Digital design tools versus architectural representation and design approach: a reading off architectural press

Conference: 31st International Conference on Education and Research in Computer Aided Architectural Design in Europe (eCAADe) -- Location: Delft Univ Technol, Fac Architecture, Delft, NETHERLANDS -- Date: SEP 18-20, 2013This study aims to investigate the relation between evolving graphic representations and due to new digital tools and how they affect architects' approach to design process. In order to do this, Yapi Magazine being published since 1973 in Turkey will be retrieved and data related to types of architectural design representation used will be recorded. The study will conclude with an evaluation of new representation means such as 3D render, other 3D digital products and diagrams and how they have influenced new approach to design.Autodesk GmbH; Bentley Sys

Radiologic and histopathologic review of rare benign and malignant breast diseases

High social awareness of breast diseases and the rise in breast imaging facilities have led to an increase in the detection of even rare benign and malignant breast lesions. Breast lesions are associated with a broad spectrum of imaging characteristics, and each radiologic imaging technique reflects different characteristics of them. We aimed to increase familiarity of the radiologist with these uncommon lesions as well as correlate histopathologic findings with the radiologic imaging features of the tumors. Histopathologic examination is necessary in the evaluation of such breast lesions, particularly when radiologic images are not definitive for a specific diagnosis

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Competition Management And Competition Measurement Strategies

Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2001Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2001Bu çalışma, rekabet gücü kavramını, bir firmanın ticari çevresinin detaylı bir tahlilini yapmak suretiyle o firmanın rekabet gücünü ölçebilecek bir yapı yoluyla, tanımlamayı önermektedir. Bunu yaparken, literatürde yer alan sayısal yöntemlerin yerine, günümüzün çalışma koşullarına ve esneklik ihtiyacına uygun, anketlere ve piyasa gözlemlerine dayanan pratik ve hızlı tespit imkanı veren bir yöntem tercih edilmiştir. Rekabet gücü kavramı, müşteri değerleri, hissedar değerleri, firmanların davranış biçimleri ve reaksiyonlarının bir bütünü olarak düşünülmüş ve herbir bileşeninin rekabet gücüne etkisi incelenmiştir. Rekabet gücü kavramında sürdürülebilirlik ilkesi ortaya konmuştur. Sürdürülebilirlik, firmanın, değişen rekabet çevresine karşı hareket yeteneğini korurken, müşterileri ve hissedarları gözünde, rekabet konumunu koruma ve geliştirme potansiyeli olarak tanımlanmıştır. Sürdürülebilirliği sağlayıcı faktörlerin dengeleri üzerinde çalışılmıştır. Rekabet kaynakları ve bu kaynakların rekabet kriterlerine olan etkileri detaylı bir şekilde incelenmeye çalışılmış ve örnek olarak alınan bir firmadaki 3 farklı anket uygulamasıyla da bu önerilerin doğruluğu desteklenmeye çalışılmıştır.In this study, competition strength concept, is defined and measured in detailed analysis of the commercial environment in which the company is acting. The methods prefered for the measurement are fast and practical methods which are based on questionnaries and market researches being adaptable to daily working conditions and flexibility requirements. The key factors in competition are, customer values, shareholder values and the organization’s ability to act and react. All these factors and their influence to competition are deeply analysed. Another concept on the competition is sustainability which is a measure describing the potential of an organization to maintain or improve its competitive position in the eyes of its customers and shareholders while having the ability to act and react within a changing competitive environment. Factors providing the sustainability are defined. Competition sources and their influence on competition criteria, are the subject of the theorethical part. All previous parts are applied in the last chapter with 3 questionnaries on one digital broadcasting firm. The results are represented and supplied with the theorethical parts in the last section.Yüksek LisansM.Sc

