Standard fractionation intensity modulated radiation therapy (IMRT) of primary and recurrent glioblastoma multiforme

<p>Abstract</p> <p>Background</p> <p>Intensity-modulated radiation therapy (IMRT) affords unparalleled capacity to deliver conformal radiation doses to tumors in the central nervous system. However, to date, there are few reported outcomes from using IMRT, either alone or as a boost technique, for standard fractionation radiotherapy for glioblastoma multiforme (GBM).</p> <p>Methods</p> <p>Forty-two patients were treated with IMRT alone (72%) or as a boost (28%) after 3-dimensional conformal radiation therapy (3D-CRT). Thirty-three patients with primary disease and 9 patients with recurrent tumors were included. Thirty-four patients (81%) had surgery, with gross tumor resection in 13 patients (36%); 22 patients (53%) received chemo-radiotherapy. The median total radiation dose for all patients was 60 Gy with a range from 30.6 to 74 Gy. Standard fractions of 1.8 Gy/day to 2.0 Gy/day were utilized.</p> <p>Results</p> <p>Median survival was 8.7 months, with 37 patients (88%) deceased at last contact. Nonparametric analysis showed no survival difference in IMRT-boost vs. IMRT-only groups.</p> <p>Conclusion</p> <p>While technically feasible, preliminary results suggest delivering standard radiation doses by IMRT did not improve survival outcomes in this series compared to historical controls. In light of this lack of a survival benefit and the costs associated with use of IMRT, future prospective trials are needed to evaluate non-survival endpoints such as quality of life and functional preservation. Short of such evidence, the use of IMRT for treatment of GBM needs to be carefully rationalized.</p

3C. 3-Ketosteroid receptors in GtoPdb v.2023.1

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17&#946;-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol

3C. 3-Ketosteroid receptors in GtoPdb v.2021.3

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [74, 215, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17&#946;-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol

The Emission and Distribution of Dust of the Torus of NGC 1068

We present observations of NGC 1068 covering the 19.7–53.0 μm wavelength range using FORCAST and HAWC+ on board SOFIA. Using these observations, high-angular-resolution infrared (IR) and submillimeter observations, we find an observational turnover of the torus emission in the 30–40 μm wavelength range with a characteristic temperature of 70–100 K. This component is clearly different from the diffuse extended emission in the narrow line and star formation regions at 10–100 μm within the central 700 pc. We compute 2.2–432 μm 2D images using the best inferred CLUMPY torus model based on several nuclear spectral energy distribution (SED) coverages. We find that when 1–20 μm SED is used, the inferred result gives a small torus size (<4 pc radius) and a steep radial dust distribution. The computed torus using the 1–432 μm SED provides comparable torus sizes, 5.1^(+0.4)_(-0.4) pc radius, and morphology to the recently resolved 432 μm Atacama Large Millimeter Array observations. This result indicates that the 1–20 μm wavelength range is not able to probe the full extent of the torus. The characterization of the turnover emission of the torus using the 30–60 μm wavelength range is sensitive to the detection of cold dust in the torus. The morphology of the dust emission in our 2D image at 432 μm is spatially coincident with the cloud distribution, while the morphology of the emission in the 1–20 μm wavelength range shows an elongated morphology perpendicular to the cloud distribution. We find that our 2D CLUMPY torus image at 12 μm can produce comparable results to those observed using IR interferometry

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries

Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of &lt; 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, the United Kingdom, and Croatia. Results Among 1,130 pediatric and young adults with radiographically confirmed DIPG, 122 (11%) were excluded. Of the 1,008 remaining patients, 101 (10%) were LTSs (survival ≥ 2 years). Median survival time was 11 months (interquartile range, 7.5 to 16 months), and 1-, 2-, 3-, 4-, and 5-year survival rates were 42.3% (95% CI, 38.1% to 44.1%), 9.6% (95% CI, 7.8% to 11.3%), 4.3% (95% CI, 3.2% to 5.8%), 3.2% (95% CI, 2.4% to 4.6%), and 2.2% (95% CI, 1.4% to 3.4%), respectively. LTSs, compared with STSs, more commonly presented at age &lt; 3 or &gt; 10 years (11% v 3% and 33% v 23%, respectively; P &lt; .001) and with longer symptom duration ( P &lt; .001). STSs, compared with LTSs, more commonly presented with cranial nerve palsy (83% v 73%, respectively; P = .008), ring enhancement (38% v 23%, respectively; P = .007), necrosis (42% v 26%, respectively; P = .009), and extrapontine extension (92% v 86%, respectively; P = .04). LTSs more commonly received systemic therapy at diagnosis (88% v 75% for STSs; P = .005). Biopsies and autopsies were performed in 299 patients (30%) and 77 patients (10%), respectively; 181 tumors (48%) were molecularly characterized. LTSs were more likely to harbor a HIST1H3B mutation (odds ratio, 1.28; 95% CI, 1.1 to 1.5; P = .002). Conclusion We report clinical, radiologic, and molecular factors that correlate with survival in children and young adults with DIPG, which are important for risk stratification in future clinical trials

