Flavored Non-Minimal Left-Right Symmetric Model Fermion Masses and Mixings

A complete study on the fermion masses and flavor mixing is presented in a non-minimal left-right symmetric model (NMLRMS) where the ${\bf S}_{3}\otimes {\bf Z}_{2}\otimes {\bf Z}^{e}_{2}$ flavor symmetry drives the Yukawa couplings. In the quark sector, the mass matrices possess a kind of the generalized Fritzsch textures that allow us to fit the CKM mixing matrix in good agreement to the last experimental data. In the lepton sector, on the other hand, a soft breaking of the $\mu\leftrightarrow \tau$ symmetry provides a non zero and non maximal reactor and atmospheric angles, respectively. The inverted and degenerate hierarchy are favored in the model where a set of free parameters is found to be consistent with the current neutrino data.Comment: 23 pages, 9 figures. references added, typos corrected, JCGI added his current institution;conclusions rewrote and unchanged results. Version published in European Physical Journal

Inteligencia Artificial en Medicina y Salud: revisión y clasificación de las aplicaciones actuales y del futuro cercano y su impacto ético y social

This paper provides an overview of the current and near-future applications of Artificial Intelligence (AI) in Medicine and Health Care and presents a classification according to their ethical and societal aspects, potential benefits and pitfalls, and issues that can be considered controversial and are not deeply discussed in the literature. This work is based on an analysis of the state of the art of research and technology, including existing software, personal monitoring devices, genetic tests and editing tools, personalized digital models, online platforms, augmented reality devices, and surgical and companion robotics. Motivated by our review, we present and describe the notion of “extended personalized medicine”, we then review existing applications of AI in medicine and healthcare and explore the public perception of medical AI systems, and how they show, simultaneously, extraordinary opportunities and drawbacks that even question fundamental medical concepts. Many of these topics coincide with urgent priorities recently defined by the World Health Organization for the coming decade. In addition, we study the transformations of the roles of doctors and patients in an age of ubiquitous information, identify the risk of a division of Medicine into “fake-based”, “patient-generated”, and “scientifically tailored”, and draw the attention of some aspects that need further thorough analysis and public debate

Tolerancia a diferentes factores antinutritivos en lechones alimentados con guisantes de invierno (Pisum sativum) y alberjón (Vicia narbonensis) en la fase estárter

Se realizaron dos ensayos para evaluar el efecto de dietas con diferentes niveles de factores antinutritivos: inhibidores de tripsina y quimotripsina (UTI, UQI respectivamente, como unidades) de guisantes de invierno y ¿Glutamyl-S-Ethenyl-Cysteine de alberjón, en el rendimiento de lechones durante el periodo estárter. En cada uno se utilizaron 192 machos castrados, híbridos Duroc x (Large-White x Landrace), con 11,23 y 11,55 kg de peso medio respectivamente, e igual diseño: cuatro tratamientos y ocho réplicas cada una de seis lechones. Los tratamientos del Ensayo 1 fueron: Control: harina de soja 47 y soja extrusionada (0,97 UTI-1,94 UQI/mg de pienso); P-CAR: soja extrusionada y guisante Cartouche (1,62 UTI-3,16 UQI/mg de pienso); P-ICE: soja extrusionada y guisante Iceberg (3,09 UTI-4,95 UQI/mg de pienso); P-LUN: soja extrusionada y guisante Luna (3,19 UTI-5,56 UQI/mg de pienso). Los lechones del tratamiento P-CAR crecieron significativamente más que el resto, con igual consumo y conversión. No hubo diferencias entre Control, P-ICE y P-LUN. El pienso del Ensayo 2 incluía diferentes niveles de alberjón: 0%, 5%, 15% y 25%, y en consecuencia de ¿Glutamyl-S-Ethenyl-Cysteine (1,52% del grano). Los lechones del tratamiento 5% comieron y crecieron más, con igual conversión que los del tratamiento 0%. El rendimiento empeoró con porcentajes del 15% o mayores. Se concluye que lechones de 40 a 61 días de vida mantienen o mejoran el rendimiento con la ingesta de inhibidores de proteasas que exceden 3,28 y 2,86 veces, UTI y UQI respectivamente, los de una dieta de soja, y que la inclusión de 5% de alberjón en el pienso aumenta el consumo y el crecimiento. Two trials were conducted to evaluate the effect of diets with different levels of anti-nutritional factors: trypsin (TIU) and chymotrypsin (CIU) inhibitors units of peas and ¿Glutamyl-S-Ethenyl-Cysteine (GEC) of narbon vetch, in productive performance of pigs from 40 to 61 days of age. 192 barrows were used in each test, Duroc hybrid x (Large White x Landrace), with 11.23 and 11.55 kg body weight respectively, and the same experimental design: four treatments and eight replicates with six piglets in each case. In trial 1 treatments were: Control: soybean meal 47 and soybean extruded (0.97 TIU-1.94 CIU/mg feed); P-CAR: soybean extruded and pea Cartouche (1.62 TIU-3.16 CIU/mg feed); P-ICE: soybean extruded and pea Iceberg (3.09 TIU-4.95 CIU/mg feed); P-LUN: soybean extruded and pea Luna (3.19 TIU-5.56 CIU/mg feed). The piglets of P-CAR treatment grew significantly faster than the others, with the same intake and feed conversion. No significant differences between Control, P-ICE and P-LUN. In trial 2 the feedstuff had different levels of narbon vetch: 0%, 5%, 15% and 25%, and consequently of ¿Glutamyl-S-Ethenyl-Cysteine (1.52% of the grain). The piglets that consumed the treatment of 5% had higher intake and growth, and the same conversion that piglets feeding with the treatment of 0%. The performance worsened significantly with increasing 15%. We conclude that piglets in starter period maintain or improve the performance with intake of proteases inhibitors in feedstuff that exceed 3.28 (TIU) and 2.86 (CIU) times those of a control diet, and that the inclusion of 5% of narbon vetch in feedstuff increases feed intake and growth

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant women and have a higher risk of adverse pregnancy outcomes like intrauterine/fetal distress and preterm birth. However, little is known about the impact of SARS-CoV-2 infection on maternal and neonatal immunological profiles. In this study, we investigated the inflammatory and humoral responses to SARS-CoV-2 in maternal and cord blood paired samples. Thirty-six pregnant women were recruited at delivery at Hospital Sant Joan de Déu, Barcelona, Spain, between April-August 2020, before having COVID-19 available vaccines. Maternal and pregnancy variables, as well as perinatal outcomes, were recorded in questionnaires. Nasopharyngeal swabs and maternal and cord blood samples were collected for SARS-CoV-2 detection by rRT-PCR and serology, respectively. We measured IgM, IgG and IgA levels to 6 SARS-CoV-2 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length and C-terminus), IgG to N from 4 human coronaviruses (OC43, HKU1, 229E and NL63), and the concentrations of 30 cytokines, chemokines and growth factors by Luminex. Mothers were classified as infected or non-infected based on the rRT-PCR and serology results. Sixty-four % of pregnant women were infected with SARS-CoV-2 (positive by rRT-PCR during the third trimester and/or serology just after delivery). None of the newborns tested positive for rRT-PCR. SARS-CoV-2 infected mothers had increased levels of virus-specific antibodies and several cytokines. Those with symptoms had higher cytokine levels. IFN-? was increased in cord blood from infected mothers, and in cord blood of symptomatic mothers, EGF, FGF, IL-17 and IL-15 were increased, whereas RANTES was decreased. Maternal IgG and cytokine levels showed positive correlations with their counterparts in cord blood. rRT-PCR positive mothers showed lower transfer of SARS-CoV-2-specific IgGs, with a stronger effect when infection was closer to delivery. SARS-CoV-2 infected mothers carrying a male fetus had higher antibody levels and higher EGF, IL-15 and IL-7 concentrations. Our results show that SARS-CoV-2 infection during the third trimester of pregnancy induces a robust antibody and cytokine response at delivery and causes a significant reduction of the SARS-CoV-2-specific IgGs transplacental transfer, with a stronger negative effect when the infection is closer to delivery.Copyright © 2022 Rubio, Aguilar, Bustamante, Muñoz, Vázquez-Santiago, Santano, Vidal, Melero, Parras, Serra, Santamaria, Carolis, Izquierdo, Gómez-Roig, Dobaño, Moncunill and Mazarico

Analysis of remarkable bolides observed between June and July 2022 in the framework of the Southwestern EuropeMeteor Network

Some of the bright bolides spotted in the framework of the Southwestern Europe Meteor Network from June to July 2022 are discussed here. These were observed from Spain. Their absolute magnitude ranges from –6 to –11. Fireballs included in this work were generated by different sources: the sporadic background, major meteoroid streams, and poorly known streams.Spanish Ministry of Science and Innovation (project PID2019-105797GB-I00). State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). Spanish grant AYA - RTI2018 – 098657 – J - I00 “LEO-SBNAF” (MCIU / AEI / FEDER, UE)

Analysis of bright bolides recorded between October and November 2022 by the Southwestern Europe Meteor Network

We present in this work the analysis of some of the bright fireballs spotted in the framework of the Southwestern Europe Meteor Network (SWEMN) between October and November 2022. They have been observed from the Iberian Peninsula and had a maximum brightness ranging from mag. –7 to mag. –15. Most meteors included in this report were linked to the sporadic background and also to the Southern Taurids.Spanish Ministry of Science and Innovation (project PID2019-105797GB-I00). State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). Spanish grant AYA -RTI2018–098657–J-I00 “LEO-SBNAF” (MCIU / AEI / FEDER, UE)

Remarkable fireballs spotted in the framework of the Southwestern Europe Meteor Network along August and September 2022

Some of the bright bolides observed in the framework of the Southwestern Europe Meteor Network between August and September 2022 are described in this work. These have been spotted from the Iberian Peninsula. Their maximum luminosity ranges from mag. –7 to mag. –12. One of these bolides gave rise to a meteorite.Spanish Ministry of Science and Innovation (project PID2019-105797GB-I00). Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709).Spanish grant AYA - RTI2018 – 098657 -J- I00 “LEO-SBNAF” (MCIU / AEI / FEDER, UE)

The Southwestern Europe Meteor Network: notable meteors spotted between December 2022 and January 2023

We present in this report the analysis of some of the notable meteors registered in the framework of the Southwestern Europe Meteor Network between December 2022 and January 2023. These were recorded from Spain. Their peak brightness ranges from mag. –7 to mag. –10. The emission spectrum of one of them is also presented. Bright meteors included here were produced by different sources: the sporadic background, major meteoroid streams, and poorly-known streams.Spanish Ministry of Science and Innovation (project PID2019-105797GB-I00). State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). Spanish grant AYA - RTI2018 – 098657 – J - I00 “LEO – SBNAF” (MCIU / AEI / FEDER, UE)