760 research outputs found
Almahata Sitta and Brecciated Ureilites: Insights into the Heterogeneity of Asteroids and Implications for Sample Return
Analysis of samples returned to terrestrial laboratories enables more precise measurements and a wider range of techniques to be utilized than can be achieved with either remote sensing or rover instruments. Furthermore, returning samples to Earth allows them to be stored and re-examined with future technology. Following the success of the Hayabusa mission, returning samples from asteroids should be a high priority for understanding of early solar system evolution, planetary formation and differentiation. Meteorite falls provide us with materials and insight into asteroidal compositions. Almahata Sitta (AS) was the first meteorite fall from a tracked asteroid (2008 TC3) [1] providing a rare opportunity to compare direct geochemical observations with remote sensing data. Although AS is predominantly ureilitic, multiple chondritic fragments have been associated with this fall [2,3]. This is not unique, with chondritic fragments being found in many howardite samples (as described in a companion abstract [4]) and in brecciated ureilites, some of which are known to represent ureilitic regolith [5-7]. The heterogeneity of ureilite samples, which are thought to all originate from a single asteroidal ureilite parent body (UPB) [5], gives us information about both internal and external asteroidal variations. This has implications both for the planning of potential sample return missions and the interpretation of material returned to Earth. This abstract focuses on multiple fragments of two meteorites: Almahata Sitta (AS); and Dar al Gani (DaG) 1047 (a highly brecciated ureilite, likely representative of ureilite asteroidal regolith)
Body Surface Area and Baseline Blood Pressure Predict Subclinical Anthracycline Cardiotoxicity in Women Treated for Early Breast Cancer
Background and Aims: Anthracyclines are highly effective chemotherapeutic agents which may cause long-term cardiac damage (chronic anthracycline cardiotoxicity) and heart failure. The pathogenesis of anthracycline cardiotoxicity remains incompletely understood and individual susceptibility difficult to predict. We sought clinical features which might contribute to improved risk assessment. / Methods: Subjects were women with early breast cancer, free of pre-existing cardiac disease. Left ventricular ejection fraction was measured using cardiovascular magnetic resonance before and >12 months after anthracycline-based chemotherapy (>3 months post-Trastuzumab). Variables associated with subclinical cardiotoxicity (defined as a fall in left ventricular ejection fraction of ≥5%) were identified by logistic regression. / Results: One hundred and sixty-five women (mean age 48.3 years at enrollment) completed the study 21.7 months [IQR 18.0-26.8] after starting chemotherapy. All received anthracyclines (98.8% epirubicin, cumulative dose 400 [300-450] mg/m2); 18% Trastuzumab. Baseline blood pressure was elevated (≥140/90mmHg, mean 147.3/86.1mmHg) in 18 subjects. Thirty-four subjects (20.7%) were identified with subclinical cardiotoxicity, independent predictors of which were the number of anthracycline cycles (odds ratio, OR 1.64 [1.17-2.30] per cycle), blood pressure ≥140/90mmHg (OR 5.36 [1.73-17.61]), body surface area (OR 2.08 [1.36-3.20] per standard deviation (0.16m2) increase), and Trastuzumab therapy (OR 3.35 [1.18-9.51]). The resultant predictive-model had an area under the receiver operating characteristics curve of 0.78 [0.70-0.86]. / Conclusions: We found subclinical cardiotoxicity to be common even within this low risk cohort. Risk of cardiotoxicity was associated with modestly elevated baseline blood pressure – indicating that close attention should be paid to blood pressure in patients considered for anthracycline based chemotherapy. The association with higher body surface area suggests that indexing of anthracycline doses to surface area may not be appropriate for all, and points to the need for additional research in this area
Linear Collider Capabilities for Supersymmetry in Dark Matter Allowed Regions of the mSUGRA Model
Recent comparisons of minimal supergravity (mSUGRA) model predictions with
WMAP measurements of the neutralino relic density point to preferred regions of
model parameter space. We investigate the reach of linear colliders (LC) with
and 1 TeV for SUSY in the framework of the mSUGRA model. We find