The Emission and Distribution of Dust of the Torus of NGC 1068

We present observations of NGC 1068 covering the 19.7–53.0 μm wavelength range using FORCAST and HAWC+ on board SOFIA. Using these observations, high-angular-resolution infrared (IR) and submillimeter observations, we find an observational turnover of the torus emission in the 30–40 μm wavelength range with a characteristic temperature of 70–100 K. This component is clearly different from the diffuse extended emission in the narrow line and star formation regions at 10–100 μm within the central 700 pc. We compute 2.2–432 μm 2D images using the best inferred CLUMPY torus model based on several nuclear spectral energy distribution (SED) coverages. We find that when 1–20 μm SED is used, the inferred result gives a small torus size (<4 pc radius) and a steep radial dust distribution. The computed torus using the 1–432 μm SED provides comparable torus sizes, 5.1^(+0.4)_(-0.4) pc radius, and morphology to the recently resolved 432 μm Atacama Large Millimeter Array observations. This result indicates that the 1–20 μm wavelength range is not able to probe the full extent of the torus. The characterization of the turnover emission of the torus using the 30–60 μm wavelength range is sensitive to the detection of cold dust in the torus. The morphology of the dust emission in our 2D image at 432 μm is spatially coincident with the cloud distribution, while the morphology of the emission in the 1–20 μm wavelength range shows an elongated morphology perpendicular to the cloud distribution. We find that our 2D CLUMPY torus image at 12 μm can produce comparable results to those observed using IR interferometry

The places parents go: understanding the breadth, scope, and experiences of activity spaces for parents

The final publication is available at Springer via https://doi.org/10.1007/s10708-015-9690-yNeighborhood environments are related to parenting behaviors, which in turn have a life-long effect on children’s health and well-being. Activity spaces, which measure individual routine patterns of movement, may be helpful in assessing how physical and social environments shape parenting. In this study we use qualitative data and GIS mapping from four California cities to examine parental activity spaces. Parents described a number of factors that shape their activity spaces including caregiving status, the age of their children, and income. Parental activity spaces also varied between times (weekends vs. weekdays) and places (adult-only vs. child-specific places). Knowing how to best capture and study parental activity spaces could identify mechanisms by which environmental factors influence parenting behaviors and child health

The Cultural Project : Formal Chronological Modelling of the Early and Middle Neolithic Sequence in Lower Alsace

Starting from questions about the nature of cultural diversity, this paper examines the pace and tempo of change and the relative importance of continuity and discontinuity. To unravel the cultural project of the past, we apply chronological modelling of radiocarbon dates within a Bayesian statistical framework, to interrogate the Neolithic cultural sequence in Lower Alsace, in the upper Rhine valley, in broad terms from the later sixth to the end of the fifth millennium cal BC. Detailed formal estimates are provided for the long succession of cultural groups, from the early Neolithic Linear Pottery culture (LBK) to the Bischheim Occidental du Rhin Supérieur (BORS) groups at the end of the Middle Neolithic, using seriation and typology of pottery as the starting point in modelling. The rate of ceramic change, as well as frequent shifts in the nature, location and density of settlements, are documented in detail, down to lifetime and generational timescales. This reveals a Neolithic world in Lower Alsace busy with comings and goings, tinkerings and adjustments, and relocations and realignments. A significant hiatus is identified between the end of the LBK and the start of the Hinkelstein group, in the early part of the fifth millennium cal BC. On the basis of modelling of existing dates for other parts of the Rhineland, this appears to be a wider phenomenon, and possible explanations are discussed; full reoccupation of the landscape is only seen in the Grossgartach phase. Radical shifts are also proposed at the end of the Middle Neolithic