PTTI applications at Hydro-Quebec

As a power utility, Hydro-Quebec used the PTTI techniques. The time dissemination system in the Hydro-Quebec Network (11th PTTI) is now installed in several points. A portable clock was built using a rubidium standard and associated circuitry which are necessary for the measurements. The apparatus and the experimental results obtained are described. The use of GOES synchronized clocks for making precise voltage angle measurement on the Hydro-Quebec Network is discussed. Some modifications were made on a commercial unit. Applications and results are presented

Study on the neuronal circuits implicated in postural tremor and hypokinesia

The effect of various tegmentary lesions at the level of the pontomesenchphalon in monkeys on motor function was observed. The importance of the monoaminergic mechanisms of the brainstem is discussed. The results also show the importance of the descending tegmentary rubral system and the rubroolivocerebellar circuit in controlling peripheral motor activity. The destruction of the sensory motor cortex proves to be a more effective way of eliminating spontaneous or harmaline induced tremor than the complete interruption of the pyramidal system on the level of the cerebral peduncle

Time transfer by IRIG-B time code via dedicated telephone link

Measurements were made of the stability of time transfer by the IRIG-B code over a dedicated telephone link on a microwave system. The short and long term Allan Variance was measured on both types of microwave system, one of which is synchronized, the other having free local oscillators. The results promise a time transfer accuracy of 10 microns. The paper also describes a prototype slave clock designed to detect interference in the IRIG-B code to ensure local time is kept during such interference

Inclined plate settler for emergency water treatment: final design

Previously we reported on the proof-of-concept and initial optimisation work on an inclined plate settler (IPS) for water treatment in humanitarian situations. Whilst promising results (i.e. effluent turbidity < 5 NTU) were obtained, further work was warranted to better control and design the hydraulic flocculation (floc conditioning) stage of the treatment system. This paper reports on such work. A scaled-down version of the IPS was tested in parallel with several hydraulic flocculation configurations. The first deployment of the IPS is planned for 2015

Spinal cord stimulators and radiotherapy: First case report and practice guidelines

Spinal cord stimulators (SCS) are a well-recognised treatment modality in the management of a number of chronic neuropathic pain conditions, particularly failed back syndrome and radiculopathies. The implantable pulse generator (IPG) component of the SCS is designed and operates in a similar fashion to that of a cardiac pacemaker. The IPG consists of an electrical generator, lithium battery, transmitter/receiver and a minicomputer. When stimulated, it generates pulsed electrical signals which stimulate the dorsal columns of the spinal cord, thus alleviating pain. Analogous to a cardiac pacemaker, it can be potentially damaged by ionising radiation from a linear accelerator, in patients undergoing radiotherapy. Herein we report our clinical management of the first reported case of a patient requiring adjuvant breast radiotherapy who had a SCS in situ. We also provide useful practical recommendations on the management of this scenario within a radiation oncology department

Inclined plate settling for emergency water treatment: towards optimisation

Previous work revealed the potential of an inclined plate settler (IPS) for water treatment in emergency relief applications. Whilst preliminary data demonstrated the tested IPS prototype’s capacity to achieve stable turbidity reductions, further optimisation was warranted. This paper reports on the optimisation and preliminary field testing of an IPS prototype. Trials revealed that after system modification, treatment objectives with regards to turbidity reductions (i.e. < 5 NTU) could be achieved. Such positive results were largely due to the addition of a hydraulic flocculation (conditioning) stage

Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.

Heart failure is the common final pathway of several cardiovascular conditions and a major cause of morbidity and mortality worldwide. Aberrant activation of the adaptive immune system in response to myocardial necrosis has recently been implicated in the development of heart failure. The ß-adrenergic agonist isoproterenol hydrochloride is used for its cardiac effects in a variety of different dosing regimens with high doses causing acute cardiomyocyte necrosis. To assess whether isoproterenol-induced cardiomyocyte necrosis triggers an adaptive immune response against the heart, we treated C57BL/6J mice with a single intraperitoneal injection of isoproterenol. We confirmed tissue damage reminiscent of human type 2 myocardial infarction. This is followed by an adaptive immune response targeting the heart as demonstrated by the activation of T cells, the presence of anti-heart auto-antibodies in the serum as late as 12 weeks after initial challenge and IgG deposition in the myocardium. All of these are hallmark signs of an established autoimmune response. Adoptive transfer of splenocytes from isoproterenol-treated mice induces left ventricular dilation and impairs cardiac function in healthy recipients. In summary, a single administration of a high dose of isoproterenol is a suitable high-throughput model for future studies of the pathological mechanisms of anti-heart autoimmunity and to test potential immunomodulatory therapeutic approaches