10 research outputs found
The Poetics of White: Concepts of Greek Antiquity in the Age of the Avant-garde
- Author
- Acosta
- Acosta
- Aurnhammer
- Aurnhammer
- Bell
- Bell
- Benn
- Benn
- Benn
- Benn
- Breccia
- Breccia
- Bredekamp
- Bredekamp
- Carl
- Carl
- Cavafy
- Cavafy
- Dehmel
- Dehmel
- Empereur
- Empereur
- Eva Kocziszky
- Friedrich
- Friedrich
- Gage
- Gage
- Geroulanos
- Geroulanos
- Glenn
- Glenn
- Goll
- Goll
- Goll
- Goll
- Goll
- Goll
- Green
- Green
- Göhler
- Göhler
- Hans
- Hans
- Hermann Wagner
- Hermann Wagner
- Heselhaus
- Heselhaus
- Homeyer
- Homeyer
- Horae
- Horae
- Kerényi
- Kerényi
- Kiesel
- Kiesel
- Klaus
- Klaus
- Larnaudie
- Larnaudie
- Malevich
- Malevich
- Malevich
- Malevich
- Miller
- Miller
- Mösch
- Mösch
- Nagy
- Nagy
- Peter Lang
- Peter Lang
- Prater
- Prater
- Roilos
- Roilos
- Souter
- Souter
- Turowski
- Turowski
- Winckelmann
- Winckelmann
- Wood
- Wood
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- Field of study
11. Quellen und Literatur
- Author
- Adler
- Ankwicz-Kleehoven Hans
- Baader
- Bearb Peter Hans
- Bonjour Edgar
- Brieskorn Norbert
- Campbell Donald
- Chmel Joseph
- Co van de Kieft Jan Frederik
- Czeike
- Czeike
- Denifle Heinrich
- Denis Michael
- der Reichsstadt Das Medizinalwesen
- Dotation Zur
- Ebendorfer Thomas
- Exzerpte Stamser
- Fahlenbock Michaela
- Faustmann Cornelia
- Firnhaber Friedrich
- Flieder Viktor
- Gall
- Gall
- Geschichte der Wiener Universität Zur Quellenlage
- Girgensohn
- Glassner Christine
- Gloria Andrea
- Gottlieb
- Graf
- Göhler Hermann
- Herschel Karl Adolph
- Hierszmann Hans
- Hollegger
- Holzer Bürgermeister
- Hormayr Joseph
- Horn
- Hovorka
- Keussen Hermann
- Keussen Hermann
- Kleineidam Erich
- Klemm Hermann
- Kos Wolfgang
- Krick Ludwig Heinrich
- Lackner
- Lackner
- Lackner
- Lang Alois
- Lenzenweger
- Mazal
- Mediziner Gelehrte
- Melchers
- Mühlberger
- Mühlberger Kurt
- Müller-Bütow Horst
- Namhafte Männer
- Opll Ferdinand
- Ortvay Theodor
- Pagel Julius-Leopold
- Perger
- Pohl-Resl
- Pongratz
- Pribram Alfred Francis
- Professoren Österreicher
- Puschmann
- Puschmann Theodor
- Regiomontans Zeit
- Reichard
- Rexroth Frank
- Ritter Gerhard
- Rosas
- Rupprich Hans
- Rupprich Hans
- Rüegg
- Sablik
- Schipperges
- Schrauf
- Schrauf
- Schrauf
- Schönbauer
- Senfelder
- Senfelder
- Siraisi
- Stangler
- Stossier Harald
- Sudhoff
- Tersch
- Thorbecke August
- Ubl Karl
- Uhlirz Karl
- Uiblein
- Uiblein
- Uiblein
- Uiblein
- Uiblein
- Universitätsarchiv Wiener
- Universitätsbibliothek Die
- Unterkircher
- Vasold Manfred
- von Carolsfeld Franz Schnorr
- von Ebengreuth Luschin
- von Ellingen Georg Läntsch
- von Lichnowsky Eduard Maria
- von Robert
- von Sevilla Isidor
- Wankmüller Armin
- Werner E.
