Flynn et al. Respond

Comment on Work as an Inclusive Part of Population Health Inequities Research and Prevention. [Am J Public Health. 2018] New Horizons for Occupational Health Surveillance. [Am J Public Health. 2018

Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Endoscopic submucosal dissection (ESD) permits removal of esophageal epithelial neoplasms <it>en bloc</it>, but is associated with esophageal stenosis, particularly when ESD involves the entire circumference of the esophageal lumen. We examined the effectiveness of systemic steroid administration for control of postprocedural esophageal stricture after complete circular ESD.</p> <p>Methods</p> <p>Seven patients who underwent wholly circumferential ESD for superficially extended esophageal squamous cell carcinoma were enrolled in this study. In 3 patients, prophylactic endoscopic balloon dilatation (EBD) was started on the third post-ESD day and was performed twice a week for 8 weeks. In 4 patients, oral prednisolone was started with 30 mg daily on the third post-ESD day, tapered gradually (daily 30, 30, 25, 25, 20, 15, 10, 5 mg for 7 days each), and then discontinued at 8 weeks. EBD was used as needed whenever patients complained of dysphagia.</p> <p>Results</p> <p><it>En bloc </it>ESD with tumor-free margins was safely achieved in all cases. Patients in the prophylactic EBD group required a mean of 32.7 EBD sessions; the postprocedural stricture was dilated up to 18 mm in diameter in these patients. On the other hand, systemic steroid administration substantially reduced or eliminated the need for EBD. Corticosteroid therapy was not associated with any adverse events. Post-ESD esophageal stricture after complete circular ESD was persistent, requiring multiple EBD sessions.</p> <p>Conclusions</p> <p>Use of oral prednisolone administration may be an effective treatment strategy for reducing post-ESD esophageal stricture after complete circular ESD.</p

Multi-wavelength analysis of 18um-selected galaxies in the AKARI/IRC monitor field towards the North Ecliptic Pole

We present an initial analysis of AKARI 18um-selected galaxies using all 9 photometric bands at 2-24um available in the InfraRed Camera (IRC), in order to demonstrate new capabilities of AKARI cosmological surveys. We detected 72 sources at 18um in an area of 50.2 arcmin^2 in the AKARI/IRC monitor field towards the North Ecliptic Pole (NEP). From this sample, 25 galaxies with probable redshifts z>~ 0.5 are selected with a single colour cut (N2-N3>0.1) for a detailed SED analysis with ground-based BVRi'z'JK data. Using an SED radiative transfer model of starbursts covering the wavelength range UV -- submm, we derive photometric redshifts from the optical-MIR SEDs of 18um-selected galaxies. From the best-fit SED models, we show that the IRC all-band photometry is capable of tracing the steep rise in flux at the blue side of the PAH 6.2um emission feature. This indicates that the IRC all-band photometry is useful to constrain the redshift of infrared galaxies, specifically for dusty galaxies with a less prominent 4000A break. Also, we find that the flux dip between the PAH 7.7 and 11.2um emission feature is recognizable in the observed SEDs of galaxies at z~1. By using such a colour anomaly due to the PAH and silicate absorption features, unique samples of ULIRGs at z~1, `silicate-break' galaxies, can be constructed from large cosmological surveys of AKARI towards the NEP, i.e. the NEP-Deep and NEP-Wide survey. This pilot study suggests the possibility of detecting many interesting galaxy properties in the NEP-Deep and Wide surveys, such as a systematic difference in SEDs between high- and low-z ULIRGs, and a large variation of the PAH inter-band strength ratio in galaxies at high redshifts. [abridged]Comment: Accepted for publication in PASJ, AKARI special issu

Polarization rotation via a monoclinic phase in the piezoelectric 92%PbZn1/3Nb2/3O3-8%PbTiO3

The origin of ultrahigh piezoelectricity in the relaxor ferroelectric PbZn1/3Nb2/3O3-PbTiO3 was studied with an electric field applied along the [001] direction. The zero-field rhombohedral R phase starts to follow the direct polarization path to tetragonal symmetry via an intermediate monoclinic M phase, but then jumps irreversibly to an alternate path involving a different type of monoclinic distortion. Details of the structure and domain configuration of this novel phase are described. This result suggests that there is a nearby R-M phase boundary as found in the Pb(Ti,Zr)O3 system.Comment: REVTeX file. 4 pages. New version after referees' comment

Theory of Thermal Conductivity in High-Tc Superconductors below Tc: Comparison between Hole-Doped and Electron-Doped Systems

In hole-doped high-Tc superconductors, thermal conductivity increases drastically just below Tc, which has been considered as a hallmark of a nodal gap. In contrast, such a coherence peak in thermal conductivity is not visible in electron-doped compounds, which may indicate a full-gap state such as a (d+is)-wave state. To settle this problem, we study the thermal conductivity in the Hubbard model using the fluctuation-exchange (FLEX) approximation, which predicts that the nodal d-wave state is realized in both hole-doped and electron-doped compounds. The contrasting behavior of thermal conductivity in both compounds originates from the differences in the hot/cold spot structure. In general, a prominent coherence peak in thermal conductivity appears in line-node superconductors only when the cold spot exists on the nodal line.Comment: 5 pages, to be published in J. Phys. Soc. Jpn. Vol.76 No.

