Sutureless Aortic Valve Replacement – the First Experience in Trakya University

DergiPark: 378995tmsjIntroduction: We present the first experience of sutureless aortic bioprosthesis valve replacement in Trakya University Cardiovascular Surgery Clinic. Case report:A 71 year-old female patient with shortness of breath admitted to the cardiology clinic. In physical examination, there was a 3/6 systolic murmur on aortic area spreading to the neck. In the echocardiography, severe aortic stenosis and mild aortic insufficiency was found. In coronary angiography, 90% stenosis was found on proximal portion of left anterior descending coronary artery. Aortic valve replacement and coronary artery by-pass operation was planned. Results: The first sutureless aortic valve replacement in Trakya University Hospital was performed successfully and the patient was discharged from the hospital without any complication

Evaluating the Prevalence of Depression, Sleep Quality and Social Phobia Among Trakya University Hospital Residents

DergiPark: 379051tmsjAims: The purpose of this study is to determine and evaluate the depression, sleep quality and social anxiety levels among medical residents at Trakya University Hospital.Methods: This questionnaire study was conducted among 105 voluntary medical residents at Trakya University Hospital. Beck Depression Inventory, Pitssburgh Sleep Quality Index and Liebowitz Social Anxiety Scale was used to assess depression, sleep quality and social phobia. As for statistical analyses, chi-square, Kruskal Wallis and Mann Whitney Tests were used for analyzing categorical and continuous data.Results: It was found out that 39% of them had depressive symptoms ranging from “mild depressive” to “very severe depressive”, when 14.3% had poor sleep quality and 87.6% had social anxiety symptoms ranging from “moderate social anxiety” to “very severe social anxiety”. Beck Depression Score for surgical residents was significantly higher than basic sciences residents, when female residents had a significantly higher score for social anxiety in comparison with male residents.Conclusion: The prevalence of depression, poor sleep quality and social anxiety among residents was found to be higher than expected which might be due to stress, heavy workload and lifestyle of physician

Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia

Despite increasing survival rates of pediatric leukemia patients over the past decades, the outcome of some leukemia subtypes has remained dismal. Drug sensitivity and resistance testing on patient-derived leukemia samples provide important information to tailor treatments for high-risk patients. However, currently used well-based drug screening platforms have limitations in predicting the effects of prodrugs, a class of therapeutics that require metabolic activation to become effective. To address this issue, a microphysiological drug-testing platform is developed that enables co-culturing of patient-derived leukemia cells, human bone marrow mesenchymal stromal cells, and human liver microtissues within the same microfluidic platform. This platform also enables to control the physical interaction between the diverse cell types. Herein, it is made possible to recapitulate hepatic prodrug activation of ifosfamide in their platform, which is very difficult in traditional well-based assays. By testing the susceptibility of primary patient-derived leukemia samples to the prodrug ifosfamide, sample-specific sensitivities to ifosfamide in primary leukemia samples are identified. The microfluidic platform is found to enable the recapitulation of physiologically relevant conditions and the testing of prodrugs including short-lived and unstable metabolites. The platform holds great potential for clinical translation and precision chemotherapy selection

MEMS gravimetrik tınlaşım esaslı kütle algılayıcıların üretimi için parylene pul bağlama yöntemini esas alan yeni bir üretim akışının geliştirilmesi.

This thesis reports development of a parylene bonding based fabrication method for MEMS gravimetric resonant based mass sensors that are integrated with microfluidics for real-time detection when there is a liquid flow through the microfluidic channels. Parylene bonding has been optimized by conducting several bare bonding experiments. The optimized bonding takes place at 250ºC, in vacuum (1 mTorr) and with 2000 N of vertical piston force for 1 hour. The average shear bonding strength is 15.58 MPa for the optimized bonding recipe. Based on the optimized recipe, a novel method for fabricating lateral gravimetric resonators located on top of a microfluidic channel has been proposed. A previous resonator design has been selected as benchmark, and has been fabricated using the method. The measurements show close agreement with the analytical and FEM results, proving the applicability of the fabrication method. The mass sensitivity of one of the fabricated resonators has been calculated as 5.89 pg/Hz. Attachment of a µ-bead has caused a shift of 150 Hz in the resonance frequency. The mass of the attached µ-bead has been measured as 883.5 pg. Liquid flow tests has shown that there is no liquid leakage neither around the bonding interface nor through the resonator gaps. However, the liquid inside the microfluidic channel has introduced additional feedthrough suppressing the sensing current of the sensor. The resonance characteristics when there is liquid inside the channel could not be extracted by using the differential characterization technique. The models and experimental results prove the potential of the proposed fabrication method for fabricating gravimetric resonant based mass sensors and low temperature integration with microfluidics.  M.S. - Master of Scienc

