Order and the Virtual: Toward a Deleuzian Cosmology

None provided, have taken the following from the "Introduction" Order is a more or less explicit topic for any thinker who undertakes to write about nature. Even those who assert that randomness or chaos is the most fundamental trait of nature are obliged to account for the apparent permanence, organisation and structure we observe around us. No less is true for Gilles Deleuze, who champions the power of chaos through his work. On one reading, Deleuze’s chief impulse is to wrench loose the lynchpins of order; to ‘affirm chaos’ and disarticulate the law of excluded middle; to refuse jurisdiction to laws of nature and render provisional its every constant; to banish identity and negation alike. If we are to be left with no fixed point, we might ask, what remains of order? This study is nevertheless an examination of that notion in Deleuze’s natural philosophy. For me the counter-reading is much more productive and insightful. Deleuze is rather a firm believer in order, even there where he affirms chaos. If we could furnish a ‘Deleuzian Question’ par excellence, it would be; ‘Given that there are no fixed points, how is order expressed in the world?’ This question is implicitly reprised across the entirety of his work and inflected at each stage by fresh vocabulary coined to treat it anew, as though for each new Deleuzian territory a new phrasebook is required

Wi-Fi based people tracking in challenging environments

People tracking is a key building block in many applications such as abnormal activity detection, gesture recognition, and elderly persons monitoring. Video-based systems have many limitations making them ineffective in many situations. Wi-Fi provides an easily accessible source of opportunity for people tracking that does not have the limitations of video-based systems. The system will detect, localise, and track people, based on the available Wi-Fi signals that are reflected from their bodies. Wi-Fi based systems still need to address some challenges in order to be able to operate in challenging environments. Some of these challenges include the detection of the weak signal, the detection of abrupt people motion, and the presence of multipath propagation. In this thesis, these three main challenges will be addressed. Firstly, a weak signal detection method that uses the changes in the signals that are reflected from static objects, to improve the detection probability of weak signals that are reflected from the person’s body. Then, a deep learning based Wi-Fi localisation technique is proposed that significantly improves the runtime and the accuracy in comparison with existing techniques. After that, a quantum mechanics inspired tracking method is proposed to address the abrupt motion problem. The proposed method uses some interesting phenomena in the quantum world, where the person is allowed to exist at multiple positions simultaneously. The results show a significant improvement in reducing the tracking error and in reducing the tracking delay

Rigorous dimension estimates for Cantor sets arising in Zaremba theory

We address the question of the accuracy of bounds used in the study of Zaremba’s conjecture. Specifically, we establish rigorous estimates on the Hausdorff dimension of certain Cantor sets which arise in the analysis of Zaremba’s conjecture in [5, 18, 19, 23]

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

The stochastic nature of errors in next-generation sequencing of circulating cell-free DNA.

Challenges with distinguishing circulating tumor DNA (ctDNA) from next-generation sequencing (NGS) artifacts limits variant searches to established solid tumor mutations. Here we show early and random PCR errors are a principal source of NGS noise that persist despite duplex molecular barcoding, removal of artifacts due to clonal hematopoiesis of indeterminate potential, and suppression of patterned errors. We also demonstrate sample duplicates are necessary to eliminate the stochastic noise associated with NGS. Integration of sample duplicates into NGS analytics may broaden ctDNA applications by removing NGS-related errors that confound identification of true very low frequency variants during searches for ctDNA without a priori knowledge of specific mutations to target