State Weakness in Eastern Europe: concept and causes

State weakness has come to be recognized as a key problem for the transformations in a number of Eastern European countries, particularly those East and South of enlargement. This paper addresses the issue firstly by asking how state capacity can be assessed and observed empirically, and secondly, by considering the variables which may explain why some countries have developed weaker states than others. The paper is divided into three broad sections. The first section discusses the issue of how to assess state capacity. As a starting point, I distinguish between the state as a provider of solutions and the state as a source of problems. Both aspects need to be addressed in any evaluation of a state's capacity. Subsequently, the section discusses a number of qualitative and quantitative indicators which can yield useful information on the 'state of the state'. The second section turns to possible explanatory approaches. It considers the potential importance of legacies, of international integration, of the level of development, and of political consolidation. I conclude that the latter appears most directly relevant to the relative level of state capacity, while legacies and the level of development are important background conditions. International integration appears to be driven by higher capability rather than being a factor for stifling state capacity. The third and final section suggests some ways forward from situations of low state capacity. A first path is to promote learning and incremental improvements within the state. A second option is to enhance the capacity of citizens and civil society to demand more and better solutions from the state and to be able to challenge the state when it becomes a source of problems. A third option is to redesign the political systems in such a way as to increase coherence and to clearly attribute responsibility.governance; transition processes; post-Communism

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts

Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by 120 min of reperfusion. The inhibitors were added to the perfusion fluid in various final concentrations from the beginning of the experiments before the coronary artery was blocked. Hemodynamic monitoring and biochemical analysis of perfusion fluid from the coronary outflow were carried out. Myocardial infarct size and the area at risk (transiently non-perfused myocardium) were determined from left ventricular slices after a special staining procedure with Evans blue and 2,3,5-triphenyltetrazolium chloride. The infarcted area (dead myocardium) was 77.9 +/- 2.3% of the area at risk in untreated controls (n=12). The infarct size was significantly reduced in the presence of both calpain inhibitors. The best effect was achieved with 10(-8) m A-705253 (n=8), which reduced (p<0.001) the infarcted area to 49.3 +/- 3.9% of the area at risk, corresponding to an infarct reduction of 61.8%. No statistical difference was observed between the experimental groups in coronary perfusion, left ventricular pressure, and in the release of lactate dehydrogenase and creatine kinase from heart muscle

Ambispora reticulata

A new glomeromycotean fungus,Ambispora reticulata, was found in the Swiss Alps and in the Chilean Andes. Only acauloambisporoid spores were detected so far, 87-131 x 125-150 μm in diameter and having a three-layered, yellow-brown to brown outer wall, a bi-layered, hyaline middle wall and a generally three-layered, hyaline inner wall. The middle wall has a characteristic reticulate outer surface with irregular triagonal to octagonal (usually tetrato hexagonal) pits that are surrounded by ridges. As known for all Ambispora species with acaulo-ambisporoid spore formation, the middle wall is a substantial part of the pedicel which connects the spore with the mycelium. The new species is a frequent member of arbuscular mycorrhizal fungal communities in mountainous and subalpine grasslands of the Swiss Alps at 1000-2100 m above sea level. It occurred less frequent in high alpine grasslands and at altitudes below 1000 m, where the fungus was found in a conservation tillage and a low-input tillage system. It was also detected in evergreen and in deciduous forests in the Andes of Southern Chile at elevations of 550-1600 m

Trauma, Memory and Religion

How can we screen trauma? This question might lead the perception of documentary films about atrocities in the 20th and 21st centuries, like S21 THE KHMER ROUGE KILLING MACHINE (Rithy Panh, CAMB/FR 2003) about Cambodia, THE LOOK OF SILENCE (Joshua Oppenheimer, ID/DK 2014) about Indonesia or DAS RADIKAL BÖSE (Stefan Ruzowitzky, AT 2013) about Nazi-Europe. A concern that may emerge as we watch films on atrocities is whether these artistic representations perhaps guide the public away from what “really happened”. There certainly is a huge gap between, on the one hand, the immediate experience of the event that lies behind the interpretative screening and, on the other hand, watching the director’s material while neither being a part nor ever having been part of the event. Yet often filmic representations are not intended to show what happened; instead they present case studies to be explored in the present. Often the films contain an inherent critique of genocidal violence and present humanistic perspectives on obedience. Mostly, these films underline the humanity of the victims, seeking to give names, faces and biographies so that they are much more than just numbers. What appears on the screen therefore challenges the audience with a moral question: what would you do

Evaluation of a Novel Thiol–Norbornene-Functionalized Gelatin Hydrogel for Bioprinting of Mesenchymal Stem Cells

Introduction: Three-dimensional bioprinting can be considered as an advancement of the classical tissue engineering concept. For bioprinting, cells have to be dispersed in hydrogels. Recently, a novel semi-synthetic thiolene hydrogel system based on norbornene-functionalized gelatin (GelNB) and thiolated gelatin (GelS) was described that resulted in the photoclick hydrogel GelNB/GelS. In this study, we evaluated the printability and biocompatibility of this hydrogel system towards adipose-tissue-derived mesenchymal stem cells (ASCs). Methods: GelNB/GelS was synthesized with three different crosslinking densities (low, medium and high), resulting in different mechanical properties with moduli of elasticity between 206 Pa and 1383 Pa. These hydrogels were tested for their biocompatibility towards ASCs in terms of their viability, proliferation and differentiation. The extrusion-based bioprinting of ASCs in GelNB/GelS-high was performed to manufacture three-dimensional cubic constructs. Results: All three hydrogels supported the viability, proliferation and chondrogenic differentiation of ASCs to a similar extent. The adipogenic differentiation of ASCs was better supported by the softer hydrogel (GelNB/GelS-low), whereas the osteogenic differentiation was more pronounced in the harder hydrogel (GelNB/GelS-high), indicating that the differentiation fate of ASCs can be influenced via the adaption of the mechanical properties of the GelNB/GelS system. After the ex vivo chondrogenic differentiation and subcutaneous implantation of the bioprinted construct into immunocompromised mice, the production of negatively charged sulfated proteoglycans could be observed with only minimal inflammatory signs in the implanted material. Conclusions: Our results indicate that the GelNB/GelS hydrogels are very well suited for the bioprinting of ASCs and may represent attractive hydrogels for subsequent in vivo tissue engineering applications

Diagnostic utility of small fiber analysis in skin biopsies from children with chronic pain

Introduction Small fiber neuropathies (SFN) are associated with a reduction in quality of life. In adults, epidermal nerve fiber density (END) analysis is recommended for the diagnosis of SFN. In children, END assessment is not often performed. We analyzed small nerve fiber innervation to elucidate the potential diagnostic role of skin biopsies in young patients with pain. Methods Epidermal nerve fiber density and sudomotor neurite density (SND) were assessed in skin biopsies from 26 patients aged 7 to 20 years (15 female patients) with unexplained chronic pain. The results were compared with clinical data. Results Epidermal nerve fiber density was abnormal in 50% and borderline in 35% of patients. An underlying medical condition was found in 42% of patients, including metabolic, autoimmune, and genetic disorders. Discussion Reduction of epidermal nerve fibers can be associated with treatable conditions. Therefore, the analysis of END in children with pain may help to uncover a possible cause and guide potential treatment options