Prevalance and correlates of self harm behaivors and suicide among bariatric surgery candidates

Amaç: Bu çalışmada bariatrik cerrahi hazırlığında olan hastaların psikiyatrik açıdan değerlendirilmesi, hastaların kendine zarar verme profilleri, intihar düşünce-davranışlarının sıklığının incelenmesi ve bu davranışlarla ilişkili klinik ve sosyodemografik faktörlerin saptanması amaçlanmıştır. Gereç ve Yöntem: Bu çalışma Eylül 2020 – Mayıs 2021 tarihleri arasında Düzce Üniversitesi Tıp Fakültesi'nde Obezite Merkezi tarafından obezite cerrahisi öncesi değerlendirme amacıyla Ruh Sağlığı ve Hastalıkları Anabilim Dalı'na konsültasyonu istenen ardışık tüm vakalar üzerinde yürütülmüştür. Araştırmaya 18 yaş üstü, verilen ölçekleri uygun bir şekilde anlayıp cevaplayabilecek olan hastalardan çalışmaya katılmaya gönüllü olanların tamamı (n=70) dâhil edilmiştir. Her katılımcıyla DSM-V tanı ölçütlerine göre klinik görüşme yapıldıktan sonra Sosyo-Demografik Veri Formu, Kendine Zarar Verme Davranışı Değerlendirme Envanteri (KZVDDE), Columbia İntihar Riskini Derecelendirme Ölçeği (C-SSRS), Yeme Tutumu Testi 40 (YTT-40), Yeme Bozukluğu Değerlendirme Ölçeği (YEDÖ), Hollanda Yeme Davranışı Anketi (DEBQ), Beck Depresyon Ölçeği (BDÖ), Beck Anksiyete Ölçeği (BAÖ) ve Gece Yeme Anketi (GYA) ölçekleri uygulanmıştır. Bulgular: Çalışmaya katılan bariatrik cerrahi adaylarının intihar girişimi öyküsü %2,85 ve C-SSRS'ye göre yaşam boyu intihar düşüncesi bulunma oranı %31,4 olarak bulunmuştur. Katılımcıların 11'inin (%15,7) KZVDDE ölçeğine göre daha önce en az bir yöntemle kendine zarar verdiği belirlenmiştir. C-SSRS'ye göre yaşam boyu intihar düşüncesi olanlarda işsizlik, tıbbi hastalık, BDÖ skoru, YEDÖ total skoru, DEBQ duygusal yeme ve GYA sabah iştahsızlığı alt ölçek ortalama rank değerleri anlamlı derecede yüksek bulunmuştur (sırasıyla p=0.016, p=0.042, p=0.033, p=0.033, p=0.026, p=0.032). Yapılan lojistik regresyon analizinde C-SSRS'ye göre yaşam boyu intihar düşüncesi bulunma odds oranı işsizlerde 6,17 kat, tıbbi hastalığı olanlarda 3,41 kat, yüksek DEBQ duygusal yeme altölçek puanı olanlarda 1,73 kat artmaktadır. Sonuç: Bariatrik cerrahi öncesi değerlendirilen hastalarda intihar girişimi ve yaşam boyu intihar düşüncesi sıktır. Bu hasta gurubunda intihar düşüncesi ve davranışları sorgulanırken, işsizlik, tıbbi hastalık varlığı ve emosyonel yeme durumlarını içeren ayrıntılı değerlendirme yapılmalıdır. Anatar sözcükler: İntihar, kendine zarar verme davranışı, bariatrik cerrahi, obezite, psikopatolojiObjective: In this study, it was aimed to evaluate the patients' self-harm profiles, the frequency of suicidal thoughts-behaviors and to determine the clinical and sociodemographic factors associated with these behaviors by psychiatric evaluation of patients who are preparing for bariatric surgery. Materials and Methods: This study was carried out between September 2020 and May 2021 on all consecutive outpatients that were consulted to the Department of Psychiatry for the purpose of pre-bariatric evaluation by the Obesity Center at Düzce University Faculty of Medicine. All patients (n=70) over the age of 18 who could understand and answer the scales appropriately and volunteered to participate were included in the study. After clinical interview with each participant according to DSM-V diagnostic criteria, Socio-demographic data form, Inventory of Statements About Self-injury (ISAS), Columbia Suicide Severity Rating Scale (C-SSRS), The Eating Attitudes Test 40 (EAT-40), Eating Disorder Examination Questionnaire (EDE-Q), Dutch Eating Behavior Questionnaire (DEBQ), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Night Eating Questionnaire (NEQ) were applied. Results: The rate of suicide attempts of the surgical candidates was 2.85% and the lifetime suicidal ideation rate according to C-SSRS was 31.4%. Acoording to ISAS scores 11 participants (%15,7) had a history of at least one self injury behaviour. According to C-SSRS, in those with lifetime suicidal ideation; unemployment, medical illness, BDI score, EDE-Q total score, DEBQ emotional eating subscale and NEQ morning appetite subscale mean rank values were found to be significantly higher (respectively p=0.016, p=0.042, p=0.033, p=0.033, p=0.026, p=0.032). In the logistic regression analysis; according to the C-SSRS, lifetime suicidal ideation odds ratio increases 6.17 times in the unemployed, 3.41 times in those with a medical illness, and 1.73 times with the increase in the DEBQ emotional eating subscale score. Conclusion: Suicide attempts and life time suicidal thoughts are prevalent among bariatric surgery candidates. According to the results of the research, while suicidal thoughts and behaviors are questioned in patients evaluated before bariatric surgery, a detailed evaluation including unemployment, presence of medical illness and emotional eating should be done. Key Words: Suicide, self-injury, bariatric surgery, obesity, psychopatholog