- Weyermann Albrecht
- Wickersheimer Ernest
- Wien Die Universität
- Wiesflecker Hermann
- Winkler Günther
- Wohlmuth Josef
- Wr Spitalsarzt
- Wurzbach
- Zanesco Alexander
- Zinner Ernst
- Zschokke Hermann
- zur Frühgeschichte Beiträge
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Weltkultur – Zur Aufnahme des Nibelungenliedes in das Weltdokumentenerbe der UNESCO
- Author
- Ashworth Gregory J
- Ashworth Gregory J
- Badische Landesbibliothek
- Badische Landesbibliothek Karlsruhe
- Bartsch Karl
- Bayerische Staatsbibliothek
- Bayerische Staatsbibliothek München
- Bayerische Staatsbibliothek München
- Bendix Bizer
- Brüggen Bayerische Staatsbibliothek
- Brüggen Elke
- Brüggen Holznagel
- Bumke
- Bumke Joachim
- Bumke Joachim
- De Boor Helmut
- Deck Monika
- den Konvention
- Düwel Klaus
- Ebenbauer Alfred
- Ebenbauer Keller
- Edmondson Ray
- Ehrismann Otfrid
- Ehrismann Otfrid
- Formulierung
- FranÅois Schulze
- Genzmer Felix
- Genzmer Felix
- Gephart Irmgard
- Gillespie George T
- Göhler Peter
- Haug Walter
- Haug Walter
- Hegel
- Heinzle Joachim
- Heinzle Joachim
- Hemme Tauschek
- Henkel Nikolaus
- Henkel Nikolaus
- Heusler Andreas
- Hoffmann Werner
- Klein Klaus
- Krause Arnulf
- Krause Arnulf
- Kuhn Hans
- Küpper Joachim
- Lachmann Karl
- Mertens Volker
- Mertens Volker
- Metze-Mangold Verena
- Müller Gernot Michael
- Müller Jan-Dirk
- Müller Jan-Dirk
- München Dr.
- Quast Bruno
- Reichert Hermann
- Schulze Ursula
- Schulze Ursula
- Schulze Ursula
- Schulze Ursula
- Schulze Ursula
- Schulze Ursula
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- UNESCO
- Vgl
- Vgl
- Vgl
- Vgl Nominierungsformular
- Vgl Nominierungsformular
- Vgl Nominierungsformular
- Vgl Nominierungsformular
- Vgl S.
- Vgl S.
- Vgl S.
- Weigelt Frank AndrØ
- Wenzel Horst
- Wolf Alois
- Wolf Alois
- Wyss Ulrich
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Literaturverzeichnis
- Author
- Aber Adolf
- Adorno Theodor W
- Altenburg Detlev
- Aus Italien" Komponisten
- Aus München Neue
- Bahr Hermann
- Batka Richard
- Batka Richard
- Batka Richard
- Bekker Paul
- Bermbach Udo
- Beurtheilungen
- Bie Oscar
- Bloch Ernst
- Brosche Günter
- Brosche Günter
- Brosche Günter
- Brust Fritz
- Buths Don
- Bülow
- Cooke Mervyn
- Dillmann Alexander
- Draeseke Felix
- Edelmann Bernd
- Eybl Martin
- Fiedler Rudolf
- Friedrich Julius
- Fröhlich
- Gabriele Strauss
- Gehring Egid
- Geleitwort zu Leopold Schmidt
- Gilliam Bryan
- Grasberger Franz
- Göhler Georg
- Hamann Brigitte
- Hanslick Eduard
- Hanslick Eduard
- Hanslick Eduard
- Hausegger
- Hausegger Dr.
- Heinemann Michael
- Heister Hanns Werner
- Hernried Robert
- Hoffmann Rudolf Stephan
- Hottmann Katharina
- Hába Alois
- Intermezzo
- Istel Edgar
- Joseph Gregor
- Karpath Ludwig
- Kater Michael
- Keezer Kilian
- Kennedy Michael
- Kistler Cyrill
- Klatte Wilhelm
- Klee Ernst
- Kopsch Julius
- Krause Ernst
- Krienitz Willy
- Költzsch Hans
- Kühn Oswald
- Kühn Oswald
- Kühn Oswald
- Lachenmann
- Leibnitz Thomas
- Lessmann Otto
- Lessmann Otto
- Lessmann Otto
- Lessmann Otto
- Lodes Birgit
- Louis Rudolf
- Mann Thomas
- Marsop Paul
- Mauke Wilhelm
- May Jürgen
- Messmer Franzpeter
- Mittheilungen
- Mittheilungen
- Monika Reger
- Moos Paul
- Neitzel Otto
- Neval K. R.
- Nietzsche Friedrich
- Notizheften des Meisters
- Nüll Richard Strauß
- Ott Alfons
- Peterson Barbara A
- Pringsheim Heinz
- Reger Max
- Rettich Adolf
- Riemann Hugo
- Riemann Hugo
- Ritter A. -r.