that LCs can cover the entire stau co-annihilation region provided \tan\beta
\alt 30. In the hyperbolic branch/focus point (HB/FP) region of parameter
space, specialized cuts are suggested to increase the reach in this important
``dark matter allowed'' area. In the case of the HB/FP region, the reach of a
LC extends well past the reach of the CERN LHC. We examine a case study in the
HB/FP region, and show that the MSSM parameters and can be
sufficiently well-measured to demonstrate that one would indeed be in the HB/FP
region, where the lightest chargino and neutralino have a substantial higgsino
component.Comment: 29 pages, 15 EPS figures; updated version slightly modified to
conform with published versio
Cognitive networks: brains, internet, and civilizations
In this short essay, we discuss some basic features of cognitive activity at
several different space-time scales: from neural networks in the brain to
civilizations. One motivation for such comparative study is its heuristic
value. Attempts to better understand the functioning of "wetware" involved in
cognitive activities of central nervous system by comparing it with a computing
device have a long tradition. We suggest that comparison with Internet might be
more adequate. We briefly touch upon such subjects as encoding, compression,
and Saussurean trichotomy langue/langage/parole in various environments.Comment: 16 page
Doing research with children and young people who do not use speech for communication
Despite emphasis in policy on participation of disabled children, we still know relatively little about how to obtain the views of disabled children with significant communication impairment and their views are often overlooked in planning and service provision. This article describes how the views of children who do not use speech were accessed in research aiming to identify disabled children and young people's priorities regarding outcomes of social care and support services. The main challenge was to develop a method that was reliable, non-threatening, enjoyable and relevant to individual children, as well as enabling children to think beyond their everyday life and express what they aspire to
Lower limit on the neutralino mass in the general MSSM
We discuss constraints on SUSY models with non-unified gaugino masses and R_P
conservation. We derive a lower bound on the neutralino mass combining the
direct limits from LEP, the indirect limits from gmuon, bsgamma, Bsmumu and the
relic density constraint from WMAP. The lightest neutralino (mneutralino=6GeV)
is found in models with a light pseudoscalar with MA<200GeV and a large value
for . Models with heavy pseudoscalars lead to mneutralino>18(29)GeV
for . We show that even a very conservative bound from the
muon anomalous magnetic moment can increase the lower bound on the neutralino
mass in models with mu<0 and/or large values of . We then examine
the potential of the Tevatron and the direct detection experiments to probe the
SUSY models with the lightest neutralinos allowed in the context of light
pseudoscalars with high . We also examine the potential of an e+e-
collider of 500GeV to produce SUSY particles in all models with neutralinos
lighter than the W. In contrast to the mSUGRA models, observation of at least
one sparticle is not always guaranteed.Comment: 37 pages, LateX, 16 figures, paper with higher resolution figures
available at
http://wwwlapp.in2p3.fr/~boudjema/papers/bound-lsp/bound-lsp.htm
Equilibrium configurations of two charged masses in General Relativity
An asymptotically flat static solution of Einstein-Maxwell equations which
describes the field of two non-extreme Reissner - Nordstr\"om sources in
equilibrium is presented. It is expressed in terms of physical parameters of
the sources (their masses, charges and separating distance). Very simple
analytical forms were found for the solution as well as for the equilibrium
condition which guarantees the absence of any struts on the symmetry axis. This
condition shows that the equilibrium is not possible for two black holes or for
two naked singularities. However, in the case when one of the sources is a
black hole and another one is a naked singularity, the equilibrium is possible
at some distance separating the sources. It is interesting that for
appropriately chosen parameters even a Schwarzschild black hole together with a
naked singularity can be "suspended" freely in the superposition of their
fields.Comment: 4 pages; accepted for publication in Phys. Rev.
- …