Does Post-COVID-19 Erectile Dysfunction Improve over Time?

BACKGROUND Some studies have shown that there may be an increase in the frequency of erectile dysfunction after COVID-19. However, no long-term study has investigated whether this is permanent or temporary. In this study, we aimed to examine whether there was an increase in the frequency of erectile dysfunction among individuals with a history of COVID-19, and, if there was, whether their condition improved over time. MATERIALS AND METHODS In this study, a total of 125 healthy male healthcare workers, 95 with and 30 without a history of COVID-19, were evaluated in terms of erectile function. Four study groups were formed. The first three groups consisted of individuals with a history of COVID-19 confirmed by the polymerase chain reaction (PCR) test at different times, who recovered from the disease (time elapsed since COVID-19 positivity: 12 months for Group 3). The individuals in Group 4 did not have a history of COVID-19 diagnosis. In order to evaluate the erectile function of the participants, they were asked to complete the five-item International Index of Erectile Function questionnaire (IIEF-5). Then, statistical analyses were performed to evaluate whether there was a difference between the groups in terms of the IIEF-5 scores. RESULTS There was a statistically significant difference between the groups in terms of the IIEF-5 scores (p 0.999, p = 0.204, and p = 0.592, respectively). CONCLUSION There may be deterioration in erectile function after COVID-19; however, this tends to improve over time, especially from the first year after active infection. Given that vascular, hormonal, and/or psychogenic factors may lead to the development of erectile dysfunction after COVID-19, we consider that in order to easily manage this process, it is important to determine the underlying cause, initiate appropriate treatment, and inform couples that this situation can be temporary

Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi

Objective:Studies show that in patients diagnosed with Coronavirus disease-2019 (COVID-19), polymerase chain reaction (PCR) tests can give false negative results depending on sampling techniques/regions. In this study; the positivity of virus RNA was studied consecutive lung tru-cut needle biopsy taken at 6-hour intervals in cases who died during treatment due to COVID-19 infection, it was aimed to determine the postmortem safe working range.Methods:In May 2020-April 2021, 21 patients who died during treatment due to COVID-19 infection diagnosed with clinical and/or RNA detection in Muğla Training Research Hospital, Anesthesia Intensive Care Unit were included. Antemortem, postmortem swabs results, and virus RNA detection by PCR made from postmortem lung tissue samples were compared with their clinics. Statistical analysis was performed.Results:Fifteen (71.4%) of 21 cases were male and 6 (28.6%) were female. The mean age is 71.9 (standard deviation=12.079). All of the toracic CT findings at hospitalization had a ground-glass opacity. The mean hospitalization time was 11.7 days. Antemortem nasopharyngeal virus positivity was shown in 13 cases (61.9%), postmortem nasopharyngeal virus positivity in 5 cases (23.8%), and virus positivity in lung tissue samples in 7 cases (33.3%). No significant correlation was found virus positivity in nasopharyngeal swab and lung tissue sample, the incompatibility rate was 19.1%, which was statistically significant.Conclusion:Although the targeted sample size could not be reached due to study limitations, the inconsistency in virus positivity in nasopharyngeal swabs and lung tissue samples is significant. It is certain that studies with a large comparative sample are needed in terms of postmortem survival time, clinical and organ damage caused by the virus

Assessing prognosis with modified early warning score, rapid emergency medicine score and worthing physiological scoring system in patients admitted to intensive care unit from emergency department

Introduction: In this study our purpose is to examine the effectiveness and reliability of MEWS (Modified Early Warning Score), REMS (Rapid Emergency Medicine Score) and WPS (Worthing Physiological Scoring System) scoring systems for prediction of the prognosis and mortality rate of critically ill patients scheduled to be admitted to intensive care unit (ICU) among emergency department (ED) patients. Methods: This single-centered retrospective study was performed on medical, surgical and trauma patients referred to the ED and admitted to ICU of University Hospital between 23 July 2013 and 26 November 2015. Results: Mortality and the duration of stay in ICU were significantly correlated with systolic blood pressure (SBP) and WPS score compared to other variables (p = 0.014, p = 0.010 respectively). The decrease in SBP increased the mortality by 2 (OR: %95 CI 1.1-3.5) fold and the increase in WPS increased the mortality by 2.4 (OR: %95 CI 1.2-4.5) fold. Conclusions: In our study, there was a more significant correlation between WPS score and mortality and duration of stay in ICU compared to other scores