- Rolland Romain
- Rolland Romain
- Sandberger Wolfgang
- Schaefer Hartmut
- Schaefer Hartmut
- Scherber Ferdinand
- Schering Arnold
- Schlötterer-Traimer Roswitha
- Schmid Brigitta Maria
- Schmidt Leopold
- Schrenk Walter
- Schuh Willi
- Schuh Willi
- Schuh Willi
- Schuh Willi
- Schuh Willi
- Schwers Paul
- Shigihara Susanne
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Spanuth August
- Specht Richard
- Specht Richard
- Specht Richard
- Specht Richard
- Stefan P. Stf.
- Stefan Paul
- Steinitzer Alfred
- Steinitzer Max
- Steinitzer Max
- Steinitzer Max
- Steinitzer Max
- Steinitzer Max
- Steinitzer Max
- Storck Karl
- Storck Karl
- Storck Karl
- Storck Karl
- Tenschert Roland
- Tenschert Roland
- Tenschert Roland
- Tessmer Hans
- Th Z.
- Tonkünstlerversammlung des Allgemein
- Trenner Florian
- Trenner Franz
- Trenner Franz
- Trenner Franz
- Vogel Bernhard
- Vorwort
- Walden Herwarth
- Walter Michael
- Waltershausen Hermann
- Weill Kurt
- Weißmann Adolf
- Werbeck Walter
- Werbeck Walter
- Westphal Kurt
- Wilhelm Kurt
- Wilhelm Kurt
- Willi Schuh
- Windt Herbert
- Wymetal Die Wiener
- Wymetal Richard Strauß
- Zedler
- Zentner Wilhelm
- Ziegler
- Zweig Stefan
- Publication venue
- 'Boehlau Verlag Ges.m.b.H. & Co. KG'
- Publication date
- Field of study
Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial
- Author
- Aalborg Syd
- Acosta Boris Raul
- Aegidius Karen
- Albiker Christian
- Alegiani Anna
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Aniculaesei Adriana
- Appleton Jason
- Arenillas Juan
- Bardutzky Jürgen
- Baronnet-Chauvet Flore
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan
- Beck Christoph
- Benoit Amandine
- Berhoune Nadia
- Bindila Daniela
- Birchenall Julia
- Blanc-Lasserre Karine
- Bobinger Tobias
- Bodechtel Ulf
- Bodiguel Eric
- Bojaryn Urszula
- Bonnet Anne-Laure
- Bonnet Louise
- Bouamra Benjamin
- Bourgeois Paul
- Boutitie Florent
- Breuer Lorenz
- Breynaert Ludovic
- Broughton David
- Brouns Raf
- Brugirard Sébastian
- Bruneel Bart
- Buggle Florian
- Bähr Christian
- Cakmak Serkan
- Calleja Ana
- Calvet David
- Carrera David
- Chen Hsin-Chieh
- Cheng Bastian
- Cheripelli Bharath
- Cho Tae-Hee
- Choe Chi-Un
- Choy Lillian
- Christensen Hanne
- Ciatipis Mareva
- Cloud Geoffrey
- Cogez Julien
- Cortijo Elisa
- Crozier Sophie
- Damgaard Dorte
- Dani Krishna
- de Coene Beatrijs
- de Hollander Isabel
- de Klippel Nina
- de la Ossa Natalia Pérez
- de Maeseneire Charlotte
- de Morales Noelia Ruiz
- de Smedt Ann
- Dekeyser Jacques
- Deltour Sandrine
- Demeestere Jelle
- Derex Laurent
- Desfontaines Philippe
- Dittrich Ralf
- Dixit Anand
- Dobbels Laurens
- Domigo Valérie
- Dorado Laura
- Druart Charlotte
- Dupont Kristina Hougaard
- Dusart Anne
- Dziewas Rainer
- Ebinger Martin
- Ebner Matthias
- Edjali-Goujon Myriam
- Eisele Philipp
- Elhfnawy Ahmed
- Endres Matthias
- Esperón Carlos García
- Etexberria Ana
- Evans Nicholas
- Fandler Simon
- Fazekas Franz
- Felix Sandra
- Fiebach Jochen
- Fiehler Jens
- Filipov Alexandra
- Filipski Katharina
- Fleischmann Robert
- Foerch Christian
- Gaenslen Alexandra
- Galinovic Ivana
- Gancedo Elena Meseguer
- Ganeshan Ramanan
- Garrido Alicia
- Gattringer Thomas
- Geraghty Olivia
- Geran Rohat
- Gerloff Christian
- Gerner Stefan
- Godon-Hardy Sylvie
- Golsari Amir
- Gomis Meritxell
- Gonzales Miguel Blanco
- Gorriz David
- Gramse Verena
- Grau Laia
- Griebe Martin
- Guerrero Cristina
- Guerzoglu Damla
- Guettier Sophie
- Guillamon Olga Belchí
- Guiraud Vincent
- Gumbinger Christoph
- Gunreben Ignaz
- Göhler Jos
- Haertig Florian
- Hametner Christian
- Hanseeuw Bernard
- Hansen Andreas
- Hansen Jakob
- Harbo Thomas
- Harloff Andreas
- Harmel Peter
- Heinen Florian
- Held Valentin
- Hellwig Simon
- Hemelsoet Dimitri
- Hennerici Michael
- Herm Juliane
- Hermans Sylvia
- Hernández María
- Hjort Niels
- Hobeanu Cristina
- Hobohm Carsten
