Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma

Background: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. Methods: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. Results: The median PFS (mPFS) was 10.1 months (95% CI, 6.8-13.4) in the FLOT arm (n = 33) and 7.4 months (95% CI, 9.1-21.6) in the mDCF arm (n = 39) (p = 0.041). The median OS (mOS) was 12.9 months (95% CI, 9.7-16.1) in the FLOT arm and 15.4 months (95% CI, 9.1-21.6) in the mDCF arm (p = 0.622). It was found that all grade neutropenia was 51.3% vs. 72.7% (p = 0.063), febrile neutropenia was 8.3% vs. 6.3% (p = 0.743), and thrombocytopenia was 48.7% vs. 51.5% (p = 0.813) in the FLOT and mDCF arms, respectively. Anemia was 59% in the FLOT arm and 100% in the mDCF arm (p < 0.001). Grade 3-4 anemia was 7.7% in the FLOT arm and 24.2% in the mDCF arm (p = 0.052). Discussion: It was shown that the mPFS was significantly increased in the FLOT arm compared to the mDCF arm as the first-line treatment in patients with metastatic GC and GEJC. Hematological adverse events were more favorable in the FLOT arm than in the mDCF arm

Investigation of effect of somatic cell count and seasons on buffalo milk quality

Sütün somatik hücre sayısı (SHS), kimyasal kompozisyonu ve mikrobiyolojik kalitesi çiğ sütün genel kalitesi açısından en önemli özelliklerdir. Çalışmamızda manda sütlerinin mevsimsel olarak SHS, kimyasal kompozisyonu ve mikrobiyolojik kaliteleri ölçülmüş, bu parametreler üzerinde mevsim etkisi araştırılmıştır. SHS açısından yaz numunesi maksimum değeri 465000 adet/ml ile en yüksek seyrederken (ortalama 233500 adet/ml) genel olarak mikrobiyolojik kriterler açısından da yaz mevsimi numunelerinin toplam bakteri sayısı, Enterobacteriacea sayısı, koliform sayısı ve E. coli sayısı değerlerinin diğer mevsimlere göre yüksek olduğu görüldü. Kimyasal kompozisyon için ise süt yağı ve laktoz değerlerinin mevsimden etkilenmediği, ancak yaz numunelerinin protein, kuru madde ve yağsız kuru madde değerlerinin (sırasıyla ortalama değerleri %5.53, %18.83, %10.34) en yüksek düzeyde seyrettiği görülmüştür. Sıcak mevsimler açısından hijyen tedbirlerinin geliştirilmesi ve meme sağlığı açısından ek önlemler alınması gerektiği düşünülmektedir.The somatic cell count (SCC), chemical composition and microbiological quality of milk are the most important features in terms of overall quality of raw milk. In our study, the seasonal SCC, chemical composition and microbiological qualities of the milk obtained were measured, and the seasonal effect on these parameters was investigated. In terms of SCC, the maximum value of the summer sample was the highest with 465000 units/ml (average 233500 units/ml), while in terms of microbiological criteria, the total bacteria count, Enterobacteriacea count, coliform count and E. coli count values were found to be higher than other seasons. As for the chemical composition, it was observed that the milk fat and lactose values were not affected by the season, but the protein, dry matter and non-fat dry matter values of the summer samples (respectively average values 5.53%, 18.83%, 10.34%) were at the highest level. It is considered that hygiene measures should be developed in terms of hot seasons and additional measures should be taken in terms of udder health