Binary Properties from Cepheid Radial Velocities (CRaV)

We have examined high accuracy radial velocities of Cepheids to determine the binary frequency. The data are largely from the CORAVEL spectrophotometer and the Moscow version, with a typical uncertainty of $\leq1$~km~s$^{-1}$, and a time span from 1 to 20 years. A systemic velocity was obtained by removing the pulsation component using a high order Fourier series. From this data we have developed a list of stars showing no orbital velocity larger than $\pm1$~km~s$^{-1}$. The binary fraction was analyzed as a function of magnitude, and yields an apparent decrease in this fraction for fainter stars. We interpret this as incompleteness at fainter magnitudes, and derive the preferred binary fraction of $29\pm8$\% ( $20\pm6$\% per decade of orbital period) from the brightest 40 stars. Comparison of this fraction in this period range (1-20 years) implies a large fraction for the full period range. This is reasonable in that the high accuracy velocities are sensitive to the longer periods and smaller orbital velocity amplitudes in the period range sampled here. Thus the Cepheid velocity sample provides a sensitive detection in the period range between short period spectroscopic binaries and resolved companions. The recent identification of $\delta$ Cep as a binary with very low amplitude and high eccentricity underscores the fact that the binary fractions we derive are lower limits, to which other low amplitude systems will probably be added. The mass ratio (q) distribution derived from ultraviolet observations of the secondary is consistent with a flat distribution for the applicable period range (1 to 20 years).Comment: accepted for publication in A

SPION@polydehydroalanine hybrid particles

It is generally accepted that a protein corona is rapidly formed upon exposure of nanoparticles to biological fluids and that both the amount and the composition of adsorbed proteins affect the dispersion properties of the resulting particles. Hereby, the net charge and overall charge density of the pristine nanoparticles are supposed to play a crucial role. In an attempt to control both charge and charge distribution, we report on the coating of superparamagnetic iron oxide nanoparticles (SPIONs) with different polyelectrolytes. Starting from orthogonally protected polydehydroalanine, the material can be easily transformed into a polyanion (poly(tert-butoxycarbonyl acrylic acid), PtBAA), polycation (poly(aminomethylacrylate), PAMA), or even a polyzwitterion (polydehydroalanine, PDha). While coating of SPIONs with PtBAA and PDha was shown to be successful, approaches using PAMA have failed so far. The dispersion properties of the resulting hybrid particles have been investigated using dynamic light scattering (DLS), zeta-potential, and TEM measurements – the amount of adsorbed polymer was quantified using vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA)

YSOVAR: Mid-infrared Variability among YSOs in the Star Formation Region Serpens South

We present a time-variability study of young stellar objects (YSOs) in the Serpens South cluster performed at 3.6 and 4.5 μm with the Spitzer Space Telescope; this study is part of the Young Stellar Object VARiability project. We have collected light curves for more than 1500 sources, including 85 cluster members, over 38 days. This includes 44 class I sources, 19 sources with flat spectral energy distributions (SEDs), 17 class II sources, and five diskless YSO candidates. We find a high variability fraction among embedded cluster members of ~70%, whereas young stars without a detectable disk display no variability. We detect periodic variability for 32 sources with periods primarily in the range of 0.2–14 days and a subset of fast rotators thought to be field binaries. The timescale for brightness changes are shortest for stars with the most photospheric SEDs and longest for those with flat or rising SEDs. While most variable YSOs become redder when fainter, as would be expected from variable extinction, about 10% get bluer as they get fainter. One source, SSTYSV J183006.13−020108.0, exhibits "cyclical" color changes

X-Ray Observations of the Peculiar Cepheid V473 Lyr Identify A Low-mass Companion

V473 Lyr is a classical Cepheid which is unique in having substantial amplitude variations with a period of approximately 3.3 years, thought to be similar to the Blazhko variations in RR Lyrae stars. We obtained an {\it XMM-Newton} observation of this star to followup a previous detection in X-rays. Rather than the X-ray burst and rapid decline near maximum radius seen in $\delta$ Cephei itself, the X-ray flux in V473 Lyr remained constant for a third of the pulsation cycle covered by the observation. Thus the X-rays are most probably not produced by the changes around the pulsation cycle. The X-ray spectrum is soft (kT = 0.6 keV), with X-ray properties which are consistent with a young low mass companion. Previously there was no evidence of a companion in radial velocities or in {\it Gaia} and {\it Hipparcos} proper motions. While this rules out companions which are very close or very distant, a binary companion at a separation between 30 and 300 AU is possible. This is an example of an X-ray observation revealing evidence of a low mass companion, which is important in completing the mass ratio statistics of binary Cepheids. Furthermore, the detection of a young X-ray bright companion is a further indication that the Cepheid (primary) is a Population I star, even though its pulsation behavior differs from other classical Cepheids.Comment: Accepted by A

COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future