Gebelikte hipertrigliseridemiye bağlı akut pankreatit

WOS:000370842200010PubMed ID: 27366478Gebelik sırasında hypertrigliseridemiye bağlı akut pankreatit nadir fakat hem anne hem de bebek için ölümcül sonuçlara neden olabilen ciddi klinik bir tablodur. Otuz yedi yaşında 31 haftalık familial hypertrigliseridemi ve diabetes mellitusu olan gebede akut pankreatit gelişti. İntrauterin bebek ölümü gelişen hastanın gebeliği sonlandırıldı. Tedavide insülin, octreotidin yanısıra double membrane filtration ile plasmaferez uygulanarak trigliseritlerin hızla düşürülmesi sağlandı. Trigliserid düzeyi 24 saat sonunda 9742 mg dL-1den 432 mg dL-1 düzeyine geriledi. Hasta 5 gün sonra yoğun bakımdan, 32 gün sonra hastaneden sağlıklı olarak taburcu edildi. Bu yazıda gebe vakada ciddi hipertrigliserideminin başarılı tedavisi sunulmuştur.Acute pancreatitis due to hypertriglyceridaemia during pregnancy is a rare but severe clinical condition that may cause fatal results for both the mother and the foetus. Acute pancreatitis developed in a 37-year-old pregnant woman with familial hypertriglyceridaemia and diabetes mellitus in the 31st week of pregnancy. As intrauterine foetal death developed, the pregnancy of the patient was terminated. Additionally, insulin, octreotide and plasmapheresis with double membrane filtration were applied, and triglycerides rapidly decreased. After 24 hours, the level of triglycerides decreased from 9742 mg dL-1 to 432 mg dL-1. The patient was discharged from the intensive care unit at the end of 5 days and was discharged from the hospital after 32 days. The current article presents the successful treatment of severe hypertriglyceridaemia in a pregnant cas

Bispectral Index Guided Sedation in Congenital Pain Insensitivity Syndrome

Konjenital ağrıya duyarsızlık sendromu (KADS); ağrıya duyarsızlık, anhidrozis, ısı intoleransı ve değişik derecelerde mental retardasyon ile birlikte seyreden, yüksek morbiditesi nedeniyle olguların sıklıkla adölesan dönemde hayatlarını kaybettiği nadir görülen bir sendromdur (1). Ağrısız kırıklar, nörojenik artropati (charcot eklemi) ve eklem deformiteleri sık görülmektedir (2). Ağrıya duyarsız olmalarına rağmen bu hastalarda cerrahi işlem boyunca taktil hiperaljezi gibi rahatsız edici durumlar meydana gelebileceğinden genel anestezi veya sedasyon uygulanmalıdır (3). Yeterli sedasyon derinliği bispektral indeks (BİS) monitörizasyonu ile sağlanarak alt ekstremite ameliyatı geçiren KADS olgusununun perioperatif yönetimini literatür eşliğinde tartışmayı amaçladık. Konjenital ağrıya duyarsızlık sendromu nedeniyle pediyatri servisinde takip edilen 10 yaşında ve 36 kg olan hastanın sol dizinde osteomiyelit ve septik artrit gelişmesi nedeniyle ortopedi kliniği tarafından debridman ve abse drenajı planlandı. Bebeklik döneminde dilini ısırma sonucu ağrı duymadığı fark edilerek tanısı konulduğu öğrenildi. Preoperatif değerlendirmede mental retardasyonu, ağrı ve sıcaklığa karşı duyarsızlığı olan hastada, dokunma duyusu ve diğer nörolojik muayenesi normaldi. Hastanın elinde ve parmaklarında kendisinin oluşturduğu yaralanmalar mevcuttu (Şekil 1). Hava yolu değerlendirmesinde ağız açıklığı Mallampati II olarak belirlenirken, laboratuvar değerleri ve akciğer grafisi normaldi. Girişim öncesi dönemde hastanın ebeveynleri uygulanacak anestezi yöntemi hakkında bilgilendirildikten sonra aydınlatılmış yazılı onam alındı. Ameliyathaneye alınan olguya standart monitörizasyon (nabız oksimetresi, elektrokardiyografi, noninvazif arter kan basıncı, sıcaklık takibi) ile birlikte BİS monitörizasyonu (BIS VİSTA Monitoring System, USA) uygulandı

Serum netrin-1 levels in systemic sclerosis patients with capillary abnormalities

Background: Systemic sclerosis (SSc) is a rare, potentially destructive systemic autoimmune disease characterized by organ fibrosis and vasculopathy. Netrin-1 is associated with angiogenesis, inflammation, and apoptosis. Aim of the work: To assess the level of serum netrin-1 in SSc patients with capillary abnormalities and to evaluate its relation to disease manifestations. Patients and methods: This study investigated the relationship between netrin-1 and fibrosis in 56 SSc patients and 58 matched control. The modified Rodnan skin score (mRss) was used to assess skin thickness. Serum netrin-1 level was quantitatively measured using an enzyme-linked immunosorbent assay. Results: The study included 56 patients; 53 females and 3 males (F:M 17.7:1) with a mean age of 48·1 ± 13·6 years and disease duration of 13.01 ± 8·7 years. They were 43 (76.7 %) diffuse and 13 (23.3 %) limited subtypes. The median mRss was 6.58 ± 2.2. Raynaud’s disease was present in 50 % and interstitial lung disease in 57.1 %. The median netrin-1 level was significantly higher in SSc patients (268·8 pg/mL; 82·8-1006·6 pg/mL) than in the controls (108·6 pg/mL;21·02-351·5 pg/mL, p < 0·0001). There was no significant difference in the serum netrin-1 levels in SSc patients with and without Raynaud’s disease (p = 0.55), interstitial lung disease (p = 0.18), anti-Scl70 positive antibodies (p = 0·78), and anti-centromere antibody (p = 0·493). Netrin-1 was significantly related to SSc (OR = 1·02, 95 %CI: 1·01 − 1·03, p < 0·0001). At a cut-off value 126·3 pg/mL, netrin-1 would diagnose SSc (sensitivity 60·3%, specificity 94·6%, 95 %CI: 0·83 − 0·95, p < 0·0001). Conclusion: SSc patients had significantly high levels of serum netrin-1 with a potential role in the pathophysiology of the disease