Response of pulmonary artery intimal sarcoma to surgery, radiotherapy and chemotherapy: a case report

<p>Abstract</p> <p>Introduction</p> <p>Pulmonary artery intimal sarcoma is a rare disease with no characteristic symptoms. It is difficult to diagnose early and is frequently misdiagnosed as a pulmonary embolism.</p> <p>Case presentation</p> <p>Here we report a case of pulmonary artery intimal sarcoma in a 54-year-old woman presenting with complaints of shortness of breath on exertion. Echocardiography and a computed tomography scan showed that the right pulmonary artery trunk was blocked by a low-density mass. The patient was diagnosed with pulmonary artery intimal sarcoma by pathology and a complete mass resection was performed. After experiencing 10 months of disease-free survival, she was re-admitted because of the recurrence and metastasis of the tumor. Radiotherapy and chemotherapy were performed; however, only limited success was achieved. The patient died 15 months after the initial onset of symptoms.</p> <p>Conclusion</p> <p>Some patients with intimal sarcoma of the pulmonary artery can benefit from radiotherapy and chemotherapy as well as surgery.</p

Sarcoma intimal de arteria pulmonar: una causa infrequente de hipertensión pulmonar

El sarcoma intimal de la arteria pulmonar es un tumor infrecuente que habitualmente se diagnostica en el acto quirúrgico o la autopsia. Por lo general crece regionalmente, con poca capacidad de metastatizar. El diagnóstico es difícil y con frecuencia se retrasa debido a la naturaleza inespecífica de los síntomas. Su baja frecuencia y el crecimiento insidioso hacen que a menudo se confunda con una tromboembolia pulmonar, y por ello se trata inadecuadamente con anticoagulación prolongada o trombólisis. El pronóstico es malo, con una media de supervivencia de 12 meses desde el inicio de los síntomas. Presentamos el caso de una paciente a quien se diagnosticó preoperatoriamente un sarcoma intimal de la arteria pulmonar que se sometió a resección quirúgica, sin que se evidenciase recurrencia en el seguimiento a largo plazo. También se realiza una revisión de la bibliografía

Plano general de Barcelona: la febre tifoide a Barcelona: gràfic de l'epidèmia de l'any 1914

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A Single Amino Acid Change within Antigenic Domain II of the Spike Protein of Bovine Coronavirus Confers Resistance to Virus Neutralization

The spike glycoprotein is a major neutralizing antigen of bovine coronavirus (BCV). Conformational neutralizing epitopes of group A and group B monoclonal antibodies (MAbs) have previously been mapped to two domains at amino acids 351 to 403 (domain I) and amino acids 517 to 621 (domain II). To further map antigenic sites, neutralization escape mutants of BCV were selected with a group A MAb which has both in vitro and in vivo virus-neutralizing ability. The escape mutants were demonstrated to be neutralization resistant to the selecting group A MAb and remained sensitive to neutralization by a group B MAb. In radioimmunoprecipitation assays, the spike proteins of neutralization escape mutants were shown to have lost their reactivities with the selecting group A MAb. Sequence analysis of the spike protein genes of the escape mutants identified a single nucleotide substitution of C to T at position 1583, resulting in the change of alanine to valine at amino acid position 528 (A528V). The mutation occurs in domain II and in a location which corresponds to the hypervariable region of the spike protein of the coronavirus mouse hepatitis virus. Experimental introduction of the A528V mutation into the wild-type spike protein resulted in the loss of MAb binding of the mutant protein, confirming that the single point mutation was responsible for the escape of BCV from immunological selective pressure