Star Formation and Chemical Enrichment in Protoclusters

We examine star formation and chemical enrichment in protoclusters (PCs) using cosmological zoom-in hydrodynamic simulations. We find that the total star formation rate (SFR) in all PC ($>10^{14.4}\,h^{-1}$M$_\odot$) reaches $>10^4\,\mathrm{M}_\odot \mathrm{yr}^{-1}$ at $z=3$, equivalent to the observed PCs. The SFR in the Core region accounts for about $30\%$ of the total star formation in the PC at $z\gtrsim1$, suggesting the importance of the outer regions to reveal the evolution of galaxy clusters. We find that the total SFR of PC is dominated by galaxies with $10^{10}\,\le\,(\mathrm{M}_\star/M_\odot)\,\le\,10^{11}$, while more massive galaxies dominate the SFR in the Core. For the chemical abundance evolution, we find that the higher-density region has a higher metallicity and faster evolution. We show that the [O/Fe] vs. [Fe/H] relation turns down in the Core at $z=3.4$ due to the enrichment of Fe by Type Ia supernovae. We find no environmental effects for the mass--metallicity relations (MZR) or $\log$(N/O) vs. $12+\log$(O/H) for galaxies. We find that the chemical enrichment in galaxy clusters proceeds faster in the high redshift Universe ($z>1$). Our work will benefit future tomographic observations, particularly using PCs as unique probes of accelerated structure formation and evolution in high-density regions of the universe.Comment: 19 pages, 18 figures, 2 tables, 2 appendices, Accepted for publication in MNRA

1-[(2-Methyl-8-quinol­yl)amino­methyl­ene]naphthalen-2(1H)-one

The mol­ecule of the title compound, C21H16N2O, exists in the keto form and the C=O and N—H bonds are mutually cis in the crystal structure, although an enol form would be possible through tautomerism. The dihedral angle between the quinoline and the naphthalene systems is 22.04 (2)°. A bifurcated intramolecular N—H⋯(O,N) hydrogen bond is present

Probing Chemical Enrichment in Extremely Metal-Poor Galaxies and First Galaxies

The chemical composition of galaxies offers vital insights into their formation and evolution. A key aspect of this study is the correlation between helium abundance (He/H) and metallicity, which is instrumental in estimating the primordial helium generated by Big Bang nucleosynthesis. We study the chemical enrichment history of low-metallicity galaxies, specifically focusing on extremely metal-poor galaxies (EMPGs) and the first galaxies, using the one-zone model and cosmological hydrodynamic simulations. Our one-zone model, using the Limongi & Chieffi (2018) yield, aligns well with observed high He/H ratios at low metallicities and reproduces Fe/O ratios akin to EMPGs. Conversely, the Nomoto et al. (2013) yield does not fully match the high Fe/O ratios seen in EMPGs. Our cosmological hydrodynamic simulations of the first galaxy successfully replicate the stellar mass and star formation rate of galaxies like GN-z11 but fail to produce metallicity and high He/H at low O/H. This is consistent with the results of the one-zone model, which shows that the slope of the He/H-O/H relation is moderate in young, actively star-forming galaxies, suggesting the importance of using galaxies with similar star formation histories for the fit. These results highlight the need for high-resolution simulations and expanded observational datasets to refine our understanding of early galactic chemical evolution.Comment: 14 pages, 7 figures, 1 table, submitted to Ap

Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

Fukushima K., Kudo H., Oka K., et al. Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation. Bone Marrow Transplantation , (2024); https://doi.org/10.1038/s41409-024-02250-1.In patients undergoing haematopoietic stem-cell transplantation (HSCT), the intestinal microbiota plays an important role in prognosis, transplant outcome, and complications such as graft-versus-host disease (GVHD). Our prior research revealed that patients undergoing HSCT substantially differed from healthy controls. In this retrospective study, we showed that administering Clostridium butyricum MIYAIRI 588 (CBM588) as a live biotherapeutic agent is associated with maintaining intestinal microbiota in the early post-HSCT period. Alpha diversity, which reflects species richness, declined considerably in patients who did not receive CBM588, whereas it remained consistent in those who received CBM588. In addition, β-diversity analysis revealed that CBM588 did not alter the gut microbiota structure at 7–21 days post-HSCT. Patients who developed GVHD showed structural changes in their microbiota from the pre-transplant period, which was noticeable on day 14 before developing GVHD. Enterococcus was significantly prevalent in patients with GVHD after HSCT, and the population of Bacteroides was maintained from the pre-HSCT period through to the post-HSCT period. Patients who received CBM588 exhibited a contrasting trend, with lower relative abundances of both genera Enterococcus and Bacteroides. These results suggest that preoperative treatment with CBM588 could potentially be beneficial in maintaining intestinal microbiota balance

Input Current-Ripple Consideration for the Pulse-link DC-AC Converter for Fuel Cells by Small Series LC Circuit