- Hohenbichler Katharina
- Hoppe Julia
- Hornberger Eva
- Hoyer Carolin
- Huang Xuya
- Höfner Elmar
- Ipsen Nils
- Isern Irina
- Ispierto Lourdes
- Iversen Helle
- Izaga Mikel Terceno
- Jeppesen Lise
- Jimenez Marta
- Jungehülsing Jan
- Jüttler Eric
- Kalladka Dheeraj
- Kallmünzer Bernd
- Kar Arindam
- Kellert Lars
- Kessler Tobias
- Khan Usman
- Klein Matthias
- Kleinschnitz Christoph
- Klockziem Matti
- Knops Michael
- Koehler Luzie
- Koehrmann Martin
- Kohlfürst Heinz
- Kollmar Rainer
- Kraft Peter
- Krause Thomas
- Kröber Jan
- Kurka Natalia
- Ladoux Alexandre
- Laloux Patrice
- Lamy Catherine
- Landrault Emmanuelle
- Lauer Arne
- Leal Joaquin Serena
- Lebely Claire
- Leempoel Jonathan
- Leger Anne
- Legrand Laurence
- Lemmens Robin
- Li Lin
- London Frederic
- Lopez-Cancio Elena
- Lorenz Matthias
- Louw Stephen
- Lovelock Caroline
- Lucente Giuseppe
- Luna Alain
- Löbbe Anna-Mareike
- Lückl Janos
- Macha Kosmas
- Machet Alexandre
- Mackenrodt Daniel
- Madzar Dominik
- Majoie Charles
- Maqueda Vicky
- Mar Castellanos Rodrigo Maria Del
- Marstrand Jacob
- Martinez Alicia
- Marzina Annika
- Mechthouff Laura
- Meden Per
- Meersman Guy
- Meier Julia
- Mellerio Charles
- Menn Oliver
- Meyer Nadja
- Michalski Dominik
- Michels Peter
- Michelsen Lene
- Minnerup Jens
- Modrau Boris
- Morel Nathalie
- Moreton Fiona
- Morin Ludovic
- Moulin Thierry
- Moynihan Barry
- Mueller Anne
- Muir Keith
- Mulero Patricia
- Mundiyanapurath Sibu
- Mutzenbach Johannes
- Männer Anika
- Møller Anette
- Nagel Simon
- Naggara Oliver
- Nallasivan Arumugam
- Navalpotro Irene
- Nave Alexander
- Nederkoorn Paul
- Neugebauer Hermann
- Neumann- Haefelin Tobias
- Nickel Alina
- Nighoghossian Norbert
- Oberndorfer Stefan
- Opherk Christian
- Oppel Lorenz
- Oppenheim Catherine
- Orthgieß Johannes
- Ostergaard Leif
- Palomeras Ernest
- Panitz Verena
- Patel Bhavni
- Pedraza Salvador
- Peeters Andre
- Peeters Dirk
- Pellisé Anna
- Pelz Johann
- Pereira Anthony
- Perry Richard
- Peysson Stéphane
- Pfeilschifter Waltraud
- Pichler Alexander
- Pierskalla Alexandra
- Pledl Hans-Werner
- Poli Sven
- Pomrehn Katrin
- Poulsen Marika
- Prats Luis
- Presas Silvia
- Prohaska Elisabeth
- Puetz Volker
- Puig Josep
- Purrucker Jan
- Quenardelle Veronique
- Ramachandran Sankaranarayanan
- Raphaelle Soulliard
- Raposo Nicolas
- Reiff Tilman
- Remmers Michel
- Renou Pauline
- Ribitsch Martin
- Richter Hardy
- Ringleb Peter
- Ritter Martin
- Ritzenthaler Thomas
- Rodier Gilles
- Rodriguez-Regent Christine
- Rodríguez-Yáñez Manuel
- Roennefarth Maria
- Roffe Christine
- Rosenbaum Sverre
- Rosso Charlotte
- Rozanski Michal
- Russo Francesca
- Rutgers Matthieu
- Röther Joachim
- Sagnier Sharmilla
- Samson Yves
- Sauer Tamara
- Schieber Simon
- Schill Josef
- Schlak Dennis
- Schlemm Ludwig
- Schmidt Sein
- Schonewille Wouter
- Schröder Julian
- Schulz Andreas
- Schurig Johannes
- Schwarting Sönke
- Schwarz Alexander
- Schwarzbach Christopher
- Schäfer Jan
- Seidel Matthias
- Seiler Alexander
- Sembill Jochen
- Shetty Ashit
- Sibon Igor
- Simonsen Claus
- Singer Oliver
- Sivagnanaratham Aravinth
- Smets Ide
- Smith Craig
- Soors Peter
- Sprigg Nikola
- Spruegel Maximilian
- Stark David
- Steinert Susanne
- Stuermlinger Markus
- Stösser Sebastian
- Swinnen Bart
- Sygehus Aalborg
- Sánchez Josep
- Sánchez Manuel Lozano
- Tamazyan Ruben
- Tawil Salwa El
- Tembl Jose
- Thijs Vincent
- Thomalla Götz
- Torne Monica Millán
- Touze Emmanuel
- Touzé Emmanuel
- Truelsen Thomas
- Turc Guillaume
- Turine Gaetane
- Tyrell Pippa
- Tütüncü Serdar
- Ustrell Xavier
- Vadot Wilfried
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- van Hooff Robbert- Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Vicente Jose Hervas
- Viguier Alain
- Vilas Dolores
- Voget Dieke
- von Schrader Jörg
- von Weitzel Paul
- Warburton Elisabeth
- Weber Claudia
- Weber Jörg
