46 research outputs found

    Diagnostic utility of snail in metaplastic breast carcinoma

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    Metaplastic breast carcinoma (MBC) is a rare subtype of breast cancer characterized by coexistence of carcinomatous and sarcomatous components. Snail is a nuclear transcription factor incriminated in the transition of epithelial to mesenchymal differentiation of breast cancer. Aberrant Snail expression results in lost expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. We aimed to identify the utility of Snail, and of traditional immunohistochemical markers, in accurate MBC classification and to evaluate clinicopathologic characteristics and outcome

    Dental management long term follow-up of the post radio-chemotherapy-Rhabdomyosarcoma patient: Report of a case

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    Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood and adolescence involving the head and neck. It occurs most often in the head and neck region, genitourinary tract, retroperitoneum and the extremities. The current treatment of a combination of surgery, chemotherapy and radiotherapy has dramatically improved the long term survival rates over the last 20 years. However, some of the side effects of post-radiation include delayed eruption of teeth, retarded tooth and bone development, dwarfed teeth, partial anadontia, osteoradionecrosis, xerostomia, mucositis, candidiasis, trismus, loss of taste, soft tissue necrosis, and scar tissue formation. RMS is a comparatively rare lesion for the maxillofacial surgeons. Although documented to be the most common soft tissue sarcoma in children under 15 years of age, there is, however, a paucity of reports on the pattern of the late effects of multimodal treatment results about intra-oral involvement. This case report focused on the dental treatment and facial abnormalities in a long-term survivor of pediatric head and neck RMS patient and review of the literature. © 2012

    Shrinkage estimation for dose-response modeling in phase II trials with multiple subgroups

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    Mathematical modelling of convection drying characteristics of artichoke (Cynara scolymus L.) leaves [Enginar yapraklarının (Cynara scolymus L.) konveksiyonel kuruma karakteristiklerinin matematiksel modellenmesi]

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    This paper presents the results of a study on mathematical modelling of convection drying of artichoke (Cynara scolymus L.) leaves. Artichoke leaves used for drying experiments were picked from the agricultural faculty experimentation fields on the campus area of Ege University. Chopped artichoke leaves were then used in the drying experiments performed in the laboratory at different air temperatures (40, 50, 60 and 70 °C) and airflow velocities (0.6, 0.9 and 1.2 m s-1) at constant relative humidity of 15±2%. Drying of artichoke leaves down to 10% wet based moisture content at air temperatures of 40, 50, 60 and 70 °C lasted about 4.08, 2.29, 1.32 and 0.98 h respectively at a constant drying air velocity of 0.6 m s-1 while drying at an air velocity of 0.9 ms-1 took about 3.83, 1.60, 0.96 and 0.75 h. Increasing the drying air velocity up to 1.2 m s-1 at air temperatures of 40, 50, 60 and 70 °C reduced the drying time down to 3.5, 1.54, 1.04 and 0.71 h respectively. Different mathematical drying models published in the literature were used to compare based on the coefficient of multiple determination (R2), root mean square error (RMSE), reduced chi-square (?2) and relative deviation modulus (P). From the study conducted, it was concluded that the Midilli et al drying model could satisfactorily explain convection drying of artichoke (Cynara scolymus L.) leaves under the conditions studied. © Ankara Üniversitesi Ziraat Fakültesi

    The weathering characteristics of Ankara andesites from the rock mechanics point of view

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    The weathering characteristics of Ankara andesites and their importance from the rock mechanics point of view are studied. First, a review of processes involved with the weathering of rocks is presented together with the engineering implications and available methods of describing and classifying the products for engineering purposes. The latest universal weathering grade rock mass classifying system developed by Dearman and his friends is used for the field studies of the research. A detailed investigation on the physico-mechanical properties of the weathered Ankara andesites is carried out in the laboratory and their relations with each other are studied. Mohr envelopes have been established for each weathering grade of different andesite types. The general trend of Mohr envelopes for weathered andesitic rock shows that Mohr envelope lines can be drawn to represent the each weathering grade. There is systematic decrease in the values of material constants with the degree of weathering

    Experimental investigation of cooling performance of milk cooling tank with the vapor compressed and solar absorption (LiCl-H2O) cooling system [Süt sogutma tankinin buhar sikiştirmali ve güneş enerjili absorpsiyonlu (LiCl-H2O) sogutma sistemleriyle sogutma performansinin deneysel incelenmesi]

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    In this study, utilization of a solar energy powered absorption cooling system has been investigated instead of conventional cooling systems for milk cooling purpose as an alternative method. In this study, a novel designed milk tank (1000 liter tank capacity and 2BII performance class) with rollbond type heat exchanger around the wall and conventional heat exchanger bottom of the tank for vapor compression cooling system was used. Performance investigation of the tank has been realized while the first and last milking experiments according to International and National Standards for the milk storage tank. Experimental studies have been realized for the hybrid combination of the conventional (vapor compression) cooling and the LiCl-H2O absorption cooling systems with an internal energy storage ability. According to experiments, the conventional and absorption cooling method were cooled down the milk at the first milking period in the reasonable time interval. On the other hand, while the conventional method was being completed in the reasonable time interval, hybrid method was not able to complete in accepted time limit. Utilization of the hybrid combination of the LiCl-H2O absorption and conventional cooling system showed 18.01 Wh/L specific energy consumption, but conventional cooling system showed 21.06 Wh/L specific energy consumption at the same cooling amount. In Turkey, utilization of solar and geothermal energy powered absorption cooling systems to increase energy savings in different cooling application can be significant method since Turkey has advantages about renewable energy sources such as solar and geothermal energy
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