Ekonomik Faktörlerin Evlilik Kalitesine Etkisi: Bir Dyadic Model Testi

This study was conducted in three different socioeconomic districts in Ankara to examine the effect of economic factors on the quality of marriages. This study initially collected data from 211 married couples (422 married individuals), to develop the Marital Quality Scale (MQS). For the Family Economic Strain Scale (FESS), an adaptation study was performed. Then, the researchers met with 278 married couples (556 married individuals) and by using the data obtained, the Marital Quality Model Test was established. The Cronbach's alpha coefficient of the MQS was calculated according to data set for the 211 married couples, and its Cronbach's alpha coefficient was calculated according to the data set from the 278 married couples. They were found to be .97 and .96, respectively. The MQS is a 5-factor with 42 items. This study determined that the MQS is a valid and reliable scale for Turkey. A dyadic model test was performed, and this study examined the role of “couple burnout” (mediation or moderation) in the relationship between “family economic strain” and “marital quality” of males and females. The mediation and the moderation roles of couple burnout were analyzed using the mediation model of heterosexual couple solidarity (Actor-Partner Interdependence Mediation Model–APIMeM) and the moderation model of heterosexual couple solidarity (Actor-Partner Interdependence Moderation Model–APIMoM), respectively. The model test results showed that the relationship between economic strain and marital quality did not vary by couple burnout; however, as the couple burnout perceived by couples increased, the marital quality of each spouse significantly decreased. Moreover, economic strain experienced by spouses decreased marital quality by mediating the couple burnout experienced by individuals or their spouses. Lower marital quality was mostly due to his/her own couple burnout, and slightly because of the couple burnout experienced by his/her spouse. In light of its findings, this study offers suggestions to researchers, academicians and institutions.Bu çalışma, ekonomik faktörlerin evlilik kalitesine etkisini incelemek amacıyla Ankara’da farklı sosyo-ekonomik düzeydeki üç ilçede yürütülmüştür. Bunun için öncelikle 211 evli çiftten (422 evli birey) veri toplanarak Evlilik Kalitesi Ölçeği (EKÖ) geliştirilmiş ve Aile Ekonomik Güçlük Ölçeğinin (AEGÖ) uyarlama çalışması yapılmıştır. Daha sonra 278 evli çift (556 evli birey) ile görüşülerek elde edilen verilerle Evlilik Kalitesi Model Testi kurulmuştur. EKÖ’nün 211 evli çifte (422 evli birey) ilişkin veri setinden hesaplanan Cronbach Alpha katsayısı .97 ve 278 evli çifte (556 evli birey) ilişkin veri setinden hesaplanan Cronbach Alpha katsayısı ise .96 bulunmuştur. Son formu ile EKÖ 5 faktörlü ve 42 maddeden oluşan bir ölçektir. Çalışma sonucunda EKÖ’nün ülkemiz için geçerli ve güvenilir bir ölçek olduğu belirlenmiştir. Yapılan dyadic model testi ile kadın ve erkeklerin “aile ekonomik güçlüğü” ile “evlilik kalitesi” arasındaki ilişkide “eş tükenmişliği”nin rolü (mediation ve moderation) incelenmiştir. Eş tükenmişliğinin aracı rolü, heteroseksüel çift dayanışması aracı modeli ile; etkileşim rolü ise heteroseksüel çift dayanışması etkileşim modeli ile analiz edilmiştir. Model testinden elde edilen sonuçlar, ekonomik güçlükle evlilik kalitesi arasındaki ilişkinin eş tükenmişliğine bağlı olarak (moderation) değişmediğini, ancak çiftlerin eş tükenmişliği arttıkça, eşlerin her ikisinin de evlilik kalitesinin anlamlı olarak düştüğünü göstermiştir. Bunun yanı sıra, eşlerin yaşadıkları ekonomik güçlük, kendilerinin ve/veya eşlerinin yaşadıkları eş tükenmişliği aracılığıyla (mediation) evlilik kalitelerini düşürmektedir. Eşin evlilik kalitesinin düşük olması ise büyük ölçüde kendi eş tükenmişliği, nispeten de eşinin yaşadığı eş tükenmişliği nedeniyle gerçekleşmektedir. Çalışmadan elde edilen bulgular doğrultusunda araştırmacılara, akademisyenlere, kişilere ve kurumlara yönelik çeşitli öneriler sunulmuştur