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weise Christopher
- Weise Gesa
- Willems Chris
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wouters Anke
- Yalo Bertrand
- Yger Marion
- Younan Nadia
- Yperzeele Laetita
- Zegarac Vesna
- Zeiner Pia
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- American Heart Association
- Publication date
- 01/01/2020
- Field of study
International audienceBackground and Purpose— Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial), intravenous alteplase was effective in patients with unknown onset stroke selected by visual assessment of diffusion weighted imaging fluid-attenuated inversion recovery mismatch, that is, in those with no marked fluid-attenuated inversion recovery hyperintensity in the region of the acute diffusion weighted imaging lesion. In this post hoc analysis, we investigated whether quantitatively measured FLAIR-rSI modifies treatment effect of intravenous alteplase. Methods— FLAIR-rSI of stroke lesions was measured relative to signal intensity in a mirrored region in the contralesional hemisphere. The relationship between FLAIR-rSI and treatment effect on functional outcome assessed by the modified Rankin Scale (mRS) after 90 days was analyzed by binary logistic regression using different end points, that is, favorable outcome defined as mRS score of 0 to 1, independent outcome defined as mRS score of 0 to 2, ordinal analysis of mRS scores (shift analysis). All models were adjusted for National Institutes of Health Stroke Scale at symptom onset and stroke lesion volume. Results— FLAIR-rSI was successfully quantified in stroke lesions in 433 patients (86% of 503 patients included in WAKE-UP). Mean FLAIR-rSI was 1.06 (SD, 0.09). Interaction of FLAIR-rSI and treatment effect was not significant for mRS score of 0 to 1 ( P =0.169) and shift analysis ( P =0.086) but reached significance for mRS score of 0 to 2 ( P =0.004). We observed a smooth continuing trend of decreasing treatment effects in relation to clinical end points with increasing FLAIR-rSI. Conclusions— In patients in whom no marked parenchymal fluid-attenuated inversion recovery hyperintensity was detected by visual judgement in the WAKE-UP trial, higher FLAIR-rSI of diffusion weighted imaging lesions was associated with decreased treatment effects of intravenous thrombolysis. This parallels the known association of treatment effect and elapsing time of stroke onset
Quellen- und Literaturverzeichnis
- Author
- Adam Thomas
- Albrecht Friedrich
- Albrecht Willy
- Altner Helmut
- Aly Götz
- Annie
- Arnold Heinz Ludwig
- Ash Mitchell G
- Assmann Frevert
- Aufbau Kulturpolitische Monatsschrift
- Baerns Barbara
- Bautz Friedrich
- Bayer
- Becker Thomas
- Behal Michael
- Beilecke FranÅois
- Bentley James
- Benz Scholz
- Benz Wolfgang
- Bernhardi Horst
- Bernhardt Markus
- Bernsdorf Knospe
- Beyme
- Birkert Alexandra
- Bleek Wilhelm
- Bleuel Hans Peter
- Boch Ralph
- Bock
- Bockel Asendorf
- Bodenstein Walter
- Bollenbeck Georg
- Bollenbeck Knobloch
- Boockmann Göttingen
- Bourdieu Pierre
- Boyens Armin
- Braun Birgit
- Braun Gerhardt
- Brelie-Lewien
- Brelie-Lewien
- Briegleb Klaus
- Broszat Schwabe
- Bruch
- Bruch
- Bruch
- Brunck Helma
- Brunner Koselleck
- Bröckling Ulrich
- Brück
- Bungenstab
- Busch Eberhard
- Bussiek Dagmar
- Carl
- Charle Christophe
- Cheval RenØ
- Chroust Peter
- Clark
- Clemens Gabriele
- Coing Helmut
- Conze Eckart
- Conze Kocka
- Cramer Ernst
- Dahrendorf Ortlieb
- Dahrendorf Ralf
- Das Goldene Tor
- Der Bund Jahrbuch
- Der Ruf
- Der Spiegel
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- Ders Vergangenheitspolitik
- Deutsche Rundschau Berlin
- Diers Andreas
- Dies
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- Dies Maskenwechsel
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- ür Zeitgeschichte
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
- Author
- Aarnio K.