Special industrial zone structure in Turkey, an example of Deliklikaya Industrial Zone

Kalkınmanın en önemli ana itici gücü sanayidir. Dünyada gelişmiş ve güçlü ekonomilere sahip ülkelerin tamamı güçlü bir sanayi üretim yapısına sahiptir. Güçlü sanayi yapıları konusu ele alındığında karşımıza genel ölçekte Ekonomi Bölgeleri kavramı çıkmaktadır. Ülkemizde birçok farklı formda ekonomi bölgeleri mevcuttur. Araştırmanın konusu olan Özel Endüstri Bölgeleri ise diğer ekonomi bölgelerine nazaran çok daha yeni ve geliştirilmeye açık bir yapılanmadır. Bu araştırmada, ülkemizde rüştünü ispatlamış ve uzun yıllar ülke ekonomisine hizmet etmiş Organize Sanayi Bölgelerinin yerini alabilecek yeni ve yenilikçi bir sanayi yapılanmasının üzerinde çalışılmıştır. Ülkemizde en yaygın şekilde kullanılan Organize Sanayi Bölgeleri ve yeni yapılanma olan Özel Endüstri Bölgeleri benzerlikleri ve farkları araştırılmıştır. Çalışma kapsamında çok parselli Özel Endüstri Bölgelerindeki imar sorunlarına ve çözümlerine odaklanılmıştır. Çalışmanın yönteminde vaka analizi olarak, içerisinde hem Özel Endüstri Bölgesi yapılanmasın hem de sanayi bölgesini ve kooperatif yönetimini barındıran Deliklikaya Sanayi Bölgesi projesi seçilmiştir. Deliklikaya Sanayi Bölgesinde ilan edilen Özel Endüstri Bölgelerinin diğer Endüstri Bölgelerinden farkı çok parselli yapılanmaya sahip olmasıdır. Bu çok parselli yapının ne gibi sorunlar oluşturduğu yahut avantajlarının neler olduğu konularına yanıt aranmıştır. Ayrıca Deliklikaya Sanayi Bölgesinin çevresindeki sanayi bölgeleriyle oluşturacağı sinerji inşaat sektörü için önemlidir. Bu bağlamda Deliklikaya Sanayi Bölgesi hakkında detaylı bir araştırma sunulmuş ve bu veriler sonucunda bölgenin SWOT analizi yapılmıştır. Daha sonra SWOT maddeleri Likert tipi ankete çevrilerek bölgede faaliyet gösteren katılımcılara uygulanmıştır. Seçilen vaka ve anket sonuçlarının Özel Endüstri Bölgelerinin Türkiye'deki yapılanması hakkında bir araştırma hazırlanmış ve sonuç olarak, güçlenmesi gereken özellikleri olsa da Özel Endüstri Bölgesi yapılanmasının, ülke ekonomisine kısa vadede katkı sağlayacağı sonucuna ulaşılmıştır.The most important main driving force of development is industry. All of the countries with developed and strong economies in the world have a strong industrial production structure. When the issue of strong industrial structures is taken into consideration, the concept of Economic Zones emerges on a general scale. There are many different economic zones in our country. Special Industrial Zones, which are the subject of the research, are much newer and open to development compared to other economic zones. In this research, a new and innovative industrial structure that can replace the Organized Industrial Zones that has come of age in our country and has served the country's economy for many years has been studied. The similarities and differences between Organized Industrial Zones, which are the most widely used in our country, and Special Industrial Zones, which are the new structuring, have been investigated. Within the scope of the study, the zoning problems and solutions in the multi-parcel Special Industrial Zones are focused. As a case study in the method of the study, the Deliklikaya Industrial Zone Project (which includes Private Industrial Zone structuring, the