Neonatal neurodegeneration in alzheimer's disease transgenic mouse model

Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the diagnosis of the disease, is highly correlated with the clinical symptoms. Several proteomics studies were performed using animal models to monitor the alterations of the brain tissue proteome at different stages of AD. However, proteome changes in the brain regions of newborn transgenic mouse model have not been investigated yet. To this end, we analyzed protein expression alterations in cortex, hippocampus and cerebellum of transgenic mice carrying five familial AD mutations (5XFAD) at neonatal day-1. Our results indicate a remarkable difference in protein expression profile of newborn 5XFAD brain with region specific variations. Additionally, the proteins, which show similar expression alteration pattern in postmortem human AD brains, were determined. Bioinformatics analysis showed that the molecular alterations were mostly related to the cell morphology, cellular assembly and organization, and neuroinflammation. Moreover, morphological analysis revealed that there is an increase in neurite number of 5XFAD mouse neurons in vitro. We suggest that, molecular alterations in the AD brain exist even at birth, and perhaps the disease is silenced until older ages when the brain becomes vulnerable

The Effect of Diabetes Camp on Glycemic Variability in Children and Adolescents with Type 1 Diabetes Mellitus

Aim: Glycemic variability can be affected in diabetes camps as a result of sports, social activities and nutrition. Close glucose monitoring is necessary to reduce glycemic variability, especially hypoglycemia. The aim assessment of glycemic variability and time in range by use of the flash glucose monitoring system (FGMS) in children and adolescents with type 1 diabetes. Materials and Methods: Thirty-three children and adolescents between 10-18 years of age who participated in the 2018 diabetes camp of Ege University were included. Their glycemic variability indexes were recorded. Results: The mean age and duration of diabetes mellitus in the study group was 13.3 +/- 0.5 and 4.9 +/- 0.7 years respectively. Twelve (43%) of the participants were boys and 16 (57%) were girls. Ten (35.7%) of the participants used continuous subcutaneous insulin infusion (CSII) pump therapy while 18 (64.3%) used multiple dose insulin therapy. When the participants were evaluated according to time in range (TIR), the duration of TIR increased, and level 1 and level 2 hyperglycemia decreased during the camp. Participants using CSII had spent more time in level 2 hypoglycemia before camp, but during and after the camp, similar values were reached for both groups. Before the camp, participants with good metabolic control had a longer duration of hypoglycemia than those participants with poor metabolic control. During and after the camp, level 1 and level 2 hypoglycemia periods were similar between the two groups. Conclusion: In diabetes camp, healthy diet, regular exercise, and close glycemic control improve glycemic variability. By using FGMS, normoglycemia periods can be increased without increasing hypoglycemic attacks. As a result, using FGMS had a positive effect on diabetes management and the control of hypoglycemia periods during the diabetes camp

Proteomics analysis of CA1 region of the hippocampus in pre-, progression and pathological stages in a mouse model of the alzheimer’s disease

Background: CA1 subregion of the hippocampal formation is one of the primarily affected structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this region. Objective: In this study, we aimed to identify the protein expression alterations throughout the pre-pathological, progression and pathological stages of AD mouse model. Methods: The CA1 region perfusates were collected by in-vivo intracerebral push-pull perfusion from transgenic 5XFAD mice and their non-transgenic littermates at 3, 6 and 12 wereΒmonths of age. Morris water maze test and immunohistochemistry staining of A performed to determine the stages of the disease in this mouse model. The protein expression differences were analyzed by label-free shotgun proteomics analysis. Results: A total of 251, 213 and 238 proteins were identified in samples obtained from CA1 regions of mice at 3, 6 and 12 months of age, respectively. Of these, 68, 41 and 33 proteins showed statistical significance. Pathway analysis based on the unique and common proteins within the groups revealed that several pathways are dysregulated during different stages of AD. The alterations in glucose and lipid metabolisms respectively in pre-pathologic and progression stages of the disease, lead to imbalances in ROS production via diminished SOD level and impairment of neuronal integrity. Conclusion: We conclude that CA1 region-specific proteomic analysis of hippocampal degeneration may be useful in identifying the earliest as well as progressional changes that are associated with Alzheimer’s disease