This paper mentions the input current ripple reduction method of the Pulse-link DC-AC Converter for Fuel Cells. The conventional DC-AC converter for fuel cells is interpolated large capacitor between boost converter stage and PWM inverter stage. That capacitor disturbs the size reduction of this unit. To overcome this problem, authors have proposed a novel topology called as Pulse-link DC-AC converter. The proposed topology provides boosted-voltage pulse directly to PWM inverter. This topology does not require large capacitor between two stages. Instead, small values of inductor and capacitor are connected series and inserted between two stages in parallel. This paper examines the relationship between the inductor and capacitor values and input current-ripple. As the result, inductor value has the relationship with current-ripple.24th Annual IEEE Applied Power Electronics Conference and Exposition, APEC 2009; Washington, DC; 15 February 2009 through 19 February 200

Adjuvant Chemotherapy with Gemcitabine for Resected Biliary Tract Cancer: A Single-Arm Phase 2 Study

Article信州医学雑誌 65(2): 99-111(2017)journal articl

A Report on Hydrographic Activities Following the Great East Japan Earthquake

The Great East Japan Earthquake (Mw9.0) on 11 March 2011 accompanied with a huge tsunami of more than 10 meters in height devastated many cities and ports along the Pacific coast of northeastern Japan, and claimed nearly 20,000 lives with many of them still missing. This report reviews actions taken by the Japan Hydrographic and Oceanographic Department (JHOD) after this unprecedented disaster. Immediately after the earthquake, the JHOD carried out hydrographic surveys for the urgent need to help clear the passage in ports due to sunken debris swept away by the tsunami. These surveys have enabled the vessels with relief supplies on board for the affected areas to enter the ports. The JHOD revisited the affected ports for the next stage of hydrographic surveys. These surveys will contribute to revised nautical charts based on new data collected after the earthquake, and includes the ongoing restoration and reconstruction work of quays and port facilities. This stage includes the re-determination of the datum level of the affected ports, which is necessary because of large subsidence being reported in the areas. All of these efforts by the JHOD clearly demonstrate the significance of the hydrographic activities in case of the post-quake emergency situation, not only for the safety of navigation but also for economic recovery

トクシマ コウケツアツ トウニョウビョウ study 2011 : コウケツアツ トウニョウビョウ ガッペイ レイ ニ カンスル タシセツ ケンキュウ

Cardiologists and diabetologists in Tokushima Prefecture investigated patients with hypertension and diabetes mellitus on treatment in２０１１. The findings were compared with our year‐２００４ data. The study population comprised ２３６ patients with hypertension and diabetes mellitus being treated by cardiologists（C２０１１group）, and ３９５ patients with the same condition being treated by diabetologists（D２０１１group）. The mean number of antihypertensives used per patient was１．９for the C２０１１group and１．６for the D２０１１group. In these two groups, calcium antagonists were the most frequently used drugs. Renin-angiotensin system（RAS）inhibitors were used in７１．５％ of the patients in the C２０１１group and７０．０％ in the D２０１１group. The ratio of patients meeting the blood pressure criteria of the Japan Hypertension Society Guidelines was ２１．６％ for the C２００４group,２２．９％ for the D２００４group,２９．１％ for the C２０１１group, and１８．２％ for the D２０１１group. The mean number of antidiabetics used per patient was１．３for the two groups, glimepiride being most frequently used（３８．５％ for the C２０１１group,５８．１％ for the D２０１１group）, followed by α-glucosidase inhibitors and pioglitazone. Frequency of use of biguanide increased compared with２００４. The ratio of patients with HbA１c＜６．５％ was４０．７％ for the C２００４group, ２１．９％ for the D２００４ group, ４６．５％ for the C２０１１ group, and ４９．０％ for the D２０１１ group ; a significant improvement was observed in the D２０１１group compared with the D２００４group. The serum cholesterol control rate was４９．７％ for the C２００４group,４５．０％ for the D２００４group,６０．９％ for the C２０１１group, and５６．５％ for the D２０１１group. The ratio of patients achieving good control for all three parameters（blood pressure, blood glucose level, serum lipid level）was low at７．６％ for the C２００４group,６．７％ for the D２００４group,９．４％ for the C２０１１group, and９．０％ for the D２０１１ group. This managerial situation for the condition is unsatisfactory, necessitating efforts for even better control

Experimental investigation of a control scheme for a zero-detuning resonant sideband extraction interferometer for next-generation gravitational-wave detectors

Some next-generation gravitational-wave detectors, such as the American Advanced LIGO project and the Japanese LCGT project, plan to use power recycled resonant sideband extraction (RSE) interferometers for their interferometer's optical configuration. A power recycled zero-detuning (PRZD) RSE interferometer, which is the default design for LCGT, has five main length degrees of freedom that need to be controlled in order to operate a gravitational-wave detector. This task is expected to be very challenging because of the complexity of optical configuration. A new control scheme for a PRZD RSE interferometer has been developed and tested with a prototype interferometer. The PRZD RSE interferometer was successfully locked with the control scheme. It is the first experimental demonstration of a PRZD RSE interferometer with suspended test masses. The result serves as an important step for the operation of LCGT.Comment: 6 pages, 9 figrue