Inclusive Photoproduction of D* Mesons with Massive Charm Quarks

We have calculated the next-to-leading order cross sections for the inclusive production of D* mesons in gamma-p collisions at HERA in two approaches using massive or massless charm quarks. The usual massive theory for the direct cross section with charm quarks only in the final state was transformed into a massive theory with MS-bar subtraction by subtracting the mass divergent and additional finite terms calculated earlier in connection with the process gamma+gamma -> D*+X. This theory approaches the massless theory with increasing transverse momentum. The difference between the massive and the massless approach with MS-bar subtraction is studied in detail in those kinematic regions relevant for comparison with experimental data. With these results and including the resolved cross section which is dominated by the part originating from the charm in the photon, we compute the fully inclusive D* cross section and compare it with preliminary data from the ZEUS collaboration at HERA. We find on average good agreement.Comment: 18 pages, 9 figures, figures modified to include statistical and systematic experimental error

Many-body effects in nuclear structure

We calculate, for the first time, the state-dependent pairing gap of a finite nucleus (120Sn) diagonalizing the bare nucleon-nucleon potential (Argonne v14) in a Hartree-Fock basis (with effective k-mass m_k eqult to 0.7 m), within the framework of the BCS approximation including scattering states up to 800 MeV above the Fermi energy to achieve convergence. The resulting gap accounts for about half of the experimental gap. We find that a consistent description of the low-energy nuclear spectrum requires, aside from the bare nucleon-nucleon interaction, not only the dressing of single-particle motion through the coupling to the nuclear surface, to give the right density of levels close to the Fermi energy (and thus an effective mass m* approximately equal to m), but also the renormalization of collective vibrational modes through vertex and self-energy processes, processes which are also found to play an essential role in the pairing channel, leading to a long range, state dependent component of the pairing interaction. The combined effect of the bare nucleon-nucleon potential and of the induced pairing interaction arising from the exchange of low-lying surface vibrations between nucleons moving in time reversal states close to the Fermi energy accounts for the experimental gap.Comment: 5 pages, 4 figures; author list correcte

Intractable policy failure: the case of bovine TB and badgers

The failure to eliminate bovine TB from the English and Welsh cattle herd represents a long-term intractable policy failure. Cattle-to-cattle transmission of the disease has been underemphasised in the debate compared with transmission from badgers despite a contested evidence base. Archival evidence shows that mythical constructions of the badger have shaped the policy debate. Relevant evidence was incomplete and contested; alternative framings of the policy problem were polarised and difficult to reconcile; and this rendered normal techniques of stakeholder management through co-option and mediation of little assistance

Partitioning heritability by functional annotation using genome-wide association summary statistics

Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements, including cell type-specific elements, to estimate their polygenic contributions to heritability in genome-wide association studies (GWAS) of 17 complex diseases and traits with an average sample size of 73,599. To enable this analysis, we introduce a new method, stratified LD score regression, for partitioning heritability from GWAS summary statistics while accounting for linked markers. This new method is computationally tractable at very large sample sizes and leverages genome-wide information. Our findings include a large enrichment of heritability in conserved regions across many traits, a very large immunological disease-specific enrichment of heritability in FANTOM5 enhancers and many cell type-specific enrichments, including significant enrichment of central nervous system cell types in the heritability of body mass index, age at menarche, educational attainment and smoking behavior

3D Printed Alternative to the Standard Synthetic Flocked Nasopharyngeal Swabs Used for COVID-19 testing.

BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, can be detected in respiratory samples by Real-time Reverse Transcriptase (RT)-PCR or other molecular methods. Accessibility of diagnostic testing for COVID-19 has been limited by intermittent shortages of supplies required for testing, including flocked nasopharyngeal (FLNP) swabs. METHODS:We developed a 3D-printed nasopharyngeal (3DP) swab as a replacement of the FLNP swab. The performance of 3DP and FLNP swabs were compared in a clinical trial of symptomatic patients at three clinical sites (n=291) using three SARS-CoV-2 EUA tests: a modified version of the CDC Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel and two commercial automated formats, Roche Cobas and NeuMoDx. RESULTS:The cycle threshold (C(t)) values from the gene targets and the RNase P gene control in the CDC assay showed no significant differences between swabs for both gene targets (p=0.152 and p=0.092), with the RNase P target performing significantly better in the 3DP swabs (p & 0.001). The C(t) values showed no significant differences between swabs for both viral gene targets in the Roche cobas assay (p=0.05 and p=0.05) as well as the NeuMoDx assay (p=0.401 and p=0.484). The overall clinical correlation of COVID-19 diagnosis between all methods was 95.88% (Kappa 0.901). CONCLUSIONS:3DP swabs were equivalent to standard FLNP in three testing platforms for SARS-CoV-2. Given the need for widespread testing, 3DP swabs printed on-site are an alternate to FLNP that can rapidly scale in response to acute needs when supply chain disruptions affect availability of collection kits