Impact of metabolism on immune responses

Producción CientíficaMetabolic processes have been long seen as means to generate energy in a live organism. However, recent discoveries on the field of immunology and metabolism have shown an increasing interrelation between these processes. The field of immunometabolism is gaining momentum and presents a huge impact for the clinical practice. Of particular attention is the chronic inflammation state in obesity, as well as asthma to mention a few. This special issue offers a selected and articulated overview of the examined topic. For this issue, we have included an interesting mix of reviews and original research articles, which underscore the relevance of metabolism in immune responses

Composición para suplemento alimenticio

Composición para suplemento alimenticio. Composición que comprende una combinación extrusionada de semilla de lino, salvado de trigo y harina de girasol. Además, la presente invención se refiere al uso de dicha composición como suplemento alimenticio para animales, y la obtención, mediante el uso de dicho suplemento, de leche enriquecida en ácidos -linolénico y ruménico.Peer reviewedConsejo Superior de Investigaciones Científicas (España), LODYN SL, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Institució Catalana de Recerca i Estudis Avançats (ICREA)B1 Patente con informe sobre el estado de la ténic

Ejecución de materiales docentes en las asignaturas de la materia Computadores en el Grado en Ingeniería Informática en Sistemas de Información

Memoria ID12-0198. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

CD148, a membrane protein tyrosine phosphatase, is able to induce tyrosine phosphorylation on human lymphocytes

Producción CientíficaCD148 is a new cluster of differentiation defined in the VI International Workshop on Leucocyte Differentiation Antigens. It has been identified as the hematopoietic form of a formerly described membrane protein tyrosine phosphatase called HPTP eta/ DEP-1. Previous data have demonstrated that this molecule is able to give rise to [Ca2+]i increase. In the present work we show its capability to induce protein tyrosine phosphorylation in human lymphocytes in spite of its intrinsic protein tyrosine phosphatase activity. The induction of kinase activity suggests the involvement of some protein tyrosine kinase based signaling pathway. The activation of this postulated kinase could be carried out through a direct association or via an adapter molecule

Composición para suplemento alimenticio

Composición para suplemento alimenticio. Composición que comprende una combinación extrusionada de semilla de lino, salvado de trigo y harina de girasol. Además, la presente invención se refiere al uso de dicha composición como suplemento alimenticio para animales, y la obtención, mediante el uso de dicho suplemento, de leche enriquecida en ácidos -linolénico y ruménico.Peer reviewedConsejo Superior de Investigaciones Científicas (España), LODYN SL, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Institució Catalana de Recerca i Estudis Avançats (ICREA)B1 Patente con informe sobre el estado de la ténic

Composición para suplemento alimenticio

Composición para suplemento alimenticio. Composición que comprende una combinación extrusionada de semilla de lino, salvado de trigo y harina de girasol. Además la presente invención se refiere al uso de dicha composición como suplemento alimenticio para animales, y la obtención, mediante el uso de dicho suplemento, de leche enriquecida en ácidos -linolénico y ruménico.Peer reviewedConsejo Superior de Investigaciones Científicas (CSIC), Lodyn SL, Institut de Recerca I Tecnologia Agroalimentàries (IRTA), Institució Catalana de Recerca i Estudis Avancats (ICREA)A1 Solicitud de patentes con informe sobre el estado de la técnic

Sistema de videoproyección para prácticas en el Laboratorio de Electrónica

Memoria ID-0018. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome

Producción CientíficaBackground: Proliferation and IL-2 production in response to T-cell receptor ligation are impaired in patients with Wiskott- Aldrich syndrome (WAS). The transcription factors nuclear factor-kB (NF-kB), nuclear factor of activated T cells (NF-AT), and activating protein-1 (AP-1) play a critical role in IL-2 gene expression. Objective: To investigate the mechanisms of impaired IL-2 production after T-cell receptor ligation in T cells deficient in WAS protein (WASP). Methods: T cells from WASP2/2 mice were stimulated with anti-CD3 and anti-CD28. Nuclear NF-kB, NF-AT, and AP-1 DNA-binding activity was examined by electroshift mobility assay. NF-ATp dephosphorylation and nuclear localization were examined by Western blot and indirect immunofluorescence. Phosphorylation of the mitogen-activated protein kinases Erk and Jnk, and of their nuclear substrates Elk-1 and c-Jun, was examined by Western blot. Expression of mRNA for IL-2 and the NF-kB–dependent gene A20 and of the AP-1 components c-fos and c-Jun was examined by quantitative RT-PCR. Results: Nuclear translocation and activity of NF-kB were normal in T cells from WASP2/2 mice. In contrast, NF-ATp dephosphorylation and nuclear localization, nuclear AP-1 binding activity, and expression of c-fos, but not c-Jun, were all impaired. Phosphorylation of Jnk, c-Jun, and Erk were normal. However, nuclear translocation of phosphorylated Erk and phosphorylation of its nuclear substrate Elk1, which activates the c-fos promoter, were impaired. Conclusion: These results suggest that WASP is essential for NF-ATp activation, and for nuclear translocation of p-Erk, Elk1 phosphorylation, and c-fos gene expression in T cells. These defects underlie defective IL-2 expression and T-cell proliferation in WAS

Burnout syndrome and work engagement in nursing staff: a systematic review and meta-analysis

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2023.1125133/full#supplementary-materialBackground: A difficult and demanding work environment, such as that often experienced in healthcare, can provoke fatigue, anxiety, distress, and discomfort. This study considers factors that may influence levels of burnout and work engagement among nurses and seeks to determine the relationship between these conditions.Method: A systematic scoping review was performed, in accordance with the PRISMA Extension for Scoping Reviews, based on data obtained from a search of the PubMed/MEDLINE and Scopus databases carried out in 2022 using the search equation: "work engagement AND nurs* AND burnout." This search identified nine quantitative primary studies suitable for inclusion in our analysis.Results: Work overload, type of shift worked, and/or area of hospital service, among other elements, are all relevant to the development of burnout. This syndrome can be countered by social support and appropriate personal resources and values, which are all positively associated with work engagement. Our analysis revealed a significant correlation between work engagement and the different domains of burnout. The correlation effect size between burnout and work engagement was -0.46 (95% CI -0.58, -0.31), with p < 0.001.Conclusion: Well-targeted interventions in the healthcare work environment can reduce burnout levels, strengthen work engagement, and enhance the quality of healthcare.FEDER/Consejeria de Universidad, Investigacion e Innovacion de la Junta de Andalucia P20-0062

La Informática Industrial en las Ingenierías Industriales

El término Informática Industrial se utiliza para dar cabida a un conjunto muy diverso de disciplinas y tecnologías. El encontrar un criterio unificador que articule los diversos enfoques posibles y que, ayude tanto al docente como al alumno, en el proceso de enseñanza/aprendizaje de manera que se brinde conocimiento perdurable y al mismo tiempo actualizado, es una tarea clave. En esta contribución se discuten estas ideas relativas a la docencia de esta disciplina en las diferentes titulaciones de la Escuela de Ingenierías Industriales de la UVA, manifestando ideas de cómo ese marco conceptual puede adaptarse al contexto de las diferentes especialidades.Departamento de Ingeniería de Sistemas y Automática2018-01-0