- Acosta Boris Raul
- Aegidius Karen
- Akutsu Tsugio
- Albiker Christian
- Alegiani Anna
- Alemseged F.
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Althaus-Knaurer Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Anderson C.
- Ang T.
- Aniculaesei Adriana
- Aoki Junya
- Appleton Jason
- Arakawa Shuji
- Archer M. L.
- Arenillas Juan
- Attia J.
- Back Christina
- Bailey P.
- Balabanski A.
- Barber A.
- Barber P. A.
- Bardutzky J. rgen
- Baronnet-Chauvet Flore
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan L.
- Beck Christoph
- Belchí Guillamon Olga
- Bendszus Martin
- Benoit Amandine
- Berhoune Nadia
- Bernhardt J.
- Berrouschot J. rg
- Betensky Rebecca A.
- Bindila Daniela
- Birchenall Julia
- Bivard A.
- Blacker D.
- Bladin C. F.
- Bladin Christopher F.
- Blanc-Lasserre Karine
- Blanco Gonzales Miguel
- Bluhmki Erich
- Bobinger Tobias
- Bodechtel Ulf
- Bodiguel Eric
- Bojaryn Urszula
- Bonnet Louise
- Bouamra Benjamin
- Boulouis Gregoire
- Bourgeois Paul
- Boutitie Florent
- Bovi Paolo
- Breuer Lorenz
- Breynaert Ludovic
- Brodtmann A.
- Broughton David
- Brouns Raf
- Brugirard S. bastian
- Bruneel Bart
- Buggle Florian
- Bähr Christian
- Cadilhac D.
- Cakmak Serkan
- Calleja Ana
- Calvet David
- Campbell B. C. V.
- Campbell Bruce C. V.
- Carandang Raphael A.
- Carey L.
- Carrera David
- Celestino S.
- Chan L.
- Chang W. H.
- ChangI A.
- Chatellier Gilles
- Chen C. H.
- Chen C. I.
- Chen H. F.
- Chen Hsin-Chieh
- Chen T. C.
- Chen W. H.
- Chen Y. Y.
- Cheng Bastian
- Cheng C. A.
- Cheong E.
- Cheripelli Bharath
- Chiou Y. W.
- Cho Tae-Hee
- Choe Chi-un
- Choi P. M.
- Choy Lillian
- Christensen Hanne
- Chu H. J.
- Chuang C. S.
- Chung T. C.
- Churilov L.
- Churilov Leonid
- Ciatipis Mareva
- Clissold B.
- Cloud Geoffrey
- Cogez Julien
- Connelly A.
- Coote S.
- Copen William A.
- Cortijo Elisa
- Cougo Pedro
- Coulton B.
- Cove Lynda
- Cowley E.
- Cranefield J.
- Crozier Sophie
- Curtze S.
- Cutting Shawna
- D'Este C.
- Damgaard Dorte
- Dani Krishna
- Davis S. M.
- Davis Stephen
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- Day S.
- de Coene Beatrijs
- de Hollander Isabel
- de Keyser Jacques
- de Klippel Nina
- de Maeseneire Charlotte
- de Smedt Ann
- del Mar Castellanos Rodrigo Maria
- Deltour Sandrine
- Demeestere Jelle
- Derex Laurent
- Desfontaines Philippe
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- Domigo Valérie
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- Donnan Geoffrey
- Donnan Geoffrey A.