industrial zone and the cooperative management) was chosen. The difference of the Special Industrial Zones announced in the Deliklikaya Industrial Zone from the other Industrial Zones is that they have a multi-parcel structure. It has been sought to answer the questions of what kind of problems this multi-parcel structure creates or what its advantages are. In addition, the synergy that Deliklikaya Industrial Zone will create with the surrounding industrial zones is important for the construction sector. In this context, a detailed research on the Deliklikaya Industrial Zone was presented and a SWOT analysis of the region was made as a result of these data. Then, the SWOT items were converted into a Likert type questionnaire and applied to the participants operating in the region. A study has been prepared on the structuring of the Special Industrial Zones in Turkey with the selected case and survey results, and as a result, it has been concluded that the structuring of the Special Industrial Zone will contribute to the country's economy in the short term, even though it has features that need to be strengthened

Characterization and driving method based on the second harmonic, which is enhancing the quality factor and reducing the feedthrough current in varying gap electrostatic MEMS resonators

Başvuru konusu buluş, elektrostatik sürülen değişken boşluklu rezonatörler için yüksek kalite faktörlü ve kaçak akım etkilerinden arındırılmış yeni bir karakterizasyon yöntemi ile ilgilidir.A method of an open loop characterization of an electrostatic MEMS based resonator with a varying gap, the method including: converting, via a trans-impedance amplifier circuit, an output current signal of the resonator into a voltage; multiplying the output current signal converted into the voltage, by means of a multiplier circuit, with an AC signal or with a different signal at a frequency of the resonator and carrying a second harmonic signal to a main tone; and measuring a frequency response of a signal cleared of frequencies apart from the main tone using a network analyzer

What is the future of electrical impedance spectroscopy in flow cytometry?

More than twenty years ago, electrical impedance spectroscopy (EIS) was proposed as a potential characterization method for flow cytometry. As the setup is comparably simple and the method is label-free, EIS has attracted considerable interest from the research community as a potential alternative to standard optical methods, such as fluorescence-activated cell sorting (FACS). However, until today, FACS remains by and large the laboratory standard with highly developed capabilities and broad use in research and clinical settings. Nevertheless, can EIS still provide a complement or alternative to FACS in specific applications? In this perspective, we will give an overview of the current state of the art of EIS in terms of technologies and capabilities. We will then describe recent advances in EIS-based flow cytometry (EIS-FC), compare the performance to that of FACS methods, and discuss potential prospects of EIS in flow cytometry

Türkiye’nin ilk stand-up sanatçısı : Orhan Boran

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Öztürk, İbrahim Mert

Şık Düğme

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Özer, Abdürrahim