Multidisciplinary approach for outcropping and subsurface Permian-Cenozoic deepwater carbonates (Central Sicily): outcome for paleogeography of the Southern Tethyan continental margin

An integrated stratigraphic study of the outcropping and buried Permian-Cenozoic deep-water carbonate successions have been performed. These successions form some of the tectonic units, mostly buried beneath the Late Neogene sedimentary cover, in the fold and thrust belt of Central Sicily. Three main successions, pertaining to the well known Lercara, Imerese and Sicanian domains, have been reconstructed on the basis of a detailed facies analysis, seismostratigraphic interpretation, biostratigraphy (mostly based on palynological data) and comparison between outcropping and subsurface deep-water sediments. The main results reveal a continuous sedimentation of the deep-water Southern Tethyan Sicilian succession since the Permian to Cenozoic. In detail: a) the Permian-Middle Triassic terrigenous and carbonate deep-water successions, outcropping or buried in the Cerda, Lercara-Roccapalumba and Sosio Valley regions, are well comparable to each other and represent the common substrate of the Mesozoic-Paleogene Imerese and Sicanian carbonate successions; b) the Mesozoic-Paleogene deep-water carbonates, when compared among them, reveal the occurrence of different sedimentary successions (Imerese and Sicanian); c) the Oligo-Miocene foreland basin terrigenous sediments (Numidian flysch) clearly differ from the coeval foreland hemipelagic to open-shelf carbonates. The paleogeographic reconstruction envisages: a) during the Permian-Triassic, a wide subsident continental rifting area, bordered by a shallow-water domain periodically supplying the basin with calciturbiditic to gravity flows sedimentation (rift stage of the Southern Tethyan margin); b) during the Jurassic-Paleogene, two different deep-water basins developed in a context of a post-rift stage. The different sedimentation reflects the location of the Imerese and Sicanian basins, respectively, along adjacent rimmed shelf and stepped carbonate platform margins; c) the Oligo-Miocene sedimentation reflects the afore-mentioned different location of the two deep-water domains. Flysch deposits suggest that the Imerese was located near an accretionary prism, differently the Sicanian open-shelf carbonates and marls developed on a still undeformed foreland

Food Regeneration, Substitution and Urban Consumption in Bologna

This paper traces the recent transformations that have taken place in the city of Bologna to critically redefine the meaning and scope of the changes related to commerce and consumption, and including the city’s more general practices and promotional rhetoric. It will show how, starting from the increase in tourism and the strategic planning and policies to render the city more attractive, the city has undergone a reconfiguration through important regeneration processes linked to food. It will highlight the limited range of political and economic values which, through new ways of regulating public space and access to consumption, have redefined the socio-spatial fabric of certain areas of the city. The processes described will trace a path for deconstructing the reductively optimistic way in which Bologna is being portrayed, which ends up producing forms of displacement and exclusion

La stampa, l\u2019Europa, l\u2019infographics. Prime riflessioni di studio

La costruzione di un discorso che si occupi di ricostruire l'immagine dell'Europa a ventisette a partire dalla sua fonte infografica e utilizzando come principali testi di analisi quelli riconducibili alle pi\uf9 importanti testate giornalistiche nazionali e al labirinto di siti web fruibili dal portale \u201cEuropa\u201d, comporta necessariamente una riflessione sul rapporto tra immagine geografica e territorio

MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration

Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells. In particular, miR- 128-3p-mediated miRNAs down-regulation contributed to aberrant SNAIL and ZEB1 expression thereby promoting the epithelial-to-mesenchymal transition (EMT) program. Drosha also resulted to be implicated in the control of migratory phenotype as its expression counteracted miR-128-3p functional effects. Our study provides mechanistic insights into the function of miR-128-3p as a key regulator of the malignant phenotype of lung cancer cells. This also enforces the remarkable impact of Drosha and Dicer alteration in cancer, and in particular it highlights a role for Drosha in non-smallcell lung cancer cells migration

MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer : The hOrmone and Diet in the ETiology of breast cancer prospective study

report was to investigate whether many years before the diagnosis of breast cancer miRNA expression is already disregulated. In order to test this hypothesis, we compared miRNAs extracted from leukocytes in healthy women who later developed breast cancer and in women who remain healthy during the whole 15-year follow-up time. Accordantly, we used a case-control study design nested in the hOrmone and Diet in the ETiology of breast cancer (ORDET) prospective cohort study addressing the possibility that miRNAs can serve as both early biomarkers and components of the hormonal etiological pathways leading to breast cancer development in premenopausal women. We compared leukocyte miRNA profiles of 191 incident premenopausal breast cancer cases and profiles of 191 women who remained healthy over a follow-up period of 20 years. The analysis identified 20 differentially expressed miRNAs in women candidate to develop breast cancer versus control women. The upregulated miRNAs, miR-513-a-5p, miR- 513b-5p and miR-513c-5p were among the most significantly deregulated miRNAs. In multivariate analysis, miR-513a-5p upregulation was directly and statistically significant associated with breast cancer risk (OR = 1.69; 95% CI 1.08-2.64; P = 0.0293). In addition, the upregulation of miR-513-a-5p displayed the strongest direct association with serum progesterone and testosterone levels. The experimental data corroborated the inhibitory function of miR-513a-5p on progesterone receptor expression confirming that progesterone receptor is a target of miR-513a-5p. The identification of upregulated miR-513a-5p with its oncogenic potential further validates the use of miRNAs as long-term biomarker of breast cancer risk

Geografia e performance. Riflessioni a partire da una cena con delitto

Reworking the authorial and theatrical experience within the context of a murder mystery game staged at the Società Geografica Italiana during the 2023 European GeoNight, the text reflects on the role of performance as an opportunity to explore and expand the definition of public geography, the latter being understood as the expression and manifestation of what geographers 'can do'

Geografia e performance. Riflessioni a partire da una cena con delitto

Rielaborando l’esperienza autoriale e attoriale nell’ambito di una cena con delitto in- scenata presso la Società Geografica Italiana in occasione della Notte Europea della Geo- grafia del 2023, il testo riflette sul ruolo delle performance come occasione per esplorare ed espandere la definizione di geografia pubblica, intesa come espressione e manifestazione di ciò che geografe e geografi ‘possono fare’.Reworking the authorial and theatrical experience within the context of a murder mystery game staged at the Società Geografica Italiana during the 2023 European GeoNight, the text reflects on the role of performance as an opportunity to explore and expand the definition of public geography, the latter being understood as the expression and manifestation of what geographers ‘can do’

La rigenerazione del Mercato delle Erbe

Il capitolo descrive criticamente il processo di rigenerazione commerciale del Mercato delle Erbe evidenziando le questioni relative alla sostituzione commerciale e all'emersione di nuove conflittualit\ue0 socio-spaziali