- Dorado Laura
- Drake Kendra
- Drew R.
- Druart Charlotte
- Dupont Kristina Hougaard
- Dusart Anne
- Dziewas Rainer
- Ebinger Martin
- Ebner Matthias
- Edjali-Goujon Myriam
- Egashira Yusuke
- Ehrenkrona Christina
- Eirola S.
- Eisele Philipp
- el Tawil Salwa
- Elhfnawy Ahmed
- Endres Matthias
- Enomoto Yukiko
- Eschenfelder Christoph
- Etexberria Ana
- Evans Nicholas
- Fandler Simon
- Fatar Marc
- Fazekas Franz
- Felix Sandra
- Fiebach Jochen B.
- Fiebach Jochen B.
- Fiehler Jens
- Field D.
- Filipov Alexandra
- Filipski Katharina
- Fleischmann Robert
- Foerch Christian
- Ford Andria L.
- Ford Ian
- Francisco Arenillas Juan
- Frost T.
- Fukuda-Doi Mayumi
- Furui Eisuke
- Furuta Konosuke
- Gaenslen Alexandra
- Galinovic Ivana
- Gancedo Elena Meseguer
- Ganeshan Ramanan
- Garcia-Esperon C.
- García Esperón Carlos
- Garrido Alicia
- Gattringer Thomas
- George K.
- Geraghty Olivia
- Geran Rohat
- Gerloff Christian
- Gerner Stefan
- Gerraty R.
- Godon-Hardy Sylvie
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- Gomis Meritxell
- Gorriz David
- Gotoh Seiji
- Gramse Verena
- Grau Laia
- Griebe Martin
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- Gruber Franz
- Guerrero Cristina
- Guerzoglu Damla
- Guettier Sophie
- Guiraud Vincent
- Gumbinger Christoph
- Gunreben Ignaz
- Guo Y. C.
- Göhler Jos
- Hacke Werner
- Haertig Florian
- Hallenbeck John
- Hamasaki Toshimitsu
- Hametner Christian
- Hankey G.
- Hanseeuw Bernard
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- Harbo Thomas
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- Harmel Peter
- Harris Gordon J.
- Harvey J.
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- Heinen Florian
- Held Valentin
- Hellwig Simon
- Hemelsoet Dimitri
- Hennerici Michael
- Herm Juliane
- Hermans Sylvia
- Hernández María
- Hervas Vicente Jose
- Hirano Teryuki
- Hjort Niels
- Ho S. C.
- Hobeanu Cristina
- Hobohm Carsten
- Hoesch Robert
- Hogan K.
- Hohenbichler Katharina
- Homma Kazunari
- Hommel Marc
- Hoppe Julia
- Hornberger Eva
- Howells D.
- Hoyer Carolin
- Hsia Amie
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- Hu C. J.
- Huang C. C.
- Huang H. Y.
- Huang M. Y.
- Huang S. C.
- Huang W. S.
- Huang Xuya
- Häusler Karl Georg
- Höfner Elmar
- Ichijyo Masahiko
- Ide Toshihiro
- Igarashi Shuichi
- Iguchi Yasuyuki
- Ihara Masafumi
- Ikenouchi Hajime
- Inoue Manabu
- Inoue Tsuyoshi
- Ipsen Nils
- Isern Irina
- Ispierto Lourdes
- Itabashi Ryo
- Ito Yasuhiro
- Iversen Helle
- Iwama Toru
- Jackson D.
- Jeng J. S.
- Jeppesen Lise
- Jiang S. K.
- Jimenez Marta
- Jungehülsing Jan
- Jüttler Eric
- Kaauwai L.
- Kala Lalit
- Kalladka Dheeraj
- Kallmünzer Bernd
- Kamiyama Kenji
- Kamiyoshi Shoko
- Kanai Haruka
- Kanematsu Yasuhisa
- Kanzawa Takao
- Kapeller Peter
- Kar Arindam
- Kasari O.
- Kase Carlos
- Kaste Markku
- Kellert Lars
- Kemmling André
- Kessler Christof
- Kessler Tobias
- Khan Usman
- Kimura Kazumi
- King J.
- Kitayama Jiro
- Kitazono Takanari
- Klein Matthias
- Kleinig T. J.
- Kleinig Timothy J.
- Kleinschnitz Christoph
- Klockziem Matti
- Knops Michael
- Koehler Luzie
- Koehrmann Martin
- Koga Masatoshi
- Kohlfürst Heinz
- Koivu M.
- Kolbe J.
