Lost in Space? Reconstructing Frank Willett’s excavations at Ita Yemoo, Ile-Ife, Nigeria: Rescue Excavations (1957–1958) and Trench XIV (1962–1963)Lost in Space? Reconstructing Frank Willett’s excavations at Ita Yemoo, Ile-Ife, Nigeria: Rescue Excavations (1957–1958) and Trench XIV (1962–1963)

From December 1957 to January 1958, Frank Willett conducted a “rescue” excavation at Ita Yemoo, Ile-Ife (Nigeria), to investigate the fortuitous discovery of rare brass artifacts by laborers preparing the land for a construction project. Ita Yemoo soon emerged as a significant site, and Willett conducted subsequent archaeological campaigns between 1958 and 1963. The site became famous for its “bronzes” and several terracotta heads excavated in situ, which became icons of Ife’s “florescence” period during the 13th and 14th centuries CE. However, the fame of the site contrasts with the absence of detailed published material on its archaeology. In this paper, we use photographs, sketches, and field notebooks from the rich but little-known archival collection donated by Frank Willett to the University of Glasgow, to reconstruct the details of his first season at this site, interpret his findings and reflect on the necessity to rediscover and publish the lost archives of Africa’s archaeological heritage. Entre décembre 1957 et janvier 1958, Frank Willett dirigea une fouille de sauvetage à Ita Yemoo, Ile-Ife (Nigéria), afin d’apporter un éclairage scientifique sur la découverte fortuite par les ouvriers d’un chantier de construction d’un groupe de rares artefacts en laiton. Ita Yemoo allait se révéler être un site archéologique majeur, et F. Willett y poursuivit ses travaux de 1958 à 1963. Le site devint fameux pour ses « bronzes » et pour plusieurs têtes en terre cuite découvertes in situ, élevées au rang d’icônes de l’art d’Ife durant sa période de « florescence » entre les xiiie et xive siècles de notre ère. Son renom contraste cependant avec l’absence de publication détaillée de son archéologie. Dans cet article, nous faisons usage de photographies, croquis et notes de terrain extraits d’un fonds d’archives, riche mais encore peu connu, légué par Frank Willett à l’université de Glasgow ; notre objectif est de reconstituer les détails de sa première saison de fouilles sur ce site, interpréter ses observations et proposer une réflexion sur la nécessité de redécouvrir et de publier les archives oubliées du patrimoine archéologique de l’Afrique

Centre de recherche sur la pré- et protohistoire de la Méditerranée – CRPPM

Marie Laroche, doctorante Apparition et développement des premières métallurgies en Europe occidentale (IVe-IIIe millénaires avant J.-C.) Le séminaire a permis de dresser un état des connaissances sur les modalités et les impacts du développement de la première métallurgie du cuivre. Il ciblait en particulier les techniques d’extraction minière connues et les procédés de transformation des minerais de cuivre. Pour bien comprendre le schéma de diffusion, notre développement a pour point de dép..

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

Loss of secreted phospholipase A2 receptor (PLA2R1) has recently been found to render human primary cells more resistant to senescence whereas increased PLA2R1 expression is able to induce cell cycle arrest, cancer cell death or blockage of cancer cell transformation in vitro, suggesting that PLA2R1 displays tumor suppressive activities. Here we report that PLA2R1 expression strongly decreases in samples of human renal cell carcinoma (RCC). Knockdown of PLA2R1 increases renal cancer cell tumorigenicity supporting a role of PLA2R1 loss to promote in vivo RCC growth. Most RCC result from Von Hippel-Lindau (VHL) tumor suppressor loss-of-function and subsequent gain-of-function of the oncogenic HIF-2alpha/c-MYC pathway. Here, by genetically manipulating VHL, HIF-2alpha and c-MYC, we demonstrate that loss of VHL, stabilization of HIF-2alpha and subsequent increased c-MYC activity, binding and transcriptional repression, through induction of PLA2R1 DNA methylation closed to PLA2R1 transcriptional start site, results in decreased PLA2R1 transcription. Our results describe for the first time an oncogenic pathway leading to PLA2R1 transcriptional repression and the importance of this repression for tumor growth

Toll-like receptor 4 selective inhibition in medullar microenvironment alters multiple myeloma cell growth.

peer reviewedBone marrow (BM) mesenchymal stromal cells (MSCs) are abnormal in multiple myeloma (MM) and play a critical role by promoting growth, survival, and drug resistance of MM cells. We observed higher Toll-like receptor 4 (TLR4) gene expression in MM MSCs than in MSCs from healthy donors. At the clinical level, we highlighted that TLR4 expression in MM MSCs evolves in parallel with the disease stage. Thus, we reasoned that the TLR4 axis is pivotal in MM by increasing the protumor activity of MSCs. Challenging primary MSCs with TLR4 agonists increased the expression of CD54 and interleukin-6 (IL-6), 2 factors directly implicated in MM MSC-MM cell crosstalk. Then, we evaluated the therapeutic efficacy of a TLR4 antagonist combined or not with conventional treatment in vitro with MSC-MM cell coculture and in vivo with the Vk*MYC mouse model. Selective inhibition of TLR4 specifically reduced the MM MSC ability to support the growth of MM cells in an IL-6-dependent manner and delayed the development of MM in the Vk*MYC mouse model by altering the early disease phase in vivo. For the first time, we demonstrate that specific targeting of the pathological BM microenvironment via TLR4 signaling could be an innovative approach to alter MM pathology development

Refouiller le site urbain d’Ile-Ife. Vers une chronologie de l’ancienne ville yoruba et une réévaluation de son système d’enceintes

Carnet d'Afriques. Actualité de la recherche en histoire de l'Afrique avant le XXe siècl

Perdus dans l’espace ? Reconstituer les chantiers archéologiques de Frank Willett à Ita Yemoo, Ile-Ife, Nigéria : fouilles de sauvetage (1957-1958) et tranchée XIV (1962-1963)

International audienceFrom December 1957 to January 1958, Frank Willett conducted a “rescue” excavation at Ita Yemoo, Ile-Ife (Nigeria), to investigate the fortuitous discovery of rare brass artifacts by laborers preparing the land for a construction project. Ita Yemoo soon emerged as a significant site, and Willett conducted subsequent archaeological campaigns between 1958 and 1963. The site became famous for its “bronzes” and several terracotta heads excavated in situ, which became icons of Ife’s “florescence” period during the 13th and 14th centuries CE. However, the fame of the site contrasts with the absence of detailed published material on its archaeology. In this paper, we use photographs, sketches, and field notebooks from the rich but little-known archival collection donated by Frank Willett to the University of Glasgow, to reconstruct the details of his first season at this site, interpret his findings and reflect on the necessity to rediscover and publish the lost archives of Africa’s archaeological heritage.Entre décembre 1957 et janvier 1958, Frank Willett dirigea une fouille de sauvetage à Ita Yemoo, Ile-Ife (Nigéria), afin d’apporter un éclairage scientifique sur la découverte fortuite par les ouvriers d’un chantier de construction d’un groupe de rares artefacts en laiton. Ita Yemoo allait se révéler être un site archéologique majeur, et F. Willett y poursuivit ses travaux de 1958 à 1963. Le site devint fameux pour ses « bronzes » et pour plusieurs têtes en terre cuite découvertes in situ, élevées au rang d’icônes de l’art d’Ife durant sa période de « florescence » entre les xiiie et xive siècles de notre ère. Son renom contraste cependant avec l’absence de publication détaillée de son archéologie. Dans cet article, nous faisons usage de photographies, croquis et notes de terrain extraits d’un fonds d’archives, riche mais encore peu connu, légué par Frank Willett à l’université de Glasgow ; notre objectif est de reconstituer les détails de sa première saison de fouilles sur ce site, interpréter ses observations et proposer une réflexion sur la nécessité de redécouvrir et de publier les archives oubliées du patrimoine archéologique de l’Afrique

Multiparty attention management for an embodied conversational agent

International audienc

Data-Driven Generation of Eyes and Head Movements of a Social Robot in Multiparty Conversation

International audienceGiven the importance of gaze in Human-Robot Interactions (HRI), many gaze control models have been developed. However, these models are mostly built for dyadic face-to-face interaction. Gaze control models for multiparty interaction are more scarce. We here propose and evaluate data-driven gaze control models for a robot game animator in a three-party interaction. More precisely, we used Long Short-Term Memory networks to predict gaze target and context-aware head movements given robot’s communication intents and observed activities of its human partners. After comparing objective performance of our data-driven model with a baseline and ground truth data, an online audiovisual perception study was conducted to compare the acceptability of these control models in comparison with low-anchor incongruent speech and gaze sequences driving the Furhat robot. The results show that our data-driven prediction of gaze targets is viable, but that third-party raters are not so sensitive to controls with congruent head movements

Highlighting a Solid-Like Behavior in RTILs: Tri-octylmethylammonium Bis(trifluoromethanesulfonyl)imide TOMA-TFSI

International audienceCareful measurements of the dynamic response of the room -temperature ionic liquid (RTIL) trioctylmethylammonium bis(trifluoromethanesulfonyl)imide reveal that it exhibits actually a (low-frequency) solid-like response when solicited at the submillimeter scale with a low shear strain. The solid-like response is measured away from the glass transition (at around 100 °C above Tg), ruling out reminiscent transitional effects but suggesting that the dynamic properties of the RTIL are governed by long-range elastic intermolecular interactions