulting coupled field theory
involving both fermionic and bosonic fields. The freedom of choosing a momentum
transfer cutoff for the bosonic soft modes in addition to the usual band cutoff
for the fermions opens the possibility of new RG schemes. In particular, we
show how the exact solution of the Tomonaga-Luttinger model emerges from the
functional RG if one works with a momentum transfer cutoff. Then the Ward
identities associated with the local particle conservation at each Fermi point
are valid at every stage of the RG flow and provide a solution of an infinite
hierarchy of flow equations for the irreducible vertices. The RG flow equation
for the irreducible single-particle self-energy can then be closed and can be
reduced to a linear integro-differential equation, the solution of which yields
the result familiar from bosonization. We suggest new truncation schemes of the
exact hierarchy of flow equations, which might be useful even outside the weak
coupling regime.Comment: 27 pages, 15 figures; published version, some typos correcte
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25
AbstractProtein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found that constitutive PKA activity was necessary to maintain a large number of vesicles in the release-ready, so-called primed, state, whereas calcineurin (protein phosphatase 2B) activity antagonized this effect. Overexpression of the SNARE protein SNAP-25a mutated in a PKA phosphorylation site (Thr-138) eliminated the effect of PKA inhibitors on the vesicle priming process. Another, unidentified, PKA target regulated the relative size of two different primed vesicle pools that are distinguished by their release kinetics. Overexpression of the SNAP-25b isoform increased the size of both primed vesicle pools by a factor of two, and mutations in the conserved Thr-138 site had similar effects as in the a isoform
Two complementary approaches for intracellular delivery of exogenous enzymes.
Intracellular delivery of biologically active proteins remains a formidable challenge in biomedical research. Here we show that biomedically relevant enzymes can be delivered into cells using a new DNA transfection reagent, lipofectamine 3000, allowing assessment of their intracellular functions. We also show that the J774.2 macrophage cell line exhibits unusual intracellular uptake of structurally and functionally distinct enzymes providing a convenient, reagent-free approach for evaluation of intracellular activities of enzymes
Development of data representation standards by the human proteome organization proteomics standards initiative.
OBJECTIVE: To describe the goals of the Proteomics Standards Initiative (PSI) of the Human Proteome Organization, the methods that the PSI has employed to create data standards, the resulting output of the PSI, lessons learned from the PSI's evolution, and future directions and synergies for the group.
MATERIALS AND METHODS: The PSI has 5 categories of deliverables that have guided the group. These are minimum information guidelines, data formats, controlled vocabularies, resources and software tools, and dissemination activities. These deliverables are produced via the leadership and working group organization of the initiative, driven by frequent workshops and ongoing communication within the working groups. Official standards are subjected to a rigorous document process that includes several levels of peer review prior to release.
RESULTS: We have produced and published minimum information guidelines describing what information should be provided when making data public, either via public repositories or other means. The PSI has produced a series of standard formats covering mass spectrometer input, mass spectrometer output, results of informatics analysis (both qualitative and quantitative analyses), reports of molecular interaction data, and gel electrophoresis analyses. We have produced controlled vocabularies that ensure that concepts are uniformly annotated in the formats and engaged in extensive software development and dissemination efforts so that the standards can efficiently be used by the community.Conclusion In its first dozen years of operation, the PSI has produced many standards that have accelerated the field of proteomics by facilitating data exchange and deposition to data repositories. We look to the future to continue developing standards for new proteomics technologies and workflows and mechanisms for integration with other omics data types. Our products facilitate the translation of genomics and proteomics findings to clinical and biological phenotypes. The PSI website can be accessed at http://www.psidev.info
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