Genetic and molecular characterization of nitric oxide homeostasis (NO) during early plant development in Arabidopsis thaliana

[ES]El desarrollo vegetal se caracteriza por su extrema plasticidad, permitiendo incluso la pérdida de órganos en plantas adultas, ya que su naturaleza autotrófica requiere de grandes superficies que impiden el movimiento. Esta habilidad es posible gracias a la integración de los diversos estímulos ambientales en una compleja red de señalización que converge en la regulación de la división y diferenciación celular. Las estructuras vegetales que gobiernan estos procesos se conocen como meristemos, y contienen células totipotentes que permiten un crecimiento continuo a lo largo de la vida de la planta. Dos meristemos principales dan lugar a todos los órganos vegetales, el meristemo apical del tallo (SAM, por sus siglas en inglés, shoot apical meristem), que produce la parte aérea, y el meristemo apical de la raíz (RAM, root apical meristem), que genera la raíz primaria y controla la arquitectura radicular

Aplicación móvil FC-RED propuesta digital para cuidadores de adolescentes con trastornos de alimentación

El presente Trabajo de Fin de Grado (TFG) nace de la necesidad de empoderar a los cuidadores de pacientes diagnosticados de Trastorno de la Conducta Alimentaria (TCA) con herramientas que faciliten el proceso de recuperación y protección de los pacientes. Para lograr este objetivo, se pretende aprovechar las ventajas del medio digital. Tras un estudio de mercado de las soluciones existentes, se concluyó la existencia un hueco de oportunidad para una aplicación móvil (APP). Con el fin de validar la necesidad y la utilidad de la solución, se ha procedido al desarrollo de un prototipo funcional. La herramienta se ha organizado en tres módulos en función del contenido: psicoeducación, estrategias prácticas y grupo de autoayuda. Se presenta un proyecto con el que se pretende abordar el malestar psicológico y emocional que puede desencadenar esta situación para dichos cuidadores por medio de la adquisición de conocimientos sobre la enfermedad y ciertas habilidades para afrontar distintos ámbitos del procedimiento. Asimismo, recibirán apoyo psicológico de profesionales y sesiones de motivación con la participación de otros cuidadores. La meta final consiste en incrementar la calidad de vida de los cuidadores y, por consiguiente, de los pacientes, para así favorecer su tratamiento. Se pretende, de esta manera, reducir los tiempos de recuperación y aumentar efectividad del tratamiento del TCA.The current Final Degree Project (FDP) arises from the need to empower caregivers of patients diagnosed with an Eating Disorder (ED) with certain tools facilitating the treatment process and the protection of these patients. To achive this goal, we expect to levarage the advantages of digital environmets. Having assessed the market for existing and competing solutions, we concluded the existence of a market gap, translating into an opportunity for a mobile application (or APP). With the goal of validating the need and the proposed solution, a functional prototype has been developed. The tool has been organized around three modules based on the content: psychoeducation, practical strategies and self-help groups. This project aims to tackle the psychological and emotional discomfort that can be caused by the situation these caregivers face. In this way, this is carried out by compiling information about the disease, as well as showing the required skills to cope with certain scopes of the procedures regarding the treatment of the disease. Likewise, caregivers will receive psychological support coming from professionals and motivation through profession colleagues’ real-life experiences. The ultimate goal to be achieved by this project is to improve the caregivers’ life quality and, therefore, to transfer the same impact onto that of their patients. This would ultimately reduce the disorder’s recovery time and increase the effectiveness of the TCA treatment.Psicologí

Use of Mel Frequency Cepstral Coefficients for Automatic Pathology Detection on Sustained Vowel Phonations: Mathematical and Statistical Justification

This paper presents a justification for the use of MFCC parameters in automatic pathology detection on speech. While such an application has produced good results up to now, only partial explanations to this good performance had been given before. The herein exposed explanation consists of an interpretation of the mathematical transformations involved in MFCC calculation and a statistical analysis that confirms the conclusions drawn from the theoretical reasoning

Citocromo P-450 extrahepático

Citocromo P-450 extrahepático

Las ómicas en el desarrollo de nuevos fármacos

Las ómicas en el desarrollo de nuevos fármacos

Screening voice disorders with the glottal to noise excitation ratio

This work evaluates the capabilities of the Glottal to Noise Excitation Ratio for the screening of voice disorders. A lot of effort has been made using this parameter to evaluate voice quality, but there do not exist studies that evaluate the discrimination capabilities of this acoustic parameter to classify between normal and pathological voices. A set of 226 speakers (53 normal and 173 pathological) taken from a voice disorders database were used to evaluate the usefulness of this parameter for discriminating normal and pathological voices. In order to evaluate this parameter, the effect of the bandwidth of the Hilbert envelopes and the frequency shift have been analyzed, concluding that a good discrimination is obtained with a bandwidth of 1000 Hz and a frequency shift of 300 Hz. The results confirm that the Glottal to Noise Excitation Ratio provides reliable measurements in terms of discrimination among normal and pathological voices, comparable to other classical long-term noise measurements found in the literature, such as Normalized Noise Energy or Harmonics to Noise Ratio, so this parameter is a good candidate to be used for screening purposes

Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

AbstractRecombinant human IL-6 (rhIL-6) is a potent inducer of the synthesis of acute phase proteins in adult human hepatocytes. A wide spectrum of acute phase proteins is regulated by this mediator. After labeling of rhIL-6 stimulated human hepatocytes with [35S]methionine acute phase protein synthesis was measured by immunoprecipitation. Serum amyloid A, C-reactive protein, haptoglobin, α1-antichymotrypsin and fibrinogen were strongly induced (26-, 23-, 8.6-, 4.6- and 3.8-fold increases, respectively). Moderate increases were found for α1-antitrypsin (2.7-fold) and α1-acid glycoprotein (2.7-fold). RhIL-6 had no effect on α1-macroglobulin, whereas fibronectin, albumin and transferrin decreased to 64, 56 and 55% of controls. In the cases of serum amyloid A, haptoglobin, α1-antichymotrypsin, α1-antitrypsin and α1-acid glycoprotein, dexamethasone enhanced the action of rhIL-6. We conclude that rhIL-6 controls the acute phase response in human liver cells

Inserción laboral de los graduados de la carrera de Nutrición y Salud Comunitaria de la Universidad Técnica Del Norte, periodo 2014 - 2018: Labor insertion of the graduates of the Carrera de Nutrición y Salud Comunitaria of the Universidad Técnica del Norte, periodo 2014 - 2018a, 2016

This study responds to the requirements established by the Ley Orgánica de Educación Superior (LOES), the objective was to follow up on the graduates of the Career of Nutrition and Community Health of the UTN, period January 2014 - April 2018. Regarding the methodology, was a descriptive, quantitative-qualitative, cross-sectional study. The population, 460 graduates who, through probabilistic sampling, had a participation of 80 graduates. A face-to-face, electronic or telephone survey was applied. The results indicate that 82% of the graduates belong to the female sex, a mixed race ethnic group with 86%. Regarding job placement, 66% work; As for the time to find the first job, it was less than 6 months with 45%. Regarding satisfaction with the academic training received at the UTN, only 22% reported that it was of little use. On the other hand, thequality of teachers, their theoretical foundation, training in practices, availability of time and methodologies used in learning were classified analogously on a scale of good and very good. Only 3% of the study population is conducting postgraduate studies. In conclusion, 2 out of 3 graduates work in their profession. Most rate the knowledge, skills, and abilities acquired in the undergraduate as good and very good.Este estudio responde a los requisitos establecidos por la Ley Orgánica de Educación Superior, LOES, por lo cual el objetivo  fue realizar el seguimiento a los graduados de la Carrera de Nutrición y Salud Comunitaria de la UTN, periodo enero 2014 - abril 2018. Investigación de tipo descriptiva, cuanti-cualitativa, transversal; población de 460 graduados que mediante muestreo probabilístico se obtuvo una muestra de 80; en los cuales se aplicó una encuesta presencial, electrónica y por teléfono. Los resultados indican que el 82% de los graduados pertenece al sexo femenino, etnia mestiza con el 86%. Respecto a la inserción laboral el 66% trabaja; en cuanto al tiempo para encontrar el primer empleo fue menor a 6 meses con 45%. Respecto a la satisfacción con la formación académica recibida en la UTN sólo el 22% refirió que fue poco útil. Por otra parte, la calidad de docentes, su fundamentación teórica, formación en prácticas, disponibilidad de tiempo y metodologías utilizadas en el aprendizaje fueron catalogadas de manera análoga en forma buena y muy buena. Sin embargo, las tres últimas no superaron el 75% en la escala de buena y muy buena. Sólo el 3% de población de estudio se encuentra realizando estudios de posgrado. En conclusión 2 de cada 3 graduados trabajan en su profesión; califican como bueno y muy bueno a los conocimientos, habilidades y destrezas adquiridas en el pregrado

Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

AbstractThe three monokines interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL-6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e. synthesis and secretion of C-reactive protein, serum amyloid A, fibrinogen, α1-antitrypsin, α1-antichymotrypsin and haptoglobin are increased while albumin, transferrin and fibronectin are decreased. IL-1β as well as TNFα, although having a moderate effect on the positive acute phase proteins and inhibiting the synthesis of fibrinogen, albumin and transferrin, fail to induce serum amyloid A and C-reactive protein. These data suggest that IL-6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes