Brain Amino Acids and Biogenic Amines Under Various Atmospheric Mixtures Semiannual Report, May - 31 Oct. 1966

Brain biochemistry of rats exposed to pure oxyge

Classification of Generalized Multiresolution Analyses

We discuss how generalized multiresolution analyses (GMRAs), both classical and those defined on abstract Hilbert spaces, can be classified by their multiplicity functions $m$ and matrix-valued filter functions $H$. Given a natural number valued function $m$ and a system of functions encoded in a matrix $H$ satisfying certain conditions, a construction procedure is described that produces an abstract GMRA with multiplicity function $m$ and filter system $H$. An equivalence relation on GMRAs is defined and described in terms of their associated pairs $(m,H)$. This classification system is applied to classical examples in $L^2 (\mathbb R^d)$ as well as to previously studied abstract examples.Comment: 18 pages including bibliograp

Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.

Mammalian voltage-gated K+ channels are assemblies of pore-forming alpha-subunits and modulating beta-subunits. To operate correctly, Kv4 alpha-subunits in the heart and central nervous system require recently identified beta-subunits of the neuronal calcium sensing protein family called K+ channel-interacting proteins (KChIPs). Here, Kv4.2.KChIP2 channels are purified, integrity of isolated complexes confirmed, molar ratio of the subunits determined, and subunit valence established. A complex has 4 subunits of each type, a stoichiometry expected for other channels employing neuronal calcium sensing beta-subunits

Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.

Regulatory KChIP2 subunits assemble with pore-forming Kv4.2 subunits in 4:4 complexes to produce native voltage-gated potassium (Kv) channels like cardiac I(to) and neuronal I(A) subtypes. Here, negative stain electron microscopy (EM) and single particle averaging reveal KChIP2 to create a novel approximately 35 x 115 x 115 Angstrom, intracellular fenestrated rotunda: four peripheral columns that extend down from the membrane-embedded portion of the channel to enclose the Kv4.2 "hanging gondola" (a platform held beneath the transmembrane conduction pore by four internal columns). To reach the pore from the cytosol, ions traverse one of four external fenestrae to enter the rotundal vestibule and then cross one of four internal windows in the gondola

Trial design: how must we move ahead?

Scleroderma is clinically heterogeneous and a variety of plausible mechanisms of disease have been hypothesized. Recent years have witnessed a significant improvement in overall survival although all of the gains in management have been therapies for specific organ involvement, e.g. renal crisis and pulmonary arterial hypertension. Future studies will rely on improved clinical science, which involves structured validation of proposed measures of outcome; development of a combined response index; and further refinement of specific subsets of disease expression. Immunoablation with stem cell reconstitution is an example of aggressive therapy chosen as appropriate for a particularly severe disease subset and in whom the pilot data are encouraging. Good science and clinical ethics force continued consideration of equipoise between risk and benefi

On Algorithmic Statistics for space-bounded algorithms

Algorithmic statistics studies explanations of observed data that are good in the algorithmic sense: an explanation should be simple i.e. should have small Kolmogorov complexity and capture all the algorithmically discoverable regularities in the data. However this idea can not be used in practice because Kolmogorov complexity is not computable. In this paper we develop algorithmic statistics using space-bounded Kolmogorov complexity. We prove an analogue of one of the main result of `classic' algorithmic statistics (about the connection between optimality and randomness deficiences). The main tool of our proof is the Nisan-Wigderson generator.Comment: accepted to CSR 2017 conferenc