The relative fitness of drug-resistant Mycobacterium tuberculosis: a modelling study of household transmission in Peru.

The relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly derived from in vitro experiments. Measuring fitness in the field allows us to determine how the environment influences the spread of resistance. We designed a household structured, stochastic mathematical model to estimate the fitness costs associated with multidrug resistance (MDR) carriage in Mtb in Lima, Peru during 2010-2013. By fitting the model to data from a large prospective cohort study of TB disease in household contacts, we estimated the fitness, relative to susceptible strains with a fitness of 1, of MDR-Mtb to be 0.32 (95% credible interval: 0.15-0.62) or 0.38 (0.24-0.61), if only transmission or progression to disease, respectively, was affected. The relative fitness of MDR-Mtb increased to 0.56 (0.42-0.72) when the fitness cost influenced both transmission and progression to disease equally. We found the average relative fitness of MDR-Mtb circulating within households in Lima, Peru during 2010-2013 to be significantly lower than concurrent susceptible Mtb If these fitness levels do not change, then existing TB control programmes are likely to keep MDR-TB prevalence at current levels in Lima, Peru

World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72281/1/j.1365-2893.2002.00304.x.pd

Factors affecting temperature changes in dressed poultry during refrigeration

Publication authorized October 27, 1941.Includes bibliographical references (pages 37-39)

New constraints for heavy axion-like particles from supernovae

We derive new constraints on the coupling of heavy pseudoscalar (axion-like) particles to photons, based on the gamma ray flux expected from the decay of these particles into photons. After being produced in the supernova core, these heavy axion-like particles would escape and a fraction of them would decay into photons before reaching the Earth. We have calculated the expected flux on Earth of these photons from the supernovae SN 1987A and Cassiopeia A and compared our results to data from the Fermi Large Area Telescope. This analysis provides strong constraints on the parameter space for axion-like particles. For a particle mass of 100 MeV, we find that the Peccei-Quinn constant, f_a, must be greater than about 10^{15} GeV. Alternatively, for fa=10^{12} GeV, we exclude the mass region between approximately 100 eV and 1 GeV.Comment: 14 pages, 4 figures. Version published in JCAP. Major changes in the exposition. Added a figure. Added appendix. Minor changes in the results. Some changes in the bibliograph

TARGET: toward a solution for the readout electronics of the Cherenkov Telescope Array

TARGET is an application specific integrated circuit (ASIC) designed to read out signals recorded by the photosensors in cameras of very-high-energy gamma-ray telescopes exploiting the imaging of Cherenkov radiation from atmospheric showers. TARGET capabilities include sampling at a high rate (typically 1 GSample/s), digitization, and triggering on the sum of four adjacent pixels. The small size, large number of channels read out per ASIC (16), low cost per channel, and deep buffer for trigger latency (~16 $\mu$s at 1 GSample/s) make TARGET ideally suited for the readout in systems with a large number of telescopes instrumented with compact photosensors like multi-anode or silicon photomultipliers combined with dual-mirror optics. The possible advantages of such systems are better sensitivity, a larger field of view, and improved angular resolution. The two latest generations of TARGET ASICs, TARGET 5 and TARGET 7, are soon to be used for the first time in two prototypes of small-sized and medium-sized dual-mirror telescopes proposed in the framework of the Cherenkov Telescope Array (CTA) project. In this contribution we report on the performance of the TARGET ASICs and discuss future developments.Comment: 8 pages, 3 figures. In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

The use of vegetable protein concentrates for raising turkeys

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Egg weight in the domestic fowl

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Some production costs with growing chicks

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TARGET: A Digitizing And Trigger ASIC For The Cherenkov Telescope Array

The future ground-based gamma-ray observatory Cherenkov Telescope Array (CTA) will feature multiple types of imaging atmospheric Cherenkov telescopes, each with thousands of pixels. To be affordable, camera concepts for these telescopes have to feature low cost per channel and at the same time meet the requirements for CTA in order to achieve the desired scientific goals. We present the concept of the TeV Array Readout Electronics with GSa/s sampling and Event Trigger (TARGET) Application Specific Circuit (ASIC), envisaged to be used in the cameras of various CTA telescopes, e.g. the Gamma-ray Cherenkov Telescope (GCT), a proposed 2-Mirror Small-Sized Telescope, and the Schwarzschild-Couder Telescope (SCT), a proposed Medium-Sized Telescope. In the latest version of this readout concept the sampling and trigger parts are split into dedicated ASICs, TARGET C and T5TEA, both providing 16 parallel input channels. TARGET C features a tunable sampling rate (usually 1 GSa/s), a 16k sample deep buffer for each channel and on-demand digitization and transmission of waveforms with typical spans of ~100 ns. The trigger ASIC, T5TEA, provides 4 low voltage differential signal (LVDS) trigger outputs and can generate a pedestal voltage independently for each channel. Trigger signals are generated by T5TEA based on the analog sum of the input in four independent groups of four adjacent channels and compared to a threshold set by the user. Thus, T5TEA generates four LVDS trigger outputs, as well as 16 pedestal voltages fed to TARGET C independently for each channel. We show preliminary results of the characterization and testing of TARGET C and T5TEA.Comment: 6 pages, 8 figures, Proceedings of the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2016