Second harmonic generation and X-ray diffraction studies of pretransitional region in relaxor K(1-x) LixTaO3

Optical second-harmonic-generation(SHG) observations and precise X-ray diffraction experiments have been performed on quantum paraelectrics KTaO3 (KTO) and relaxor K(1-x)LixTaO3 with x=3% (KLT-3) and 7% (KLT-7). It is found in KLT-3 and KLT-7 that a pretransitional region exists between two characteristic temperatures Td and Tp (<Td). The average symmetry of the region is tetragonal with a weak lattice-deformation but non-polar in average. The temperature interval between Td and Tp is consistent with the interval on which neutron diffuse scatterings have been previously reported. These facts strongly suggest that polar micro-regions (PMRs) nucleate around Td and grow toward Tp. Below Tp, a larger deformation and a field-induced SH intensity start to develop, while no significant SHG appear in zero-field cooling process. The temperature dependence of the SH intensity below Tp coincides well with that of the tetragonality determined from the lattice deformation. The Landau-Devonshire phenomenological approach suggests that the ferroelectric phase transition at Tp is of first order and that it approaches the second order transition with the decrease of Li concentration. A marked increase of neutron diffraction intensities below Tp indicates that PMRs are transformed to ferroelectric micro-domains at Tp, and the micro-domains change to macroscopic ones under the electric field below Tp.Comment: 31 pages, 10 figure

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 as a Manganese Transporter

Manganese (Mn) homeostasis involves coordinated regulation of specific proteins involved in Mn influx and efflux. However, the proteins that are involved in detoxification/efflux have not been completely resolved, nor has the basis by which they select their metal substrate. Here, we compared six proteins, which were reported to be involved in Mn detoxification/efflux, by evaluating their ability to reduce Mn toxicity in chicken DT40 cells, finding that human ZnT10 (hZnT10) was the most significant contributor. A domain swapping and substitution analysis between hZnT10 and a zinc-specific transporter hZnT1 showed that residue N43, which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10's unique Mn mobilization activity; residues C52 and L242 in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10. Interestingly, the H->N reversion mutant in hZnT1 conferred Mn transport activity and loss of zinc transport activity. These results provide important information about Mn detoxification/efflux mechanisms in vertebrate cells as well as the molecular characterization of hZnT10 as a Mn transporter

Universal Static and Dynamic Properties of the Structural Transition in Pb(Zn1/3Nb2/3)O3

The relaxors Pb(Zn$_{1/3}$Nb$_{2/3}$)O$_{3}$ (PZN) and Pb(Mg$_{1/3}$Nb$_{2/3}$)O$_{3}$ (PMN) have very similar properties based on the dielectric response around the critical temperature $T_{c}$ (defined by the structural transition under the application of an electric field). It has been widely believed that these materials are quite different below $T_{c}$ with the unit cell of PMN remaining cubic while in PZN the low temperature unit cell is rhombohedral in shape. However, this has been clarified by recent high-energy x-ray studies which have shown that PZN is rhombohedral only in the skin while the shape of the unit cell in the bulk is nearly cubic. In this study we have performed both neutron elastic and inelastic scattering to show that the temperature dependence of both the diffuse and phonon scattering in PZN and PMN is very similar. Both compounds show a nearly identical recovery of the soft optic mode and a broadening of the acoustic mode below $T_{c}$. The diffuse scattering in PZN is suggestive of an onset at the high temperature Burns temperature similar to that in PMN. In contrast to PMN, we observe a broadening of the Bragg peaks in both the longitudinal and transverse directions below $T_{c}$. We reconcile this additional broadening, not observed in PMN, in terms of structural inhomogeneity in PZN. Based on the strong similarities between PMN and PZN, we suggest that both materials belong to the same universality class and discuss the relaxor transition in terms of the three-dimensional Heisenberg model with cubic anisotropy in a random field.Comment: 11 pages, 10 figures. Updated version after helpful referee comment

Structural, magnetic and electrical properties of single crystalline La_(1-x)Sr_xMnO_3 for 0.4 < x < 0.85

We report on structural, magnetic and electrical properties of Sr-doped LaMnO_3 single crystals for doping levels 0.4 < x < 0.85. The complex structural and magnetic phase diagram can only be explained assuming significant contributions from the orbital degrees of freedom. Close to x = 0.6 a ferromagnetic metal is followed by an antiferromagnetic metallic phase below 200 K. This antiferromagnetic metallic phase exists in a monoclinic crystallographic structure. Following theoretical predictions this metallic antiferromagnet is expected to reveal an (x^2-y^2)-type orbital order. For higher Sr concentrations an antiferromagnetic insulator is established below room temperature.Comment: 8 pages, 7 figure