43 research outputs found
Cyclic Voltammetric Study of Heterogeneous Electron Transfer Rate Constants of Various Organic Compounds in Ionic liquids: Measurements at Room Temperature
New Icetexane and 20-Norabietane Diterpenes with Trypanocidal Activity from Dracocephalum komarovi
A Green Approach for the Electroorganic Synthesis of New Dihydroxyphenyl-indolin-2-one Derivatives
Inner reorganization during the radicalâbiradical transition in a nor-ÎČ-lapachone derivative possessing two redox centers
Nature of Electrogenerated Intermediates in Nitro-Substituted Nor-ÎČ-lapachones: The Structure of Radical Species during Successive Electron Transfer in Multiredox Centers
Electrochemical,
spectroelectrochemical, and theoretical studies
of the reduction reactions in nor-ÎČ-lapachone derivatives including
a nitro redox center showed that reduction of the compounds involves
the formation of several radical intermediates, including a biradical
dianion resultant from the separate reduction of the quinone and nitro
groups in the molecules. Theoretical descriptions of the corresponding
Fukui functions <i>f</i><sub>αα</sub><sup>+</sup> and <i>f</i><sub>ÎČÎČ</sub><sup>+</sup>(<b>r</b>)
and LUMO densities considering finite differences and frozen core
approximations for describing the changes in electron and spin densities
of the system allowed us to confirm these results. A description of
the potential relationship with the obtained results and biological
activity selectivity indexes suggests that both the formation of stable
biradical dianion species and the stability of the semiquinone intermediates
during further reduction are determining factors in the description
of their biological activity
Synthesis of novel 1,4-naphthoquinone derivatives: antibacterial and antifungal agents
A novel series of substituted 1,4-naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 3a and 9 are the most effective compounds against M. luteum as potent antibacterial and C. tenuis and A. niger as potent antifungal. These two compounds are promising as biologically active compounds