Non-Rectangular Convolutions and (Sub-)Cadences with Three Elements

The discrete acyclic convolution computes the 2n-1 sums sum_{i+j=k; (i,j) in [0,1,2,...,n-1]^2} (a_i b_j) in O(n log n) time. By using suitable offsets and setting some of the variables to zero, this method provides a tool to calculate all non-zero sums sum_{i+j=k; (i,j) in (P cap Z^2)} (a_i b_j) in a rectangle P with perimeter p in O(p log p) time. This paper extends this geometric interpretation in order to allow arbitrary convex polygons P with k vertices and perimeter p. Also, this extended algorithm only needs O(k + p(log p)^2 log k) time. Additionally, this paper presents fast algorithms for counting sub-cadences and cadences with 3 elements using this extended method

Faster Queries for Longest Substring Palindrome After Block Edit

Palindromes are important objects in strings which have been extensively studied from combinatorial, algorithmic, and bioinformatics points of views. Manacher [J. ACM 1975] proposed a seminal algorithm that computes the longest substring palindromes (LSPals) of a given string in O(n) time, where n is the length of the string. In this paper, we consider the problem of finding the LSPal after the string is edited. We present an algorithm that uses O(n) time and space for preprocessing, and answers the length of the LSPals in O(l + log log n) time, after a substring in T is replaced by a string of arbitrary length l. This outperforms the query algorithm proposed in our previous work [CPM 2018] that uses O(l + log n) time for each query

Longest substring palindrome after edit

It is known that the length of the longest substring palindromes (LSPals) of a given string T of length n can be computed in O(n) time by Manacher\u27s algorithm [J. ACM \u2775]. In this paper, we consider the problem of finding the LSPal after the string is edited. We present an algorithm that uses O(n) time and space for preprocessing, and answers the length of the LSPals in O(log (min {sigma, log n })) time after single character substitution, insertion, or deletion, where sigma denotes the number of distinct characters appearing in T. We also propose an algorithm that uses O(n) time and space for preprocessing, and answers the length of the LSPals in O(l + log n) time, after an existing substring in T is replaced by a string of arbitrary length l

Optimal LZ-End Parsing Is Hard

LZ-End is a variant of the well-known Lempel-Ziv parsing family such that each phrase of the parsing has a previous occurrence, with the additional constraint that the previous occurrence must end at the end of a previous phrase. LZ-End was initially proposed as a greedy parsing, where each phrase is determined greedily from left to right, as the longest factor that satisfies the above constraint [Kreft & Navarro, 2010]. In this work, we consider an optimal LZ-End parsing that has the minimum number of phrases in such parsings. We show that a decision version of computing the optimal LZ-End parsing is NP-complete by showing a reduction from the vertex cover problem. Moreover, we give a MAX-SAT formulation for the optimal LZ-End parsing adapting an approach for computing various NP-hard repetitiveness measures recently presented by [Bannai et al., 2022]. We also consider the approximation ratio of the size of greedy LZ-End parsing to the size of the optimal LZ-End parsing, and give a lower bound of the ratio which asymptotically approaches 2

Detecting k-(Sub-)Cadences and Equidistant Subsequence Occurrences

The equidistant subsequence pattern matching problem is considered. Given a pattern string $P$ and a text string $T$, we say that $P$ is an \emph{equidistant subsequence} of $T$ if $P$ is a subsequence of the text such that consecutive symbols of $P$ in the occurrence are equally spaced. We can consider the problem of equidistant subsequences as generalizations of (sub-)cadences. We give bit-parallel algorithms that yield $o(n^2)$ time algorithms for finding $k$-(sub-)cadences and equidistant subsequences. Furthermore, $O(n\log^2 n)$ and $O(n\log n)$ time algorithms, respectively for equidistant and Abelian equidistant matching for the case $|P| = 3$, are shown. The algorithms make use of a technique that was recently introduced which can efficiently compute convolutions with linear constraints

Data structures for computing unique palindromes in static and non-static strings

A palindromic substring $T[i.. j]$ of a string $T$ is said to be a shortest unique palindromic substring (SUPS) in $T$ for an interval $[p, q]$ if $T[i.. j]$ is a shortest palindromic substring such that $T[i.. j]$ occurs only once in $T$, and $[i, j]$ contains $[p, q]$. The SUPS problem is, given a string $T$ of length $n$, to construct a data structure that can compute all the SUPSs for any given query interval. It is known that any SUPS query can be answered in $O(\alpha)$ time after $O(n)$-time preprocessing, where $\alpha$ is the number of SUPSs to output [Inoue et al., 2018]. In this paper, we first show that $\alpha$ is at most $4$, and the upper bound is tight. We also show that the total sum of lengths of minimal unique palindromic substrings of string $T$, which is strongly related to SUPSs, is $O(n)$. Then, we present the first $O(n)$-bits data structures that can answer any SUPS query in constant time. Also, we present an algorithm to solve the SUPS problem for a sliding window that can answer any query in $O(\log\log W)$ time and update data structures in amortized $O(\log\sigma + \log\log W)$ time, where $W$ is the size of the window, and $\sigma$ is the alphabet size. Furthermore, we consider the SUPS problem in the after-edit model and present an efficient algorithm. Namely, we present an algorithm that uses $O(n)$ time for preprocessing and answers any $k$ SUPS queries in $O(\log n\log\log n + k\log\log n)$ time after single character substitution. Finally, as a by-product, we propose a fully-dynamic data structure for range minimum queries (RmQs) with a constraint where the width of each query range is limited to poly-logarithmic. The constrained RmQ data structure can answer such a query in constant time and support a single-element edit operation in amortized constant time

Regulation of cell migration and cytokine production by HGF-like protein (HLP)/macrophage stimulating protein (MSP) in primary microglia

金沢大学がん研究所分子標的がん医療研究開発センターHGF-like protein (HLP)/macrophage stimulating protein (MSP) is the only structural relative of hepatocyte growth factor (HGF), and is involved in the regulation of peripheral macrophage activation. However the actions of HLP in microglia, a species of macrophage in the nervous system, which is closely involved in the neural degeneration and regeneration, is not yet understood. This study found that Ron, the receptor for HLP, is expressed in primary microglia using RT-PCR, immunocytochemical staining and Western blotting, and, thus, sought to elucidate the function of HLP on the primary microglia. HLP promoted microglial migration without affecting cell survival and proliferation. Furthermore, real-time quantitative RT-PCR analysis revealed that HLP greatly increased the mRNA of inflammatory, cytokines, including IL-6 and GM-CSF, and iNOS. These findings provide the first evidence that HLP has the potential to modulate inflammatory actions of microglia, which proposes novel aspects for the process of degeneration and/or regeneration of the brain