Testing the equivalence principle via the shadow of black holes

Funding: H.Z. acknowledges support from the USTC fellowship for international visiting professors and from Shanghai Astronomical Observatory. This work is sup- ported in part by the NSFC (No. 11722327, No. 11653002, No. 11961131007, No. 11725312, No. 11421303), by the CAST (No. 2016QNRC001), by the National Youth Talents Program of China, and by the Fundamental Research Funds for Central Universities. The work of D.A.E. is supported in part by the Foundational Questions Institute.We study the equivalence principle, regarded as the cornerstone of general relativity, by analyzing the deformation observable of black hole shadows. Such deformation can arise from new physics and may be expressed as a phenomenological violation of the equivalence principle. Specifically, we assume that there is an additional background vector field that couples to the photons around the supermassive black hole. This type of coupling yields impact on the way the system depends on initial conditions and affects the black hole shadow at different wavelengths by a different amount, and therefore observations of the shadow in different wavelengths could constrain such couplings. This can be tested by future multiband observations. Adopting a specific form of the vector field, we obtain constraints on model parameters from Event Horizon Telescope observations and measurements of gas/stellar orbits.Publisher PDFPeer reviewe

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial

Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA). Methods: In this multicenter, randomized and parallel treatment trial, 346 patients with active RA (disease activity score (28 joints) [DAS28] (erythrocyte sedimentation rate [ESR]) > 5.1) were enrolled from 9 centers. In phase 1, patients received intensive treatment with methotrexate, leflunomide, and hydroxychloroquine, up to 36 weeks, until remission (DAS28 ≤ 2.6) or a low disease activity (2.6 < DAS28 ≤ 3.2) was achieved. In phase 2, patients achieving remission or low disease activity were followed up with randomization to 1 of 2 step-down protocols: leflunomide plus hydroxychloroquine combination or leflunomide monotherapy. The primary endpoints were good European League Against Rheumatism (EULAR) response (DAS28 (ESR) < 3.2 and a decrease of DAS28 by at least 1.2) during the intensive treatment and the disease state retention rate during step-down maintenance treatment. Predictors of a good EULAR response in the intensive treatment period and disease flare in the maintenance period were sought. Results: A good EULAR response was achieved in 18.7%, 36.9%, and 54.1% of patients at 12, 24, and 36 weeks, respectively. By 36 weeks, 75.4% of patients achieved good and moderate EULAR responses. Compared with those achieving low disease activity and a high health assessment questionnaire (HAQ > 0.5), patients achieving remission (DAS28 ≤ 2.6) and low HAQ (≤ 0.5) had a significantly higher retention rate when tapering the DMARDs treatment (P = 0.046 and P = 0.01, respectively). There was no advantage on tapering to combination rather than monotherapy. Conclusions: Remission was achieved in a proportion of patients with RA receiving prolonged intensive DMARD therapy. Low disease activity at the start of disease taper leads to less subsequent flares. Leflunomide is a good maintenance treatment as single treatment

Research Progress on Effect of Brewing Methods on Brewing Quality of Rice Paste

Instant rice paste is a kind of colloidal solution with certain viscosity and consistency formed by mechanical crushing and boiling of grain. Due to its functional characteristics of instant energy supply, strong flavor and rich nutrition, it can quickly adapt to today’s fast-paced life. Water temperature and water quantity can influce water solubility index and gelatinization degree of rice paste after gelatinization. Pasting viscosity and dissolved lubrication degree of rice paste can be affected by punching particle size and modifier treatment. Suitable bubbling parameters based on pasting properties and solubility of rice paste can effectively improve the instant solubility, stability and taste of rice paste. The effects of four brewing methods (water temperature, water volume, particle size and modifier treatment) on the rheology, texture and sensory quality of cereal paste were reviewed. It is expected to provide some reference for the practical application of rice paste

Mechanisms of increased Trichodesmium fitness under iron and phosphorus co-limitation in the present and future ocean

© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature Communications 7 (2016): 12081, doi:10.1038/ncomms12081.Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium for 1 year under Fe/P co-limitation following 7 years of both low and high CO2 selection. Fe/P co-limited cell lines demonstrated a complex cellular response including increased growth rates, broad proteome restructuring and cell size reductions relative to steady-state growth limited by either Fe or P alone. Fe/P co-limitation increased abundance of a protein containing a conserved domain previously implicated in cell size regulation, suggesting a similar role in Trichodesmium. Increased CO2 further induced nutrient-limited proteome shifts in widespread core metabolisms. Our results thus suggest that N2-fixing microbes may be significantly impacted by interactions between elevated CO2 and nutrient limitation, with broad implications for global biogeochemical cycles in the future ocean.Grant support was provided by U.S. National Science Foundation OCE 1260490 to D.A.H., E.A.W. and F.-X.F., and OCE OA 1220484 and G.B. Moore Foundation 3782 and 3934 to M.A.S

Tau Pathology in Parkinson's Disease

Tau protein—a member of the microtubule-associated protein family—is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feature are called tauopathies. Parkinson's disease (PD) was not initially considered to be a typical tauopathy. However, recent studies have demonstrated increasing evidence of tau pathology in PD. A genome-wide association (GWA) study indicated a potential association between tauopathy and sporadic PD. The aggregation and deposition of tau were also observed in ~50% of PD brains, and it seems to be transported from neuron to neuron. The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism

Quantum key distribution without alternative measurements and rotations

A quantum key distribution protocol based on entanglement swapping is proposed. Through choosing particles by twos from the sequence and performing Bell measurements, two communicators can detect eavesdropping and obtain the secure key. Because the two particles measured together are selected out randomly, we need neither alternative measurements nor rotations of the Bell states to obtain security.Comment: 11 pages, no figures, a modified version of quant-ph/0412014, add a security proof and delete the identification par