- Kollmar Rainer
- Kondo Rei
- Kraft Peter
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- Krause Thomas
- Kristensen Bo
- Kröber Jan M.
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- Kudo Kohsuke
- Kung W. L.
- Kurka Natalia
- Kusumi Masayoshi
- Kuwahara Ken
- Kyndt C.
- Köhrmann Martin
- Laage Rico
- Ladoux Alexandre
- Laloux Patrice
- Lamy Catherine
- Landrault Emmanuelle
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- Lovelock Caroline
- Low E.
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- Machet Alexandre
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- Mackey E.
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- Mahadevan J.
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- Marstrand Jacob
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- Marzina Annika
- Mas Jean-Louis
- Matsumoto Shoji
- Matsuoka Hideki
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- Meden Per
- Meersman Guy
- Meier Julia
- Mellerio Charles
- Menn Oliver
- Meretoja A.
- Meyer Nadja
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- Michels Peter
- Michelsen Lene
- Mihara Ban
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- Mishra S.
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- Moreton Fiona
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- Moulin Thierry
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- Mueller Anne K.
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- Muir Keith W.
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- Muller C.
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- Muzikansky Alona
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- Nagaraja Nandakumar
- Nagel Simon
- Naggara Oliver
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- Poli Sven
- Pomrehn Katrin
- Poulsen Marika
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- Puig Josep
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- Quenardelle Veronique
- Ramachandran Sankaranarayanan
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- Raposo Nicolas
- Reiff Tilman
- Remmers Michel
- Renou Pauline
- Ribitsch Martin
- Richter Hardy
- Ringleb Peter
- Ritter Martin
- Ritzenthaler Thomas
- Rodier Gilles
- Rodrigues E.
- Rodriguez-Regent Christine
- Rodríguez-Yáñez Manuel
- Roennefarth Maria
- Roffe Christine
- Rosenbaum Sverre
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- Ueda Toshihiro
- Uesaka Yoshikazu
- Uotani Mihoko
- Urabe Takao
- Ustrell Xavier
- Vadot Wilfried
- Vallat W.
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- van Hooff Robbert-Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Viguier Alain
- Vilas Dolores
- Villringer Kersten
- Virta J.
- Voget Dieke
- von Kummer R. diger
- von Schrader J. rg
- von Weitzel Paul
- Wahlgren Nils
- Wang W. C.
- Wang Y. T.
- Warach Steven
- Warburton Elisabeth
- Wardlaw Joanna
- Watanabe Masao
- Waters M.
- Weber Claudia
- Weber J. rg
- Wegscheider Karl
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weir L.
- Weise Christopher
- Weise Gesa
- Wijeratne T.
- Willems Chris
- Williams C.
- Wilson W.
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wong A. A.
- Wong K.
- Wouters Anke
- Wu Ona
- Wu T. Y.
- Wu Y. H.
- Yagita Yoshiki
- Yakushiji Yusuke
- Yalo Bertrand
- Yamamoto Haruko
- Yan B.
- Yang F. C.
- Yang Y. W.
- Yassi N.
- Yassi Nawaf
- Yasui Keizo
- Yeh H. L.
- Yeh J. H.
- Yeh S. J.
- Yen C. H.
- Yger Marion
- Yonehara Toshiro
- Yoo Albert J.
- Yoshimura Shinichi
- Yoshimura Sohei
- Younan Nadia
- Young D.
- Yperzeele Laetita
- Ysai C. L.
- Zand Ramin
- Zegarac Vesna
- Zeiner Pia
- Zhang W. W.
- Zhao H.
- Zhao L.
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- 'Elsevier BV'
- Publication date
- 14/11/2020
- Field of study
Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I 2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None
Leichenerscheinungen und Todeszeitbestimmung
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- A Albrecht
- A Brand
- A Brown
- A Devergie
- A Franchini
- A Haberda
- A Haberda
- A Haberda
- A Hagge
- A Hase
- A Himmelreich
- A Klein
- A Klein
- A Klein
- A Klein
- A Klein
- A Klein
- A Klein
- A Kussmaul
- A Kussmaul
- A Kölliker
- A Lindström
- A Orsös
- A Peterson
- A Ponsold
- A Schackwitz
- A Schramm
- A Schulz
- A Simon
- A Sorge
- A Szent-Gyorgyi
- A Vain
- A Werkgartner
- AA Hassan
- AC Jaffe
- AEA Joseph
- AG Kuklinka
- AG Wintle
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- AH Mckeown
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- AK Behrensmeyer
- AK Mant
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- AL Rosales
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- AT Schäfer
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- B Forster
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study